The Ligandable Human Proteome

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Serine proteases, trypsin domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1CFABComplement factor BP00751BF BFDjgtComplement factor B protease domain in complex with the reversible inhibitor N-(2-bromo-4-methylnaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine.6qsw96.75no data
2CFABComplement factor BP00751BF BFDjgqComplement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid6rav88.43no data
3CFABComplement factor BP00751BF BFDjgnComplement factor B protease domain in complex with the reversible inhibitor ((2S,4S)-1-((5,7-dimethyl-1H-indol-4-yl)methyl)-4-methoxypiperidin-2-yl)methanol.6qsx94.42no data
4CFADComplement factor DP00746DF PFDj7bComplement factor D in complex with the inhibitor 2-(2-(3'-(aminomethyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid6qmt89.81no data
5CFADComplement factor DP00746DF PFDj6tComplement factor D in complex with the inhibitor (S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid6qmr87.62no data
6CFADComplement factor DP00746DF PFDe85Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol6fug70.01no data
7CFADComplement factor DP00746DF PFDe7hCOMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 56fty78.68no data
8CFADComplement factor DP00746DF PFDe7eCOMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 66ftz69.52no data
9CFADComplement factor DP00746DF PFD8s2Complement factor D in complex with the inhibitor (2S,4S)-4-Amino-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide]5nb678.61500.
10CFADComplement factor DP00746DF PFD5w5COMPLEMENT FACTOR D IN COMPLEX WITH COMPOUND25fbe80.4714000.
11CFADComplement factor DP00746DF PFD5wcCOMPLEMENT FACTOR D IN COMPLEX WITH COMPOUND 55fck82.116.
12CFADComplement factor DP00746DF PFDqjsCOMPLEMENT FACTOR D IN COMPLEX WITH A REVERSIBLE INDOLE CARBOXYLIC ACID BASED INHIBITOR5mt079.4500000.
13CFADComplement factor DP00746DF PFDm7oCOMPLEMENT FACTOR D IN COMPLEX WITH A REVERSIBLE BENZOIC ACID BASED INHIBITOR5mt485.36500000.
14CFADComplement factor DP00746DF PFD8rwComplement factor D in complex with the inhibitor (S)-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide]5nar79.75500.
15CFADComplement factor DP00746DF PFD8rtComplement factor D in complex with the inhibitor (S)-Pyrrolidine-1,2-dicarboxylic acid 1-[(1-methyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide]5nat79.44no data
16CFADComplement factor DP00746DF PFD8rzComplement factor D in complex with the inhibitor (1R,3S,5R)-2-Aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(3-trifluoromethoxy-phenyl)-amide]5naw85.7250.
17CFADComplement factor DP00746DF PFD8nqComplement factor D5nb783.636.
18CFADComplement factor DP00746DF PFD8s5Complement factor D in complex with the inhibitor (2S,4R)-4-Fluoro-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide]5nba80.5250.
19CFADComplement factor DP00746DF PFDe88Complement factor D in complex with the inhibitor (4-((3-(aminomethyl)phenyl)amino)quinazolin-2-yl)-L-valine6fuh80.78no data
20CFADComplement factor DP00746DF PFDe7wComplement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol6fui80.26no data
21CFADComplement factor DP00746DF PFDe82Complement factor D in complex with the inhibitor (S)-3'-(aminomethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-[1,1'-biphenyl]-3-carboxamide6fut83.72no data
22CMA1ChymaseP23946CYH CYMkpkCrystal Structure of the human Chymase with TJK0024kp076.082.24
23CMA1ChymaseP23946CYH CYM8w6Human chymase in complex with 3-(ethoxyimino)-7-oxo-1,4-diazepane derivative5yjp78.94240.
24CMA1ChymaseP23946CYH CYM8w3Human chymase in complex with 7-oxo-3-(phenoxyimino)-1,4-diazepane derivative5yjm80.1421.
25CMA1ChymaseP23946CYH CYM0bbCrystal Structure of Human Chymase with Benzimidazolone Inhibitor3s0n65.75180.
26CMA1ChymaseP23946CYH CYM1p9Crystal Structure of Human Chymase in Complex with Fragment Linked Benzimidazolone Inhibitor: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid4k6977.9140.
