Index | Gene Name Primary | Protein Name | Uniprot ID | Gene Name Synonym | Ligand Name | Structure | PDB Code | ligand desolvation | Ligand Structure | Compound Affinity nM |
1 | 5HT1B | 5-hydroxytryptamine receptor 1B | P28222 | HTR1DB | erm | Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target) | 4iar | 89.47 | | no data |
2 | 5HT1B | 5-hydroxytryptamine receptor 1B | P28222 | HTR1DB | 2gm | Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target) | 4iaq | 89.36 | | no data |
3 | 5HT2A | 5-hydroxytryptamine receptor 2A | P28223 | HTR2 | zot | Crystal structure of 5-HT2AR in complex with zotepine | 6a94 | 95.5 | | no data |
4 | 5HT2A | 5-hydroxytryptamine receptor 2A | P28223 | HTR2 | clr | Crystal structure of 5-HT2AR in complex with risperidone | 6a93 | 55.24 | | no data |
5 | 5HT2A | 5-hydroxytryptamine receptor 2A | P28223 | HTR2 | clr | Crystal structure of 5-HT2AR in complex with zotepine | 6a94 | 58.58 | | no data |
6 | 5HT2B | 5-hydroxytryptamine receptor 2B | P41595 | | erm | Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine | 4ib4 | 92.68 | | no data |
7 | 5HT2B | 5-hydroxytryptamine receptor 2B | P41595 | | erm | Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody | 5tud | 92.97 | | no data |
8 | 5HT2B | 5-hydroxytryptamine receptor 2B | P41595 | | erm | Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase. | 4nc3 | 91.63 | | no data |
9 | 5HT2B | 5-hydroxytryptamine receptor 2B | P41595 | | 7ld | Crystal structure of the LSD-bound 5-HT2B receptor | 5tvn | 92.59 | | 0.91 |
10 | 5HT2B | 5-hydroxytryptamine receptor 2B | P41595 | | h8d | Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor | 6dry | 94.2 | | no data |
11 | 5HT2C | 5-hydroxytryptamine receptor 2C | P28335 | HTR1C | erm | Crystal structure of 5-HT2C in complex with ergotamine | 6bqg | 90.98 | | no data |
12 | 5HT2C | 5-hydroxytryptamine receptor 2C | P28335 | HTR1C | e2j | Crystal structure of 5-HT2C in complex with ritanserin | 6bqh | 90.18 | | no data |
13 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | Structure of human A2A adenosine receptor in complex with ZM241385 obtained from SFX experiments under atmospheric pressure | 6jzh | 81.79 | | no data |
14 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | clr | A2A Adenosine receptor room-temperature structure determined by serial millisecond crystallography | 5nlx | 71.91 | | no data |
15 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | t4e | Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 1.86A obtained from in meso soaking experiments (24 hour soak). | 5om4 | 96.38 | | no data |
16 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | t4e | Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 2.1A obtained from in meso soaking experiments (1 hour soak). | 5om1 | 96.13 | | no data |
17 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | t4e | Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 1.9A obtained from bespoke co-crystallisation experiments. | 5olz | 96.22 | | no data |
18 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | adn | Thermostabilised HUMAN A2a Receptor with adenosine bound | 2ydo | 92.74 | | 30.9 |
19 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | 6dy | Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12c at 1.9A resolution | 5iu7 | 75.81 | | 1.1 |
20 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | 6dz | Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12f at 2.0A resolution | 5iu8 | 78.56 | | 18. |
21 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | 6dx | Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12b at 2.2A resolution | 5iua | 77.39 | | 1.5 |
22 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | 6dv | Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12x at 2.1A resolution | 5iub | 75.83 | | 0.35 |
23 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | 9y2 | Structure of the A2A-StaR2-bRIL562-LUAA47070 complex at 2.0A obtained from in meso soaking experiments. | 5olv | 88.76 | | no data |
24 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 2.7 A resolution | 3vg9 | 76.28 | | no data |
25 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | Crystal structure of the chimeric protein of A2aAR-BRIL in complex with ZM241385 at 1.8A resolution | 4eiy | 81.12 | | no data |
26 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | Crystal structure of the chimeric protein of A2aAR-BRIL with bound iodide ions | 5jtb | 81.22 | | no data |
