The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	CAH1	Carbonic anhydrase 1	P00915		n19	Crystal structure of human carbonic anhydrase I in complex with the 4-[(3S)-3 benzyl-4-(4-sulfamoylbenzoyl)piperazine -1-carbonyl]benzene-1-sulfonamide inhibitor	6ex1	77.53	no data
2	CAH1	Carbonic anhydrase 1	P00915		fo9	Crystal structure of human carbonic anhydrase I in complex with the inhibitor famotidine	6g3v	79.64	no data
3	CAH1	Carbonic anhydrase 1	P00915		d3b	Crystal structure of human carbonic anhydrase I in complex with the 3-(2,5-dimethylphenyl)-1-(2-hydroxy-5-sulfamoylphenyl)urea inhibitor	6faf	83.94	no data
4	CAH1	Carbonic anhydrase 1	P00915		cjk	Crystal structure of human carbonic anhydrase I in complex with the 1-(2-hydroxy-5-sulfamoylphenyl)-3-[(4-methylphenyl)methyl]urea inhibitor	6f3b	75.6	no data
5	CAH1	Carbonic anhydrase 1	P00915		azm	DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I	1azm	86.11	800.
6	CAH1	Carbonic anhydrase 1	P00915		azm	Crystal structure of 19F probe-labeled hCAI in complex with acetazolamide	3w6h	92.78	no data
7	CAH1	Carbonic anhydrase 1	P00915		bzw	Crystal structure of human carbonic anhydrase I in complex with the 4-(4 acetyl-3-benzylpiperazine-1 carbonyl)benzene-1-sulfonamide inhibitor	6evr	77.74	no data
8	CAH12	Carbonic anhydrase 12	O43570		eoq	Crystal structure of human carbonic anhydrase isozyme XII 2-(benzylamino)-4-chloro-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide	6g7a	80.04	no data
9	CAH12	Carbonic anhydrase 12	O43570		em5	Crystal structure of human carbonic anhydrase isozyme XII with 4-chloro-2-(cyclohexylamino)-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide	6g5l	91.45	no data
10	CAH12	Carbonic anhydrase 12	O43570		e1f	Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide	4kp5	80.7	833.
11	CAH12	Carbonic anhydrase 12	O43570		e1g	Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with 3-[(Pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide	4kp8	78.36	3330.
12	CAH12	Carbonic anhydrase 12	O43570		azm	CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CARBONIC ANHYDRASE XII COMPLEXED WITH ACETAZOLAMIDE	1jd0	82.33	5.7
13	CAH12	Carbonic anhydrase 12	O43570		6z9	Crystal structure of human carbonic anhydrase isozyme XII with 3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide	5llp	85.54	no data
14	CAH12	Carbonic anhydrase 12	O43570		5ef	Crystal structure of human carbonic anhydrase isozyme XII with 3-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hy-droxyethyl)sulfonyl]benzenesulfonamide	5llo	85.62	no data
15	CAH13	Carbonic anhydrase 13	Q8N1Q1		eww	Crystal structure of human carbonic anhydrase isozyme XIII with 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide	4qsj	75.87	no data
16	CAH13	Carbonic anhydrase 13	Q8N1Q1		enn	Crystal structure of human carbonic anhydrase isozyme XIII with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide	6g5u	78.41	no data
17	CAH13	Carbonic anhydrase 13	Q8N1Q1		4md	X-ray structure of human carbonic anhydrase 13 in complex with inhibitor	3da2	77.2	no data
18	CAH13	Carbonic anhydrase 13	Q8N1Q1		e1f	Crystal structure of human carbonic anhydrase isozyme XIII with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide	4knn	76.66	16.7
19	CAH13	Carbonic anhydrase 13	Q8N1Q1		azm	Crystal structure of the human carbonic anhydrase XIII in complex with acetazolamide	3czv	90.98	16.