27ELNENeutrophil elastaseP08246ELA2wqqNeutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases5abw63.4817.
28ELNENeutrophil elastaseP08246ELA2jjxCrystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor5a0b62.065.
29ELNENeutrophil elastaseP08246ELA2iuyCrystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor5a8x76.296.5
30ELNENeutrophil elastaseP08246ELA2151Crystal structure of human neutrophil elastase complexed with an inhibitor (GW475151)1h1b64.640.16
31ELNENeutrophil elastaseP08246ELA22hyStructure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor3q7774.946.
32ELNENeutrophil elastaseP08246ELA2iulCrystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor5a8z74.7328.
33ELNENeutrophil elastaseP08246ELA2cqhCrystal structure of highly glycosylated human leukocyte elastase in complex with a thiazolidinedione inhibitor6f5m81.36no data
34FA10Coagulation factor XP00742z34CRYSTAL STRUCTURE OF THE INHIBITOR ZK-807834 (CI-1031) COMPLEXED WITH FACTOR XA1fjs71.450.11
35FA10Coagulation factor XP00742xwgFACTOR XA - CATION INHIBITOR COMPLEX2y5f75.492.
36FA10Coagulation factor XP00742xmhHuman coagulation factor Xa in complex with M551241iqj70.05no data
37FA10Coagulation factor XP00742xmgHuman coagulation factor Xa in complex with M551251iqi76.74no data
38FA10Coagulation factor XP00742xmfHuman coagulation factor Xa in complex with M551431iqh76.37no data
39FA10Coagulation factor XP00742xmeHuman coagulation factor Xa in complex with M551591iqg76.75no data
40FA10Coagulation factor XP00742xmaHuman coagulation factor Xa in complex with M555321ioe72.25no data
41FA10Coagulation factor XP00742xldCrystal Structure of 3-chloro-N-[4-chloro-2-[[(5-chloro-2-pyridinyl)amino]carbonyl]-6-methoxyphenyl]-4-[[(4,5-dihydro-2-oxazolyl)methylamino]methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa1mq674.990.007
42FA10Coagulation factor XP00742xlcCrystal Structure of 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa1mq578.261.
43FA10Coagulation factor XP00742xbvFactor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor2xbv81.173.7
44FA10Coagulation factor XP00742t87FACTOR XA INHIBITOR COMPLEX1g2l71.7357.
45FA10Coagulation factor XP00742rr8Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor2xbx79.2715.
46FA10Coagulation factor XP00742rprCRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR1285151ezq76.720.9
47FA10Coagulation factor XP00742rdrCRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR2089441nfx74.183.
48FA10Coagulation factor XP00742oyjFactor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor2xc579.78no data
49FA10Coagulation factor XP00742mbmX-ray crystal structure of human fxa in complex with (S)-N-((2-METHYLBENZOFURAN-5-YLAMINO)(2-OXO-1-(2-OXO-2- (PYRROLIDIN-1-YL)ETHYL)AZEPAN-3- YLAMINO)METHYLENE)NICOTINAMIDE3k9x71.684.
50FA10Coagulation factor XP00742lziAminopyrrolidine Factor Xa inhibitor2vwm74.4393.
51FA10Coagulation factor XP00742lzhAminopyrrolidine Factor Xa inhibitor2vwl81.3995.
52FA10Coagulation factor XP00742lzfAminopyrrolidine Factor Xa inhibitor2vvc80.663.
53FA10Coagulation factor XP00742lgmFactor xa in complex with the inhibitor 3-methyl-1-(3-(5- oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'- (pyrrolidin-1-ylmethyl)biphenyl-4-yl)-5,6-dihydro-1h- pyrazolo[3,4-c]pyridin-7(4h)-one3kqe73.088.1
54FA10Coagulation factor XP00742lglFactor xa in complex with the inhibitor 1-(3-(5-oxo-4,5- dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'-(pyrrolidin-1- ylmethyl)biphenyl-4-yl)-3-(trifluoromethyl)-5,6-dihydro- 1h-pyrazolo[3,4-c]pyridin-7(4h)-one3kqd74.460.4
55FA10Coagulation factor XP00742lg0FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-(4-methoxyphenyl)-6-(4-(1-(pyrrolidin-1-ylmethyl)cyclopropyl)phenyl)-3-(trifluoromethyl)-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one3cs774.50.021
56FA10Coagulation factor XP00742l1dCrystal Structure of FXa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 12w3k77.270.08
57FA10Coagulation factor XP00742l1cCrystal Structure of FXa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 22w3i77.940.1
58FA10Coagulation factor XP00742jnjX-ray Structure of FXa in complex with 7-fluoroindazole2ra074.5115.9
59FA10Coagulation factor XP00742ivkFactor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor2xc479.789.
