The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	szc	ligand complex structure of soluble epoxide hydrolase	5fp0	91.61	17.
2	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	s74	Human soluble epoxide hydrolase in complex with a three substituted cyclopropane derivative	4x6x	82.59	2.3
3	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	q3b	ligand complex structure of soluble epoxide hydrolase	5ali	89.11	86.
4	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	k78	ligand complex structure of soluble epoxide hydrolase	5ai9	90.66	244.
5	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	g3t	Soluble epoxide hydrolase in complex with 1-(4-((4-(tert-butyl)morpholin-2-yl)methoxy)phenyl)-3-cyclohexylurea	6hgx	86.28	no data
6	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	g3q	Soluble epoxide hydrolase in complex with talinolol	6hgv	86.72	no data
7	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	bxv	Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid.	6aum	91.88	no data
8	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	4ua	ligand complex structure of soluble epoxide hydrolase	5alh	88.21	86.
9	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	ciu	Human soluble Epoxide Hydrolase- N-cyclohexyl-N'-(4-iodophenyl)urea complex	1vj5	91.94	120.
10	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	nc4	Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-butyric acid complex	1zd3	88.96	500000.
11	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	nc6	Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-hexanoic acid complex	1zd4	84.63	253000.
12	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	nc7	Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-heptanoic acid complex	1zd5	82.35	13400.
13	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	s82	Human soluble epoxide hydrolase in complex with a synthetic inhibitor	3ant	88.22	8.5
14	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	33n	Crystal Structure of soluble epoxide Hydrolase	3i1y	90.2	7.
15	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	34n	Crystal Structure of soluble epoxide Hydrolase	3i28	90.71	6.
16	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	24d	Crystal Structure of soluble epoxide Hydrolase	3koo	91.9	15.
17	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	mzl	Soluble Epoxide Hydrolase in complex with pyrazole antagonist	3otq	91.9	41.
18	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	zyi	Crystal structure of hydrolase domain of human soluble epoxide hydrolase complexed with a benzoxazole inhibitor	3pdc	91.7	32.
19	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	s0c	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor	3wk5	94.28	15000.
20	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	s0b	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor	3wk6	93.16	6300.
21	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	s0g	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor	3wka	92.22	29000.
22	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	s0i	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor	3wkb	81.61	61000.
23	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	w9m	Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with C9	4c4x	92.81	no data
24	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	i23	Crystal structure of human soluble epoxide hydrolase complexed with N-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide.	4hai	88.14	7.9
25	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	1lf	Soluble Epoxide Hydrolase complexed with a carboxamide inhibitor	4jnc	85.17	3.
26	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	2ru	Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea	4ocz	89.25	0.66
27	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	2rv	Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea	4od0	92.72	0.91
28	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	s94	Human soluble epoxide hydrolase in complex with a cyclopropyl urea derivative	4x6y	86.93	19.1
29	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	4a0	Structure of soluble epoxide hydrolase in complex with 2-({[2-(adamantan-1-yl)ethyl]amino}methyl)phenol	4y2x	92.2	510.
30	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	kwb	ligand complex structure of soluble epoxide hydrolase	5aia	95.34	6268.
31	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	v2z	ligand complex structure of soluble epoxide hydrolase	5ak5	88.56	86.
32	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	6nf	ligand complex structure of soluble epoxide hydrolase	5aki	92.72	754.
33	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	6n8	ligand complex structure of soluble epoxide hydrolase	5akl	92.21	86.
34	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	fcw	ligand complex structure of soluble epoxide hydrolase	5ald	91.71	1080.
35	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	r4n	ligand complex structure of soluble epoxide hydrolase	5alg	92.24	30.
36	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	7gm	ligand complex structure of soluble epoxide hydrolase	5alm	90.08	294.
37	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	a0j	ligand complex structure of soluble epoxide hydrolase	5alo	85.41	738.
38	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	qyd	ligand complex structure of soluble epoxide hydrolase	5alp	91.52	86.
39	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	5dq	ligand complex structure of soluble epoxide hydrolase	5als	90	19.
40	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	jqn	ligand complex structure of soluble epoxide hydrolase	5alw	93.44	7050.
41	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	i5t	ligand complex structure of soluble epoxide hydrolase	5am1	90.51	3.
42	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	aub	Crystal structure of soluble epoxide hydrolase in complex with t-AUCB	3wke	91.04	1.3
43	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	aub	ligand complex structure of soluble epoxide hydrolase	5am3	89.69	5.
44	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	mvj	ligand complex structure of soluble epoxide hydrolase	5am4	97.48	113.
45	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	6nz	ligand complex structure of soluble epoxide hydrolase	5am5	93.06	1820.
46	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	e3n	Soluble epoxide hydrolase in complex with LK864	6fr2	85.31	no data
47	HYES	Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2	P34913	49g	Structure of soluble epoxide hydrolase in complex with N-[(1-methyl-1H-pyrazol-3-yl)methyl]-2-phenylethanamine	4y2j	90.38	800000.

The Ligandable Human Proteome

Alpha/beta hydrolase fold-1