| Index | Ligand Name | Structure | PDB code | Compound Potency nM |
| 1 | 2sw | co-crystal structure of MDM2 (17-111) in complex with compound 25 | 4oas | 0.1 |
| 2 | 2tw | Co-crystal structure of MDM2 with Inhibitor Compound 4 | 4oba | 0.4 |
| 3 | 7hc | MDM2 in complex with SAR405838 | 5trf | 0.88 |
| 4 | 2tz | co-crystal structure of MDM2(17-111) in complex with compound 48 | 4occ | 2 |
| 5 | 0r2 | crystal structure of MDM2 (17-111) in complex with compound 23 | 4ere | 4.2 |
| 6 | 35s | co-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID | 4qo4 | 5 |
| 7 | 4th | Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors: Hdm2 (MDM2) complexed with cpd2 | 4zyi | 8 |
| 8 | 2u7 | Co-Crystal Structure of MDM2 with Inhibitor Compound 49 | 4ogv | 9 |
| 9 | 0y7 | Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors | 4hbm | 12 |
| 10 | 6ss | Discovery of New Natural-product-inspired Spiro-oxindole Compounds as Orally Active Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 6g | 5lay | 34 |
| 11 | mi6 | Structure of human MDM2 protein in complex with Mi-63-analog | 3lbl | 36 |
| 12 | diz | Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor | 1t4e | 80 |
| 13 | 1mq | Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid | 4jve | 86 |
| 14 | y30 | Structure of a novel submicromolar MDM2 inhibitor | 4mdn | 600 |
| 15 | 1my | Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid | 4jwr | 610 |
| 16 | 6sk | Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) in complex with compound 6b | 5lav | 819 |
| 17 | 1mn | Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one | 4jv7 | 1000 |
| 18 | yin | crystal structure of MDM2 with chromenotriazolopyrimidine 1 | 3jzk | 1230 |
| 19 | 1mo | Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one | 4jv9 | 1800 |