27 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | 1.9A angstrom A2a adenosine receptor structure with MR phasing using XFEL data | 5k2d | 80.34 | | no data |
28 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385. | 3eml | 81.93 | | 1.8 |
29 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | 2.5 angstrom A2a adenosine receptor structure with sulfur SAD phasing using XFEL data | 5k2a | 82 | | no data |
30 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | 1.9 angstrom A2a adenosine receptor structure with sulfur SAD phasing and phase extension using XFEL data | 5k2c | 80.07 | | no data |
31 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | 2.5 angstrom A2a adenosine receptor structure with MR phasing using XFEL data | 5k2b | 81.54 | | no data |
32 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris | 6aqf | 81.85 | | no data |
33 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | A2A Adenosine receptor cryo structure | 5nm2 | 82.79 | | no data |
34 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with ZM241385 at 1.7A resolution | 5iu4 | 83.76 | | 0.53 |
35 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | Structure of the A2A-StaR2-bRIL562-ZM241385 complex at 1.86A obtained from in meso soaking experiments. | 5olg | 81.56 | | no data |
36 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | zma | 2.35-Angstrom In situ Mylar structure of human A2A adenosine receptor at 100 K | 5vra | 80.8 | | no data |
37 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | nec | Thermostabilised HUMAN A2a Receptor with NECA bound | 2ydv | 94.64 | | 13.8 |
38 | AA2AR | Adenosine receptor A2a | P29274 | ADORA2 | 8jn | Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with PSB36 at 2.8A resolution | 5n2r | 92.7 | | no data |
39 | ACM1 | Muscarinic acetylcholine receptor M1 | P11229 | | y01 | Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium | 5cxv | 53.14 | | no data |
40 | ACM1 | Muscarinic acetylcholine receptor M1 | P11229 | | 0hk | Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium | 5cxv | 99.39 | | no data |
41 | ACM2 | Muscarinic acetylcholine receptor M2 | P08172 | | qnb | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB | 5zk3 | 99.58 | | no data |
42 | ACM2 | Muscarinic acetylcholine receptor M2 | P08172 | | 82f | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with AF-DX 384 | 5zkb | 92.69 | | no data |
43 | ACM2 | Muscarinic acetylcholine receptor M2 | P08172 | | 3c0 | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS (Hg-derivative) | 5yc8 | 97.91 | | no data |
44 | ACM2 | Muscarinic acetylcholine receptor M2 | P08172 | | 3c0 | Crystal structure of M2 muscarinic acetylcholine receptor bound with NMS | 5zk8 | 98.22 | | no data |
45 | ACM2 | Muscarinic acetylcholine receptor M2 | P08172 | | 3c0 | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS | 5zkc | 98.04 | | no data |
46 | ACM2 | Muscarinic acetylcholine receptor M2 | P08172 | | qnb | Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist | 3uon | 99.18 | | no data |
47 | ACM3 | Muscarinic acetylcholine receptor M3 | P20309 | | 0hk | M3-mT4L receptor bound to tiotropium | 4u15 | 99.09 | | no data |
48 | ACM4 | Muscarinic acetylcholine receptor M4 | P08173 | | 0hk | Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium | 5dsg | 99.49 | | no data |
49 | ADRB2 | Beta-2 adrenergic receptor | P07550 | ADRB2R B2AR | k5y | Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71 | 6mxt | 93.06 | | no data |
50 | ADRB2 | Beta-2 adrenergic receptor | P07550 | ADRB2R B2AR | 8vs | Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist | 5x7d | 80.85 | | no data |
51 | ADRB2 | Beta-2 adrenergic receptor | P07550 | ADRB2R B2AR | tim | Cholesterol bound form of human beta2 adrenergic receptor. | 3d4s | 95.98 | | no data |
52 | ADRB2 | Beta-2 adrenergic receptor | P07550 | ADRB2R B2AR | jrz | Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551 | 3ny8 | 92.79 | | no data |
53 | ADRB2 | Beta-2 adrenergic receptor | P07550 | ADRB2R B2AR | jsz | Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist | 3ny9 | 92.67 | | no data |
54 | ADRB2 | Beta-2 adrenergic receptor | P07550 | ADRB2R B2AR | p0g | Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody | 4lde | 95.57 | | no data |