20	CAH13	Carbonic anhydrase 13	Q8N1Q1		5du	Crystal structure of human carbonic anhydrase isozyme XIII with 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide	5ohh	63.1	no data
21	CAH14	Carbonic anhydrase 14	Q9ULX7		azm	The crystal structure of the human carbonic anhydrase XIV	4lu3	87.55	no data
22	CAH2	Carbonic anhydrase 2	P00918		wzb	Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3,17-O,O-bis-sulfamate	3oik	68.46	680.
23	CAH2	Carbonic anhydrase 2	P00918		wzb	Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.	2x7t	61.76	232.
24	CAH2	Carbonic anhydrase 2	P00918		pof	Crystal structure of human carbonic anhydrase II in complex with STX237	3c7p	68.57	0.1
25	CAH2	Carbonic anhydrase 2	P00918		po1	Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate	2gd8	73.37	39.
26	CAH2	Carbonic anhydrase 2	P00918		mb7	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-tosylureido)pyridine-2-sulfonamide inhibitor	4kv0	70.3	no data
27	CAH2	Carbonic anhydrase 2	P00918		mb6	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-chlorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor	4kuv	70.73	no data
28	CAH2	Carbonic anhydrase 2	P00918		mb2	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-fluorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor	4kuw	70.68	no data
29	CAH2	Carbonic anhydrase 2	P00918		m8v	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects	6oe1	64.23	no data
30	CAH2	Carbonic anhydrase 2	P00918		m8s	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects	6oe0	72.7	no data
31	CAH2	Carbonic anhydrase 2	P00918		js7	Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide	3m3x	67.55	150.
32	CAH2	Carbonic anhydrase 2	P00918		j75	Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide	3mhm	66.33	100.
33	CAH2	Carbonic anhydrase 2	P00918		j74	Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide	3m2n	74.49	no data
34	CAH2	Carbonic anhydrase 2	P00918		j71	Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide	3mhl	71.68	56.
35	CAH2	Carbonic anhydrase 2	P00918		j45	Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]benzenesulfonamide	3m40	70.01	170.
36	CAH2	Carbonic anhydrase 2	P00918		inq	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE	1i91	72.56	1.15
37	CAH2	Carbonic anhydrase 2	P00918		inl	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE	1i8z	71.74	1.27
38	CAH2	Carbonic anhydrase 2	P00918		i7c	The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide	2pow	87.05	63.
39	CAH2	Carbonic anhydrase 2	P00918		i7b	Human Carbonic Anhydrase II complexed with Althiazide	3l14	88.74	no data
40	CAH2	Carbonic anhydrase 2	P00918		i7b	The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide	2pov	88.9	75.
41	CAH2	Carbonic anhydrase 2	P00918		fo9	Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine	6g3q	70.09	no data
42	CAH2	Carbonic anhydrase 2	P00918		fkq	The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide.	6h33	72.47	no data
43	CAH2	Carbonic anhydrase 2	P00918		fkk	The crystal structure of human carbonic anhydrase II in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide.	6h34	75.93	no data
44	CAH2	Carbonic anhydrase 2	P00918		fke	The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.	6h2z	72.02	no data
45	CAH2	Carbonic anhydrase 2	P00918		ff5	Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13	6gxb	68.78	no data
46	CAH2	Carbonic anhydrase 2	P00918		fc4	Human carbonic anhydrase II in complex with ligand	5j8z	84.96	5.
47	CAH2	Carbonic anhydrase 2	P00918		ewz	Crystal structure of human carbonic anhydrase isozyme II with 5-{[(4-tert-buthyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}-2-chlorobenzenesulfonamide	4qsi	75.47	no data
48	CAH2	Carbonic anhydrase 2	P00918		eww	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide	4qsa	73.08	no data
49	CAH2	Carbonic anhydrase 2	P00918		enn	Crystal structure of human carbonic anhydrase isozyme II with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide	6g6t	81.03	no data
