| Index | Ligand Name | Structure | PDB code | Compound Potency nM |
| 1 | 0qk | Crystal Structure of DOT1L in complex with EPZ004777 | 4eki | 0.1 |
| 2 | 0qj | Crystal Structure of DOT1L in Complex with EPZ003696 | 4ekg | 1.7 |
| 3 | 5ek | Crystal structure of Dot1L in complex with inhibitor CPD3 [N-(1-(2-chlorophenyl)-1H-indol-6-yl)-2-(2-(5-(2-chlorophenyl)-1H-tetrazol-1-yl)acetyl)hydrazinecarboxamide] | 5dry | 20 |
| 4 | 5eg | Crystal structure of Dot1L in complex with inhibitor CPD2 [2-(2-(5-((2-chlorophenoxy)methyl)-1H-tetrazol-1-yl)acetyl)-N-(4-chlorophenyl)hydrazinecarboxamide] | 5drt | 4400 |
| 5 | ep4 | Crystal structure of DOT1L in complex with EPZ000004 | 4ek9 | 3.8e+004 |
| 6 | 5f6 | Crystal structure of Dot1L in complex with inhibitor CPD3 [(2,6-dichlorophenyl)(quinolin-6-yl)methanone] | 5dtq | 1.39e+005 |