The Ligandable Human Proteome

Renin

Index	Ligand Name	Structure	PDB code	Compound Potency nM
1	2y9	Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors	4q1n	0.2
2	rx5	Clinically Useful Alkyl Amine Renin Inhibitors	3q4b	0.47
3	72x	Crystal structure of human renin complexed with a novel inhibitor	3gw5	0.47
4	0iu	CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS	1bil	0.5
5	6vr	Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor	5koq	0.58
6	c41	Crystal Structure of Renin with Inhibitor 10 (Aliskiren)	2v0z	0.6
7	43t	Renin in complex with (S)-1-(3-fluoro-5-(((S)-1-phenylethyl)carbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium	4s1g	0.6
8	hhe	Human renin in complex with compound 5	3vuc	0.9
9	0qb	CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS	1bim	1.2
10	90d	Crystal Structure of Human Renin in Complex with a biphenylpipderidinylcarbinol	5v8v	1.3
11	22x	Optimization of Orally Bioavailable Alkyl Amine Renin Inhibitors	3km4	1.3
12	r32	Human renin in complex with compound 18	3vsx	1.4
13	6vs	Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor	5kos	1.5
14	9g7	Crystal Structure of Human Renin in Complex with a biphenylpipderidinylcarbinol	5vpm	1.6
15	vyf	Human renin in complex with inhibitor 9	3vyf	1.6
16	ssr	Crystal Structure Analysis of Renin-indole-piperazin inhibitor complexes	3oot	2
17	s53	Structure-Based Optimization of Potent 4- and 6-Azaindole-3-Carboxamides as Renin Inhibitors	3sfc	3
18	0n0	Crystal structure of renin in complex with NVP-BGQ311 (compound 12)	4gjd	3
19	c47	Crystal Structure of Renin with Inhibitor 3	2v16	6
20	vye	Human renin in complex with inhibitor 7	3vye	7.7
21	3zj	RENIN IN COMPLEXED WITH N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide INHIBITOR	4ryg	8
22	03d	HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS	1hrn	9
23	3ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring	2g1r	20
24	rpf	crystal structure of renin-pf00257567 complex	2bkt	23
25	c40	Crystal Structure of Renin with Inhibitor 7	2v13	26
26	rx0	Alkyl Amine Renin Inhibitors: Filling S1 from S3	3q3t	37
27	3zn	RENIN IN COMPLEXED WITH (3S,4S)-4-({[4-methoxy-3-(3-methoxypropoxy)benzoyl](propan-2-yl)amino}methyl)pyrrolidin-3-yl benzylcarbamate INHIBITOR	4rz1	40
28	70y	Renin in complex with (4S)-4-isopropyl-4-methyl-6-oxo-1-(3-(2-oxo-4-phenylpyrrolidin-1-yl)benzyl)tetrahydropyrimidin-2(1H)-iminium	4xx4	44
29	70x	Renin in complex with (S)-1-(3-(benzylcarbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium	4xx3	56
30	liy	Crystal Structure of Human Renin Complexed with Inhibitors	2iku	79
31	3zk	RENIN IN COMPLEXED WITH 4-methoxy-3-(3-methoxypropoxy)-N-{[(3S,4S)-4-{[(4-methylphenyl)sulfonyl]amino}pyrrolidin-3-yl]methyl}-N-(propan-2-yl)benzamide INHIBITOR	4ryc	80
32	5ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g1y	90
33	0mj	Crystal structure of renin in complex with NVP-BCH965 (compound 9)	4gjc	90
34	s51	Crystal Structure Analysis of Renin-indole-piperazine inhibitor complexes	3oqf	91
35	0lt	Crystal structure of renin in complex with NVP-BCA079 (compound 12a)	4gj7	170
36	2xf	Crystal structure of renin in complex with compound4	4pyv	200
37	vyd	Human renin in complex with inhibitor 6	3vyd	406
38	s52	Crystal Structure Analysis of Renin-indole-piperazin inhibitor complexes	3oqk	420
39	rx6	Clinically Useful Alkyl Amine Renin Inhibitors	3q5h	560
40	0m3	Crystal structure of renin in complex with NVP-AYL747 (compound 5)	4gja	1200
41	7ig	Crystal Structure of Human Renin Complexed with Inhibitor	2iko	3571
42	7ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g24	4000
43	74v	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sy2	1.1e+004
44	74u	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sxn	1.1e+004
45	74y	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sz9	3.8e+004
46	74z	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sy3	4.3e+004
47	0me	Crystal structure of renin in complex with NVP-BBV031 (compound 6)	4gjb	1e+005
48	0lu	Crystal structure of renin in complex with PKF909-724 (compound 3)	4gj8	5e+005
49	0m2	Crystal structure of renin in complex with GP055321 (compound 4)	4gj9	5e+005