50	CAH2	Carbonic anhydrase 2	P00918		e59	Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide	3s8x	69.92	50.
51	CAH2	Carbonic anhydrase 2	P00918		dwh	The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor	3mna	62.99	41.
52	CAH2	Carbonic anhydrase 2	P00918		daw	Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole	3kne	77.53	no data
53	CAH2	Carbonic anhydrase 2	P00918		bzu	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE	1a42	78.36	0.13
54	CAH2	Carbonic anhydrase 2	P00918		bz1	Joint X-ray/neutron structure of human carbonic anhydrase II in complex with brinzolamide	6bbs	76.24	no data
55	CAH2	Carbonic anhydrase 2	P00918		bz1	Human Carbonic Anhydrase II in complex with Brinzolamide	4m2r	77.58	3.2
56	CAH2	Carbonic anhydrase 2	P00918		bz1	Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide	4m2v	77.68	36.
57	CAH2	Carbonic anhydrase 2	P00918		al4	CARBONIC ANHYDRASE II INHIBITOR	1bnq	80.69	0.32
58	CAH2	Carbonic anhydrase 2	P00918		al3	CARBONIC ANHYDRASE II INHIBITOR	1bnu	78.25	0.2
59	CAH2	Carbonic anhydrase 2	P00918		9e2	Carbonic Anhydrase II Inhibitor RA8	5nxv	61.03	no data
60	CAH2	Carbonic anhydrase 2	P00918		75y	Human carboanhydrase F131C_C206S double mutant in complex with 14	5t74	82.55	no data
61	CAH2	Carbonic anhydrase 2	P00918		6ke	Human carbonic anhydrase II in complex with ligand	5j8z	71.93	no data
62	CAH2	Carbonic anhydrase 2	P00918		51j	Three dimensional structure of human carbonic anhydrase II in complex with 2-(But-2-yn-1-ylsulfamoyl)-4-sulfamoylbenzoic acid	5aml	78.26	0.7
63	CAH2	Carbonic anhydrase 2	P00918		45i	Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid	5amd	77.11	2.8
64	CAH2	Carbonic anhydrase 2	P00918		2vq	The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide	4mo8	85.77	10.1
65	CAH2	Carbonic anhydrase 2	P00918		1vq	The crystal structure of the human carbonic anhydrase II in complex with a nitroimidazole sulfamate inhibitor	5o07	86.15	33.8
66	CAH2	Carbonic anhydrase 2	P00918		eg2	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS	1cnx	69.48	43.
67	CAH2	Carbonic anhydrase 2	P00918		fsb	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE	1g45	67.09	2.3
68	CAH2	Carbonic anhydrase 2	P00918		fsb	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE	1g1d	70.79	0.36
69	CAH2	Carbonic anhydrase 2	P00918		bsb	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE	1g4o	65.77	5.6
70	CAH2	Carbonic anhydrase 2	P00918		f2b	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE	1g46	65.59	1.6
71	CAH2	Carbonic anhydrase 2	P00918		f2b	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE	1g52	69.82	0.29
72	CAH2	Carbonic anhydrase 2	P00918		f6b	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE	1g48	66.39	3.9
73	CAH2	Carbonic anhydrase 2	P00918		f6b	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE	1g53	71.56	0.91
74	CAH2	Carbonic anhydrase 2	P00918		ffb	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE	1g54	68.25	1.5
75	CAH2	Carbonic anhydrase 2	P00918		ioa	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE	1i9n	65.92	2.2
76	CAH2	Carbonic anhydrase 2	P00918		ioe	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE	1i9p	72.62	3.9
77	CAH2	Carbonic anhydrase 2	P00918		sbr	Carbonic Anhydrase II Complexed With (R)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide	1if7	66.37	0.03
78	CAH2	Carbonic anhydrase 2	P00918		sbs	Carbonic Anhydrase II Complexed With (S)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide	1if8	61.78	0.23
79	CAH2	Carbonic anhydrase 2	P00918		sab	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE	1okm	74.09	no data
80	CAH2	Carbonic anhydrase 2	P00918		stb	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5-FLUORESCEIN THIOUREA)BUTANE)]	1okn	66.87	no data
81	CAH2	Carbonic anhydrase 2	P00918		fun	carbonic anhydrase II in complex with furosemide as sulfonamide inhibitor	1z9y	84.28	65.
