The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	vgh	Crystal structure of MTH1 in complex with 18-Crown-6	6imz	78.26	no data
2	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	rux	MTH1 in complex with Ruthenium-based inhibitor	3whw	89.19	6.
3	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	mku	Crystal structure of MTH1 in complex with 3-isomangostin	6aa5	81.49	no data
4	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	mks	Crystal structure of MTH1 in complex with alpha-mangostin (cocktail No. 9)	6aa4	77.91	no data
5	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	rx8	Potent and selective inhibitors of MTH1 probe its role in cancer cell survival	5ans	91.14	2056.
6	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	vgh	Crystal structure of NUDT1 (MTH1) with R-crizotinib	4c9w	82.93	781.
7	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	vhs	Crystal structure of NUDT1 (MTH1) with S-crizotinib	4c9x	81.96	48.
8	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	rje	Potent and selective inhibitors of MTH1 probe its role in cancer cell survival	5ant	96.38	440.
9	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	58t	MTH1 in complex with compound 15	5anu	96.22	0.4
10	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	rgj	MTH1 in complex with compound 15	5anv	94	0.5
11	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	9cq	MTH1 in complex with compound 24	5anw	93.52	3.
12	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	2ge	Structure of human MTH1 in complex with TH588	4n1u	97.11	5.
13	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	8xt	BAY-707 in complex with MTH1	5nhy	93.93	2.3
14	8ODP	7,8-dihydro-8-oxoguanine triphosphatase	P36639	MTH1	c9q	Complex between MTH1 and compound 7 (a 7-azaindole-2-amide derivative)	6f1x	95.08	no data
15	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h5d	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NU000443a	5qhh	82.48	no data
16	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h54	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NUOOA000188	5qh2	87.14	no data
17	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h4g	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NUOOA000191	5qh3	89.79	no data
18	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h3v	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NUOOA000224a	5qh5	92.15	no data
19	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h3d	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with PCM-0102951	5qha	81.98	no data
20	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h2y	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NUOOA000154	5qgw	90.7	no data
21	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h2d	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with FMOPL000420a	5qgh	83.71	no data
22	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h1j	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NUOOA000161	5qgz	89.02	no data
23	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h1g	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NUOOA000301a	5qhf	75.63	no data
24	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h1a	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with FMOPL000706a	5qgj	77.44	no data
25	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h17	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NU000442a	5qhg	81.71	no data
26	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h0s	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with FMOPL000679a	5qgk	89.63	no data
27	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h0p	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NUOOA000180	5qh0	82.93	no data
28	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h0m	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NUOOA000259a	5qh6	90.2	no data
29	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		h0d	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with FMOPL000476a	5qgs	56.13	no data
30	NUDT7	Peroxisomal coenzyme A diphosphatase NUDT7	P0C024		b0v	PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with FMOPL000710a	5qgi	76.98	no data

The Ligandable Human Proteome

NUDIX hydrolase domain