60FA10Coagulation factor XP00742ik8Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389)1z6e76.660.19
61FA10Coagulation factor XP00742iibCrystal structure of factor Xa in complex with 212bq679.840.07
62FA10Coagulation factor XP00742iiaCrystal structure of factor Xa in complex with compound ""1""2boh80.433.
63FA10Coagulation factor XP00742i1hCrystal structure of factor Xa in complex with 502bmg76.8818.
64FA10Coagulation factor XP00742gsxCRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j9577.894.
65FA10Coagulation factor XP00742gsjCRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j4i72.041.
66FA10Coagulation factor XP00742gsiStructure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs2vh073.743.1
67FA10Coagulation factor XP00742g15CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j9478.11534.
68FA10Coagulation factor XP00742fxiThe discovery of glycine and related amino acid-based factor xa inhibitors2q1j75.050.8
69FA10Coagulation factor XP00742fi1X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide3sw272.294.71
70FA10Coagulation factor XP00742ffgFactor XA in complex with the inhibitor (R)-6-(2'-((3- HYDROXYPYRROLIDIN-1-YL)METHYL)BIPHENYL-4-YL)-1-(3-(5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN- 7(4H)-ONE3ffg71.980.84
71FA10Coagulation factor XP00742ensCrystal structure of human FXA in complex with methyl (2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-3-{[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]amino}acrylate3ens75.948.9
72FA10Coagulation factor XP00742dt8FACTOR XA IN COMPLEX WITH THE INHIBITOR (1S,2R,4S)-N1-[(5-chloroindol-2-yl)carbonyl]-4-(N,N-dimethylcarbamoyl)-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine2ei867.02no data
73FA10Coagulation factor XP00742d91Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine1wu179.3118.
74FA10Coagulation factor XP00742d76Factor Xa in complex with the inhibitor 1-[6-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine1v3x76.3824.
75FA10Coagulation factor XP00742d1qFactor Xa in complex with D102-43803tk576.44no data
76FA10Coagulation factor XP00742d14Factor XA in complex with a cis-1,2-diaminocyclohexane derivative3iit73.739.5
77FA10Coagulation factor XP00742993Crystal structure of human factor XA complexed with 3-Chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide2p3t74.47no data
78FA10Coagulation factor XP00742663Crystal structure of human factor XA complexed with 3-chloro-N-(4-chloro-2-{[(5-chloropyridin-2-yl)amino]carbonyl}-6-methoxyphenyl)-4-[(1-methyl-1H-imidazol-2-yl)methyl]thiophene-2-carboxamide {Pfizer 320663}2p3u78.44no data
79FA10Coagulation factor XP0074263cFactor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor2xby78.69no data
80FA10Coagulation factor XP007425qcFactor Xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one2fzz71.330.03
81FA10Coagulation factor XP007424qcFactor Xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl)benzamide2g0075.710.18
82FA10Coagulation factor XP007424o4Factor Xa complex with GTC0000064zh871.72no data
83FA10Coagulation factor XP007424o1Factor Xa complex with GTC0004014y7670.08no data
84FA10Coagulation factor XP0074248wFactor Xa complex with GTC0003984y7176.57no data
85FA10Coagulation factor XP00742455Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor2xbw8210.
86FA10Coagulation factor XP0074244iFactor Xa complex with GTC0004414y7b71.36no data
87FA10Coagulation factor XP00742237Factor XA inhibitor2pr373.3no data
88FA10Coagulation factor XP00742815CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR2088151f0r74.1922.
89FA10Coagulation factor XP00742pr2Crystal Structure of Human Coagulation Factor XA Complexed with RPR2087071f0s76.418.