82	CAH2	Carbonic anhydrase 2	P00918		mpx	Human CA II inhibition by novel sulfonamide	4ito	73.05	no data
83	CAH2	Carbonic anhydrase 2	P00918		mpx	carbonic anhydrase II in complex with N-4-Methyl-1-piperazinyl-N'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor	1zh9	68.12	no data
84	CAH2	Carbonic anhydrase 2	P00918		bos	Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide.	2hd6	71.92	16.
85	CAH2	Carbonic anhydrase 2	P00918		3cc	Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor	2qo8	65.62	3.4
86	CAH2	Carbonic anhydrase 2	P00918		ms5	A chimeric microtubule disruptor with efficacy on a taxane resistant cell line	2wd2	74.97	no data
87	CAH2	Carbonic anhydrase 2	P00918		2c7	Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies	3dd8	66.74	14.
88	CAH2	Carbonic anhydrase 2	P00918		3bs	Crystal structure of the complex between Carbonic Anhydrase II and a spin-labeled sulfonamide incorporating TEMPO moiety	3eft	64.52	12.
89	CAH2	Carbonic anhydrase 2	P00918		tru	carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor	1zgf	79.38	no data
90	CAH2	Carbonic anhydrase 2	P00918		jdr	Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]methyl}benzenesulfonamide	3m5e	71.64	43.
91	CAH2	Carbonic anhydrase 2	P00918		arz	Crystal structure of human cabonic anhydrase II in adduct with an adamantyl analogue of acetazolamide in a novel hydrophobic binding pocket	3mhc	72.63	11.
92	CAH2	Carbonic anhydrase 2	P00918		d9h	Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor	3mmf	67.25	37.
93	CAH2	Carbonic anhydrase 2	P00918		e27	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(1H-imidazo[4,5-c]quinolin-2-ylsulfanyl)acetyl]benzenesulfonamide	3myq	79.5	30.
94	CAH2	Carbonic anhydrase 2	P00918		s6i	Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor	3mzc	77.46	226.
95	CAH2	Carbonic anhydrase 2	P00918		p9b	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor	3n0n	67.24	50.
96	CAH2	Carbonic anhydrase 2	P00918		wwv	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor	3n3j	70.7	3.3
97	CAH2	Carbonic anhydrase 2	P00918		wwz	Carbonic Anhydrase IX-mimic IN Complex WITH U-F	5jn3	72.39	no data
98	CAH2	Carbonic anhydrase 2	P00918		wwz	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor	3n4b	75.63	96.
99	CAH2	Carbonic anhydrase 2	P00918		r21	Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide	3nb5	66.73	18.
100	CAH2	Carbonic anhydrase 2	P00918		oy0	Human Carbonic Anhydrase II complexed with 1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL	3oy0	73.76	10.1
101	CAH2	Carbonic anhydrase 2	P00918		oyq	Structure of Human Carbonic Anhydrase II complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE	3oyq	76.19	10.3
102	CAH2	Carbonic anhydrase 2	P00918		oys	Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE	3oys	76.29	9.
103	CAH2	Carbonic anhydrase 2	P00918		pmx	Human carbonic anhydrase II in complex with (+)-Xylariamide A	3p4v	67.53	8000.
104	CAH2	Carbonic anhydrase 2	P00918		rdt	Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide	3po6	62.95	no data
105	CAH2	Carbonic anhydrase 2	P00918		dt9	Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide	3po6	82.07	87.3
106	CAH2	Carbonic anhydrase 2	P00918		5un	Human CAII bound to N-(4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide	3r16	81.08	50.
107	CAH2	Carbonic anhydrase 2	P00918		ryj	Carbonic Anhydrase complexed with 4-sulfamoyl-N-(2,2,2-trifluoroethyl)benzamide	3ryj	76.82	16.
