The Ligandable Human Proteome

Home

Egl nine homolog 1

Oxoglutarate/iron-dependent dioxygenase

IndexLigand NameStructurePDB codeCompound Potency nM
14jrStructure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors4jzr15.8
2a1zHIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Vadadustat5ox629
3qnmHIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and 2-(4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid4bqw33
4un9S-nitrosylated PHD2 (NO exposed) in complex with Fe(II) and UN92y3480
5un9HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)4bqx300
6fntHIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Fe(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]alanine4bqy1100
74hgCellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)2g191400
842zPHD2-R717 with 407874223oui1.26e+004