90FA10Coagulation factor XP00742dx9COAGULATION FACTOR XA INHIBITOR COMPLEX1fax73.1641.
91FA10Coagulation factor XP00742xmjHuman coagulation factor Xa in complex with M544761iql76.82no data
92FA10Coagulation factor XP00742xmkHuman coagulation factor Xa in complex with M544711iqm74.09no data
93FA10Coagulation factor XP00742fxvCrystal Structure of Human Coagulation Factor XA Complexed with FXV6731ksn79.50.4
94FA10Coagulation factor XP00742rrpCRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR1327471nfu75.2318.
95FA10Coagulation factor XP00742rrrCRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR2096851nfw80.251.1
96FA10Coagulation factor XP00742rtrCRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR2000951nfy79.851.3
97FA10Coagulation factor XP007424ppFACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID1xkb77no data
98FA10Coagulation factor XP007424ppFACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID1xka78.27131.
99FA10Coagulation factor XP00742784Factor Xa - cation2bok80.76280.
100FA10Coagulation factor XP00742iidCrystal structure of factor Xa in complex with 432bq778.3789.
101FA10Coagulation factor XP00742iieCRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND 452bqw79.833.
102FA10Coagulation factor XP00742gskCrystal structure of a Human Factor Xa inhibitor complex2cji78.46.
103FA10Coagulation factor XP00742d01Factor Xa in complex with the inhibitor 2-[[4-[(5-chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide2d1j78.79no data
104FA10Coagulation factor XP00742d92FACTOR XA IN COMPLEX WITH THE INHIBITOR (-)-cis-N1-[(5-Chloroindol-2-yl)carbonyl]-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine2ei674.4241.
105FA10Coagulation factor XP00742d93FACTOR XA IN COMPLEX WITH THE INHIBITOR trans-N1-[(5-Chloroindol-2-yl)carbonyl]-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine2ei778.87no data
106FA10Coagulation factor XP00742gsqCRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j2u78.7347.
107FA10Coagulation factor XP00742gs6CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j3477.8415.
108FA10Coagulation factor XP00742gs5CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j3877.47no data
109FA10Coagulation factor XP00742701Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa2uwo80.092.
110FA10Coagulation factor XP00742895Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa2uwl77.594.
111FA10Coagulation factor XP00742894Factor Xa inhibitor complex2uwp78.06154.
112FA10Coagulation factor XP00742bi7Factor Xa - cation inhibitor complex2jkh76.569.
113FA10Coagulation factor XP00742gg2Factor Xa in Complex with the Inhibitor APIXABAN (BMS-562247) AKA 1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3, 4-C]PYRIDINE-3-CARBOXAMIDE2p1678.830.08
114FA10Coagulation factor XP00742me1Factor xa in complex with the inhibitor 5-chloro-N-(2-(4-(2-oxopyridin-1(2H)-yl)benzamido)ethyl)thiophene-2-carboxamide2p9379.251.5
115FA10Coagulation factor XP00742me4Factor xa in complex with the inhibitor 3-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)benzamido)cyclohexyl)-1H-indole-6-carboxamide2p9475.270.67
116FA10Coagulation factor XP00742me5Factor xa in complex with the inhibitor 5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-YL)benzamido) cyclopentyl)thiophene-2-carboxamide2p9581.510.43
117FA10Coagulation factor XP00742230An Orally Efficacious Factor Xa Inhibitor2phb77.120.32
118FA10Coagulation factor XP00742h22Aminopyrrolidine Factor Xa inhibitor2vvu78.748.
119FA10Coagulation factor XP00742h21Aminopyrrolidine-related triazole Factor Xa inhibitor2vvv79.626.
120FA10Coagulation factor XP00742h25Aminopyrrolidine Factor Xa inhibitor2vwn82.9110.
121FA10Coagulation factor XP00742lzgAminopyrrolidine Factor Xa inhibitor2vwo82.3331.
122FA10Coagulation factor XP00742461Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs2wyg74.842.
123FA10Coagulation factor XP00742898Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs2wyj75.461.
124FA10Coagulation factor XP00742fjdFACTOR XA - CATION INHIBITOR COMPLEX2y5g79.06146.
125FA10Coagulation factor XP00742y5hFACTOR XA - CATION INHIBITOR COMPLEX2y5h76.821620.