108	CAH2	Carbonic anhydrase 2	P00918		ryv	Carbonic Anhydrase complexed with N-ethyl-4-sulfamoylbenzamide	3ryv	79.38	86.
109	CAH2	Carbonic anhydrase 2	P00918		ryx	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3ryx	74.3	7.3
110	CAH2	Carbonic anhydrase 2	P00918		ryy	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3ryy	78.14	38.
111	CAH2	Carbonic anhydrase 2	P00918		ryz	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3ryz	71.8	2.4
112	CAH2	Carbonic anhydrase 2	P00918		rz0	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3rz0	76.78	28.
113	CAH2	Carbonic anhydrase 2	P00918		rz1	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3rz1	68.27	1.8
114	CAH2	Carbonic anhydrase 2	P00918		rz5	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3rz5	74.4	13.
115	CAH2	Carbonic anhydrase 2	P00918		rz7	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3rz7	67.54	1.1
116	CAH2	Carbonic anhydrase 2	P00918		rz8	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3rz8	72.8	6.7
117	CAH2	Carbonic anhydrase 2	P00918		e2i	Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-butyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide	3sap	68.37	26.
118	CAH2	Carbonic anhydrase 2	P00918		e65	Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide	3sbh	71.25	52.
119	CAH2	Carbonic anhydrase 2	P00918		e90	Crystal structure of human carbonic anhydrase isozyme II with 4-[(2-pyrimidinylsulfanyl)acetyl]benzenesulfonamide	3sbi	76.94	12.
120	CAH2	Carbonic anhydrase 2	P00918		d7a	Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide	3v7x	62.79	2.7
121	CAH2	Carbonic anhydrase 2	P00918		0fz	Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide	3vbd	71.95	8.6
122	CAH2	Carbonic anhydrase 2	P00918		id4	hCA II in complex with novel sulfonamide inhibitors Set D	4dz9	72.47	no data
123	CAH2	Carbonic anhydrase 2	P00918		1ez	Structure of human carbonic anhydrase II in complex with an adamantyl sulfonamide inhibitor	4ilx	71.17	no data
124	CAH2	Carbonic anhydrase 2	P00918		1go	structure of hCAII in complex with an acetazolamide derivative	4iwz	88.65	51.
125	CAH2	Carbonic anhydrase 2	P00918		e1f	Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide	4knj	73.7	11.1
126	CAH2	Carbonic anhydrase 2	P00918		kr5	Crystal structure of human carbonic anhydrase isozyme II with 4-{[3-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-oxopropyl]amino}benzene-1-sulfonamide	4q6e	74.63	667.
127	CAH2	Carbonic anhydrase 2	P00918		azm	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties	3dc3	81.48	4.9
128	CAH2	Carbonic anhydrase 2	P00918		azm	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with acetazolamide	4k0s	83.54	no data
129	CAH2	Carbonic anhydrase 2	P00918		azm	H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE	2h4n	79.37	2.
130	CAH2	Carbonic anhydrase 2	P00918		azm	CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE	1zsb	83.02	2.5e+008
131	CAH2	Carbonic anhydrase 2	P00918		azm	Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding.	4g0c	80.83	12.
132	CAH2	Carbonic anhydrase 2	P00918		azm	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II	3v2m	83.85	no data
133	CAH2	Carbonic anhydrase 2	P00918		azm	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II	3v2j	80.76	no data
134	CAH2	Carbonic anhydrase 2	P00918		azm	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II	1ydd	83.55	86.
135	CAH2	Carbonic anhydrase 2	P00918		azm	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II	1yda	83.32	280.
136	CAH2	Carbonic anhydrase 2	P00918		azm	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II	1ydb	81.28	5.8
137	CAH2	Carbonic anhydrase 2	P00918		df5	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)	4z1e	61.73	5.7
138	CAH2	Carbonic anhydrase 2	P00918		4kc	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)	4z1j	71.77	7.7
139	CAH2	Carbonic anhydrase 2	P00918		4kb	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)	4z1k	69.29	4.7
140	CAH2	Carbonic anhydrase 2	P00918		4kd	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)	4z1n	71.86	5.89
141	CAH2	Carbonic anhydrase 2	P00918		5ef	Crystal structure of human carbonic anhydraseisozyme II with 3-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide	5drs	76.72	1.1