55 | ADRB2 | Beta-2 adrenergic receptor | P07550 | ADRB2R B2AR | cau | In meso in situ serial X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K | 5d5a | 90.88 | | no data |
56 | ADRB2 | Beta-2 adrenergic receptor | P07550 | ADRB2R B2AR | cau | High resolution crystal structure of human B2-adrenergic G protein-coupled receptor. | 2rh1 | 90.76 | | no data |
57 | ADRB2 | Beta-2 adrenergic receptor | P07550 | ADRB2R B2AR | cau | Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist | 5x7d | 92.88 | | no data |
58 | AGTR1 | Type-1 angiotensin II receptor | P30556 | AGTR1A AGTR1B AT2R1 AT2R1B | zd7 | XFEL structure of human Angiotensin Receptor | 4yay | 80.69 | | 2.9 |
59 | AGTR1 | Type-1 angiotensin II receptor | P30556 | AGTR1A AGTR1B AT2R1 AT2R1B | olm | Crystal Structure of Human Angiotensin Receptor in Complex with Inverse Agonist Olmesartan at 2.8A resolution. | 4zud | 81.25 | | 6.9 |
60 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | P21730 | C5AR C5R1 | efd | Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist avacopan | 6c1r | 83.82 | | no data |
61 | CCR5 | C-C chemokine receptor type 5 | P51681 | CMKBR5 | mrv | Crystal Structure of the CCR5 Chemokine Receptor | 4mbs | 80.82 | | no data |
62 | CCR5 | C-C chemokine receptor type 5 | P51681 | CMKBR5 | a4x | The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 34 | 6aky | 82.34 | | no data |
63 | CCR5 | C-C chemokine receptor type 5 | P51681 | CMKBR5 | a4r | The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 21 | 6akx | 79.75 | | no data |
64 | CCR7 | C-C chemokine receptor type 7 | P32248 | CMKBR7 EBI1 EVI1 | jlw | Structure of the human CC Chemokine Receptor 7 in complex with the intracellular allosteric antagonist Cmp2105 and the insertion protein Sialidase NanA | 6qzh | 87.35 | | no data |
65 | CCR9 | C-C chemokine receptor type 9 | P51686 | GPR28 | clr | Crystal structure of the human CC chemokine receptor type 9 (CCR9) in complex with vercirnon | 5lwe | 55.18 | | no data |
66 | CCR9 | C-C chemokine receptor type 9 | P51686 | GPR28 | 79k | Crystal structure of the human CC chemokine receptor type 9 (CCR9) in complex with vercirnon | 5lwe | 98.69 | | 0.11 |
67 | CNR1 | Cannabinoid receptor 1 | P21554 | CNR | zdg | Crystal Structure of the Human Cannabinoid Receptor CB1 | 5tgz | 93.68 | | no data |
68 | CNR1 | Cannabinoid receptor 1 | P21554 | CNR | kca | Cannabinoid Receptor 1-G Protein Complex | 6n4b | 94.82 | | no data |
69 | CNR1 | Cannabinoid receptor 1 | P21554 | CNR | clr | Crystal structure of the human CB1 in complex with agonist AM11542 | 5xra | 66.02 | | no data |
70 | CNR1 | Cannabinoid receptor 1 | P21554 | CNR | clr | Crystal structure of the human CB1 in complex with agonist AM841 | 5xr8 | 60.51 | | no data |
71 | CNR1 | Cannabinoid receptor 1 | P21554 | CNR | clr | Cannabinoid Receptor 1-G Protein Complex | 6n4b | 47.72 | | no data |
72 | CNR1 | Cannabinoid receptor 1 | P21554 | CNR | 8d0 | Crystal structure of the human CB1 in complex with agonist AM841 | 5xr8 | 96.72 | | no data |
73 | CNR1 | Cannabinoid receptor 1 | P21554 | CNR | 7dy | High-resolution crystal structure of the human CB1 cannabinoid receptor | 5u09 | 95.94 | | no data |
74 | CNR2 | Cannabinoid receptor 2 | P34972 | CB2A CB2B | 9ju | Crystal structure of human G protein coupled receptor | 5zty | 96.47 | | no data |
75 | CXCR4 | C-X-C chemokine receptor type 4 | P61073 | | itd | The 2.5 A structure of the CXCR4 chemokine receptor in complex with small molecule antagonist IT1t | 3odu | 83.78 | | 7.3 |
76 | DRD3 | D(3) dopamine receptor | P35462 | | etq | Structure of the human dopamine D3 receptor in complex with eticlopride | 3pbl | 95.41 | | no data |
77 | DRD4 | D(4) dopamine receptor | P21917 | | aqd | Structure of the human D4 Dopamine receptor in complex with Nemonapride | 5wiu | 94.76 | | no data |
78 | EDNRB | Endothelin receptor type B | P24530 | ETRB | d2u | Human endothelin receptor type-B in complex with inverse agonist IRL2500 | 6k1q | 89.5 | | no data |
79 | LPAR1 | Lysophosphatidic acid receptor 1 | Q92633 | EDG2 LPA1 | on9 | Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-9910539 | 4z35 | 96.82 | | no data |
80 | LPAR1 | Lysophosphatidic acid receptor 1 | Q92633 | EDG2 LPA1 | on7 | Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO9780307 | 4z34 | 96.17 | | no data |
81 | LPAR1 | Lysophosphatidic acid receptor 1 | Q92633 | EDG2 LPA1 | on3 | Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-3080573 | 4z36 | 93.32 | | no data |
