The Ligandable Human Proteome

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Index	Ligand Name	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	PDB Codes
1	pfw	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		3qpp
2	jy7	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		6msc
3	9g6	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5znl
4	4xu	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5c2h
5	2f4	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4muw
6	0t7	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4fcb
7	227	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		2o8h
8	pfh	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		2ovv
9	pf6	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		3hqy
10	pfr	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		3qpo
11	540	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		3sn7
12	546	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		3sni
13	c1l	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		3ui7
14	x4c	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		3ws8
15	lkf	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4bbx
16	0jq	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4ddl
17	0t6	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4fcd
18	15h	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4hf4
19	2f5	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4mvh
20	2w1	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4phw
21	4lp	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5axq
22	6dw	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5b4l
23	4xy	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5c29
24	4y2	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5c2a
25	5ay	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5dh5
26	5m6	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5ede
27	6rc	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5k9r
28	8q7	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5uwf
29	8g3	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5xui
30	5m9	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5edi
31	5mf	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5edh
32	6dt	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		5b4k
33	490	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4xy2
34	15j	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4heu
35	f03	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4ajf
36	4hn	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		4ael
37	pfk	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		3qpn
38	pf9	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		3hr1
39	axc	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		2y0j
40	pfj	PDE10	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233		2ovy
41	ev1	PDE10,PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	2wey, 3iak
42	4qj	PDE1B	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Q01064	PDE1B1 PDES1B	5b25
43	0nk	PDE1B	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Q01064	PDE1B1 PDES1B	4npv
44	0ny	PDE1B	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Q01064	PDE1B1 PDES1B	4npw, 5w6e
45	8hm	PDE1B	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Q01064	PDE1B1 PDES1B	5uoy
46	8hp	PDE1B	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Q01064	PDE1B1 PDES1B	5up0
47	epv	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6c7j
48	eoy	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6c7g
49	eoj	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6c7d
50	dy1	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6blf
51	7ov	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5u00
52	q2t	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		4d08
53	788	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		4d09
54	1l6	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		4jib
55	7om	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5tz3
56	7og	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5tza
57	7oj	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5tzc, 5tzz
58	7op	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5tzh
59	7p4	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5tzw
60	7oy	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5tzx
61	19f	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		4htx, 5u7d
62	7xs	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5u7i
63	7xv	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5u7j
64	7y1	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5u7k
65	7y4	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5u7l
66	9gj	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5vp0
67	9ga	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5vp1
68	87r	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		5xkm
69	czv	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6b96
70	czy	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6b97
71	eog	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6c7e
72	eos	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6c7f
73	ep7	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6c7i
74	fkv	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6cyb
75	fkj	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6cyc
76	fkg	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6cyd
77	c6z	PDE2A	cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408		6ezf
78	ibm	PDE2A,PDE3B,PDE4D,PDE5A,PDE7A,PDE8A,PDE9A	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	1rkp, 1soj, 1zkl, 1zkn, 2hd1, 2yy2, 3dyq, 3dys, 3ecn, 3itu, 3n3z, 3qi4
79	666	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13370		1so2
80	pnx	PDE4A	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	P27815	DPDE2	3tvx
81	0mo	PDE4A,PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	P27815	DPDE2	3i8v, 3k4s
82	zg2	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	3o57
83	19t	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	4myq
84	066	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	3gwt
85	fil	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	1xlz
86	20a	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	3d3p
87	sk4	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	3frg
88	0cp	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	3kkt
89	z72	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	3ly2
90	nvw	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	3w5e
91	qpc	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	3wd9
92	2o5	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	4nw7
93	6qq	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	5k6j
94	hbt	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	3hmv
95	6m5	PDE4B,PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	5laq, 5lbo
96	rol	PDE4B,PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	1oyn, 1q9m, 1ro6, 1tbb, 1xmy, 1xn0, 3g4k
97	pil	PDE4B,PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	1xm4, 1xon
98	rof	PDE4B,PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	1xmu, 1xoq, 3g4l
99	cio	PDE4B,PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	1xlx, 1xom
100	via	PDE4B,PDE5A	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Q07343	DPDE4	1udt, 1xos, 2h42
101	vdn	PDE4B,PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	1uho, 1xot, 3b2r
102	m99	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	2fm5
103	m98	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	2fm0
104	krd	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6njh
105	kr4	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6nji
106	ihm	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	3v9b
107	ffz	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6hwo
108	e8h	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6fw3
109	e6z	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6ftw
110	d62	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6fe7
111	d5z	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6feb
112	d5t	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6fdi
113	aku	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6ink, 6inm
114	ako	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6ind
115	ak0	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6imt
116	ajx	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6imr
117	ajl	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6imo
118	d71	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	3g4i
119	15x	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	3iad
120	j25	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	3sl5
121	3gj	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	4w1o
122	3kq	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	4wcu
123	6pt	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	5k1i
124	6q2	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	5k32
125	7dj	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	5tkb
126	r91	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	5wh5
127	akj	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	5wh6
128	e31	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6boj
129	cv8	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6f6u
130	czk	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6f8r
131	czt	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6f8t
132	czq	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6f8u
133	d0b	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6f8v
134	d0e	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6f8w
135	d08	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6f8x
136	d5n	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6fdc
137	dd5	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	6fdc
138	jn7	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	3sl8
139	jn8	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	3sl6
140	jn4	PDE4D	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Q08499	DPDE3	3sl4
141	9t9	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	6acb
142	9m0	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	5zz2
143	7ca	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	2h44
144	5io	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	4oew
145	5bb	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	4ia0
146	24e	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	4md6
147	cia	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	1udu
148	wan	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	3bjc
149	5fo	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	3shy
150	5co	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	3shz
151	5bo	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	3sie
152	ni0	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	4g2w
153	5ba	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	4i9z
154	5eo	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	4oex
155	ni5	PDE5A	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5	4g2y
156	32v	PDE7A	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	Q13946		4pm0
157	epk	PDE7A	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	Q13946		4y2b
158	tc8	PDE7A	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	Q13946		3g3n
159	9q9	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		6a3n
160	wtc	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		3jsi
161	jar	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		3jsw
162	pdb	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		3k3e, 3qi3
163	bye	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		3k3h
164	7rg	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		4e90
165	0wf	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		4g2j
166	0wl	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		4g2l
167	luo	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		4gh6
168	35o	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		4qge
169	49e	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		4y86
170	49d	PDE9A	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083		4y86, 4y8c