142	CAH2	Carbonic anhydrase 2	P00918		tg4	Human Carbonic Anhydrase II complexed with a two-faced guest	5ekj	65.57	1000.
143	CAH2	Carbonic anhydrase 2	P00918		tg5	Human Carbonic Anhydrase II complexed with a two-faced guest	5ekm	72.15	480.
144	CAH2	Carbonic anhydrase 2	P00918		oe2	An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C	5g03	80.57	no data
145	CAH2	Carbonic anhydrase 2	P00918		8f2	Crystal structure of human carbonic anhydrase II in complex with (R)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide.	5n0d	75.97	3.3
146	CAH2	Carbonic anhydrase 2	P00918		9dh	Carbonic Anhydrase II Inhibitor RA7	5nxp	68.72	no data
147	CAH2	Carbonic anhydrase 2	P00918		9e8	Carbonic Anhydrase II Inhibitor RA11	5ny3	64.32	no data
148	CAH2	Carbonic anhydrase 2	P00918		5du	Crystal structure of human carbonic anhydrase isozyme II with 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide	5doh	87.13	32.
149	CAH2	Carbonic anhydrase 2	P00918		4wa	Human carbonic anhydrase II with an azobenzene inhibitor (1d)	5byi	71.92	30.7
150	CAH2	Carbonic anhydrase 2	P00918		4wa	Human carboanhydrase F131C_C206S double mutant in complex with 2	5t72	77.47	no data
151	CAH2	Carbonic anhydrase 2	P00918		8js	Discovery of new selenoureido analogs of 4-(4-fluorophenylureido) benzenesulfonamides as carbonic anhydrase inhibitors	5wex	76.53	66.3
152	CAH2	Carbonic anhydrase 2	P00918		8js	Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography	5uln	76.25	14.2
153	CAH2	Carbonic anhydrase 2	P00918		42g	Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide	5wlu	52.7	no data
154	CAH2	Carbonic anhydrase 2	P00918		chd	Crystal structure of a highly thermal stabilized variant of Human Carbonic Anhydrase II	4pxx	63.06	no data
155	CAH2	Carbonic anhydrase 2	P00918		chd	Structure of cholate bound to human carbonic anhydrase II	4n16	68.2	no data
156	CAH2	Carbonic anhydrase 2	P00918		cqs	Carbonic anhydrase IX-mimic in complex with nitrogenous base-bearing benezenesulfonamide	6b5a	66.68	no data
157	CAH2	Carbonic anhydrase 2	P00918		cqs	Carbonic anhydrase II in complex with nitrogenous base-bearing benezenesulfonamide	6b59	70.83	no data
158	CAH2	Carbonic anhydrase 2	P00918		g2y	Carbonic anhydrase IX-mimic in complex with sucralose	6cjv	51.38	no data
159	CAH2	Carbonic anhydrase 2	P00918		ets	Joint X-ray/neutron structure of human carbonic anhydrase II in complex with dorzolamide	6bc9	84.08	no data
160	CAH2	Carbonic anhydrase 2	P00918		9eb	Carbonic Anhydrase II Inhibitor RA12	5ny6	83.01	no data
161	CAH2	Carbonic anhydrase 2	P00918		8f3	Crystal structure of human carbonic anhydrase II in complex with (S)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide.	5n0e	68.06	3.6
162	CAH2	Carbonic anhydrase 2	P00918		4k9	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)	4z0q	73.25	6.8
163	CAH2	Carbonic anhydrase 2	P00918		ets	Genetically engineered Carbonic Anhydrase IX in complex with Dorzolamide	4m2w	80.09	52.
164	CAH2	Carbonic anhydrase 2	P00918		ets	Carbonic Anhydrase II in complex with Dorzolamide	4m2u	80.58	9.1
165	CAH2	Carbonic anhydrase 2	P00918		ets	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with dorzolamide	4k13	79.52	no data
166	CAH2	Carbonic anhydrase 2	P00918		e50	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(5-ethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide	3sax	84.85	270.