82 | MTR1A | Melatonin receptor type 1A | P48039 | | jey | XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin | 6me3 | 97.5 | | no data |
83 | MTR1A | Melatonin receptor type 1A | P48039 | | jev | XFEL crystal structure of human melatonin receptor MT1 in complex with ramelteon | 6me2 | 96.51 | | no data |
84 | MTR1B | Melatonin receptor type 1B | P49286 | | jey | XFEL crystal structure of human melatonin receptor MT2 in complex with 2-phenylmelatonin | 6me6 | 96.97 | | no data |
85 | NK1R | Substance-P receptor | P25103 | NK1R TAC1R | gbq | Crystal structure of the human NK1 substance P receptor | 6j20 | 90.8 | | no data |
86 | NK1R | Substance-P receptor | P25103 | NK1R TAC1R | gbq | Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Aprepitant | 6hlo | 90.38 | | no data |
87 | NK1R | Substance-P receptor | P25103 | NK1R TAC1R | gaw | Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Netupitant | 6hlp | 80.09 | | no data |
88 | NPY1R | Neuropeptide Y receptor type 1 | P25929 | NPYR NPYY1 | 9af | The Crystal Structure of Human Neuropeptide Y Y1 Receptor with BMS-193885 | 5zbh | 87.07 | | no data |
89 | OPRK | Kappa-type opioid receptor | P41145 | OPRK | jdc | Structure of the human kappa opioid receptor in complex with JDTic | 4djh | 90.43 | | 0.32 |
90 | OPRM | Mu-type opioid receptor | P35372 | MOR1 | clr | Crystal structure of active mu-opioid receptor bound to the agonist BU72 | 5c1m | 66.64 | | no data |
91 | OPRM | Mu-type opioid receptor | P35372 | MOR1 | clr | Crystal structure of the mu-opioid receptor bound to a morphinan antagonist | 4dkl | 53.51 | | no data |
92 | OPRX | Nociceptin receptor | P41146 | OOR ORL1 | dgv | The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with C-35 (PSI Community Target) | 5dhg | 85.75 | | 0.72 |
93 | OX1R | Orexin receptor type 1 | O43613 | | 4ot | Structures of the human OX1 orexin receptor bound to selective and dual antagonists | 4zjc | 87.75 | | 1.1 |
94 | P2RY1 | P2Y purinoceptor 1 | P47900 | | clr | The human P2Y1 receptor in complex with BPTU | 4xnv | 52.23 | | no data |
95 | P2RY1 | P2Y purinoceptor 1 | P47900 | | bur | The human P2Y1 receptor in complex with BPTU | 4xnv | 70.54 | | 161. |
96 | P2Y12 | P2Y purinoceptor 12 | Q9H244 | HORK3 | clr | Crystal structure of P2Y12 receptor in complex with 2MeSADP | 4pxz | 61.84 | | no data |
97 | P2Y12 | P2Y purinoceptor 12 | Q9H244 | HORK3 | clr | Structure of the human P2Y12 receptor in complex with an antithrombotic drug | 4ntj | 41.59 | | no data |
98 | P2Y12 | P2Y purinoceptor 12 | Q9H244 | HORK3 | azj | Structure of the human P2Y12 receptor in complex with an antithrombotic drug | 4ntj | 85.89 | | 43.9 |
99 | PAR1 | Proteinase-activated receptor 1 | P25116 | CF2R PAR1 TR | vpx | Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom | 3vw7 | 96.06 | | 8. |
100 | PAR2 | Proteinase-activated receptor 2 | P55085 | GPR11 PAR2 | 8tz | Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ8838 at 2.8 angstrom resolution | 5ndd | 99.39 | | 344. |
101 | PE2R3 | Prostaglandin E2 receptor EP3 subtype | P43115 | | p2e | Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2 | 6ak3 | 99.52 | | no data |
102 | PE2R3 | Prostaglandin E2 receptor EP3 subtype | P43115 | | j9p | Crystal structure of EP3 receptor bound to misoprostol-FA | 6m9t | 98.38 | | no data |
103 | PTAFR | Platelet-activating factor receptor | P25105 | PAFR | 9er | Crystal structure of the human platelet-activating factor receptor in complex with SR 27417 | 5zkp | 94.61 | | no data |
104 | PTAFR | Platelet-activating factor receptor | P25105 | PAFR | 9eu | Crystal structure of the human platelet-activating factor receptor in complex with ABT-491 | 5zkq | 96.46 | | no data |
105 | TA2R | Thromboxane A2 receptor | P21731 | | clr | Crystal structure of the human thromboxane A2 receptor bound to daltroban | 6iiv | 35.87 | | no data |
106 | TA2R | Thromboxane A2 receptor | P21731 | | clr | Crystal structure of the human thromboxane A2 receptor bound to ramatroban | 6iiu | 42.78 | | no data |
107 | TA2R | Thromboxane A2 receptor | P21731 | | a90 | Crystal structure of the human thromboxane A2 receptor bound to daltroban | 6iiv | 95.03 | | no data |
108 | TA2R | Thromboxane A2 receptor | P21731 | | a8x | Crystal structure of the human thromboxane A2 receptor bound to ramatroban | 6iiu | 98.06 | | no data |