167	CAH2	Carbonic anhydrase 2	P00918		e49	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide	3s9t	79.55	150.
168	CAH2	Carbonic anhydrase 2	P00918		vz4	Human Carbonic Anhydrase II A65S, N67Q (CA IX mimic) bound with 2-Ethylestrone 3-O-sulfamate	3okv	86.54	590.
169	CAH2	Carbonic anhydrase 2	P00918		vz4	Human Carbonic Anhydrase II in complex with 2-Ethylestrone-3-O-sulfamate	3oku	74.38	440.
170	CAH2	Carbonic anhydrase 2	P00918		vz5	Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate	3oim	73.02	180.
171	CAH2	Carbonic anhydrase 2	P00918		vz5	Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3-O-sulfamate	3oil	72.71	2100.
172	CAH2	Carbonic anhydrase 2	P00918		j43	Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]benzenesulfonamide	3mho	80.13	320.
173	CAH2	Carbonic anhydrase 2	P00918		bfg	Fragment tethered to Carbonic Anhydrase II H64C mutant	3m5t	69.53	no data
174	CAH2	Carbonic anhydrase 2	P00918		te1	Coumarins are a novel class of suicide carbonic anhydrase inhibitors	3f8e	65.13	59.
175	CAH2	Carbonic anhydrase 2	P00918		klt	Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference	3f4x	76.33	no data
176	CAH2	Carbonic anhydrase 2	P00918		bl1	Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications	3bl1	75.68	2520.
177	CAH2	Carbonic anhydrase 2	P00918		ctf	Crystal structure of the human carbonic anhydrase II in complex with STX 641 at 1.85 angstroms resolution	3bet	72.31	1500.
178	CAH2	Carbonic anhydrase 2	P00918		wza	Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.	2x7u	70.79	5340.
179	CAH2	Carbonic anhydrase 2	P00918		wzc	Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.	2x7s	80.51	1660.
180	CAH2	Carbonic anhydrase 2	P00918		cox	Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II ""selective"" inhibitor Celecoxib	2aw1	83.69	43.
181	CAH2	Carbonic anhydrase 2	P00918		inm	CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R)	1i90	75.65	1.28
182	CAH2	Carbonic anhydrase 2	P00918		mts	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS	1cin	80.2	1.88
183	CAH2	Carbonic anhydrase 2	P00918		pts	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS	1cim	81.91	1.52
184	CAH2	Carbonic anhydrase 2	P00918		ets	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS	1cil	79.7	0.37
185	CAH4	Carbonic anhydrase 4	P22748		ag5	Crystal Structure of soluble domain of CA4 in complex with small molecule.	3f7b	82.39	64.
186	CAH4	Carbonic anhydrase 4	P22748		ag4	Crystal Structure of soluble domain of CA4 in complex with small molecule.	3f7u	82.63	246.
187	CAH4	Carbonic anhydrase 4	P22748		azm	Crystal Structure for the complex of human carbonic anhydrase IV and acetazolamide	5jn8	77.25	no data
188	CAH4	Carbonic anhydrase 4	P22748		ets	Crystal Structure of soluble domain of CA4 in complex with Dorzolamide	3fw3	80.48	43.
189	CAH7	Carbonic anhydrase 7	P43166		fkq	The crystal structure of human carbonic anhydrase VII in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide	6h37	68.75	no data
190	CAH7	Carbonic anhydrase 7	P43166		fkk	The crystal structure of human carbonic anhydrase VII in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide.	6h38	69.27	no data
191	CAH7	Carbonic anhydrase 7	P43166		fke	The crystal structure of human carbonic anhydrase VII in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.	6h36	69.96	no data
192	CAH7	Carbonic anhydrase 7	P43166		azm	Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide	3ml5	81.72	3.
193	CAH9	Carbonic anhydrase 9	Q16790	G250 MN	etk	Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide	6g9u	75.58	no data
194	CAH9	Carbonic anhydrase 9	Q16790	G250 MN	er5	Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide	6g98	76.23	no data
195	CAH9	Carbonic anhydrase 9	Q16790	G250 MN	azm	Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX	3iai	84.28	no data

The Ligandable Human Proteome

Alpha carbonic anhydrase domain