126FA10Coagulation factor XP00742yetCrystal structure of human FxA in complex with (S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine3hpt77.946.5
127FA10Coagulation factor XP00742443Discovery of Tetrahydropyrimidin-2(1H)-one derivative TAK-442: A potent, selective and orally active factor Xa inhibitor3kl684.523.5
128FA10Coagulation factor XP00742d90Factor Xa in complex with a phenylenediamine derivative3q3k80.327.4
129FA10Coagulation factor XP00742d46factor Xa in complex with D46-52413tk681.77no data
130FA10Coagulation factor XP00742a7iFactor Xa in complex with a potent 2-amino-ethane sulfonamide inhibitor4a7i83.12.
131FA10Coagulation factor XP0074248uFactor Xa complex with GTC0001014y6d79.33no data
132FA10Coagulation factor XP007424o6Factor Xa complex with GTC0004064y7978.1711.
133FA10Coagulation factor XP00742987Factor Xa complex with GTC0004224y7a77.33no data
134FA10Coagulation factor XP007424o5Factor Xa complex with GTC0001024zha79.75no data
135FA10Coagulation factor XP00742rivFactor Xa in complex with BAY59-79392w2681.620.4
136FA10Coagulation factor XP00742rivDesGla-XaS195A Bound to Aptamer 11F7t and Rivaroxaban5vof81.09no data
137FA11Coagulation factor XIP03951xj8Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design4cra76.1760.
138FA11Coagulation factor XIP03951r9bCreating novel F1 inhibitors through fragment based lead generation and structure aided drug design4crf84.550.5
139FA11Coagulation factor XIP03951nrjFACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl [(5E,8S)-8-[(6R)-6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-2-oxo-1,3,4,7,8,10-hexahydro-2H-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate5qqo86.94no data
140FA11Coagulation factor XIP03951nr7FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl [(5E,8S)-8-[(4S)-4-(3-chlorophenyl)-2-oxopiperidin-1-yl]-2-oxo-1,3,4,7,8,10-hexahydro-2H-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate5qqp75.07no data
141FA11Coagulation factor XIP03951j1jHuman FXIa in complex with small molecule inhibitors.4d7682.96no data
142FA11Coagulation factor XIP03951ixaHuman FXIa in complex with small molecule inhibitors.4d7f80.13no data
143FA11Coagulation factor XIP03951e6uHuman FXIa in complex with small molecule inhibitors.4d7g86.17no data
144FA11Coagulation factor XIP03951bvjFACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl ~{N}-[4-[[(1~{S})-2-[(~{E})-3-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3,4-dihydro-1~{H}-isoquinolin-1-yl]carbonylamino]phenyl]carbamate5qcm77.76110.
145FA11Coagulation factor XIP03951buyFACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-[[(1~{S})-2-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3,4-dihydro-1~{H}-isoquinolin-1-yl]carbonylamino]benzoic acid5qcl77.9211.
146FA11Coagulation factor XIP03951buvFACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-[[(2~{S},3~{R})-1-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3-phenyl-pyrrolidin-2-yl]carbonylamino]benzoic acid5qck76.723.
147FA11Coagulation factor XIP039517p0FACTOR XIA IN COMPLEX WITH THE INHIBITOR N-[(1S)-1-benzyl-2-[2-[5-chloro-2-(tetrazol-1-yl)phenyl]ethylamino]-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carboxamide5e2p84.151.6
148FA11Coagulation factor XIP039517p0Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design4crb84.2127.
149FA11Coagulation factor XIP03951716Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide1zpc77.73254.
150FA11Coagulation factor XIP03951624Factor XI complexed with a pyrimidinone inhibitor1zsl75.73no data
151FA11Coagulation factor XIP039515suFACTOR XIA (C500S [C122S]) IN COMPLEX WITH THE INHIBITOR methyl ~{N}-[4-[2-[(1~{S})-1-[[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-2-phenyl-ethyl]pyridin-4-yl]phenyl]carbamate5exn74.6523.
152FA11Coagulation factor XIP039513y5FACTOR XIA IN COMPLEX WITH THE INHIBITOR 1-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]urea4x6n81.911.5
153FA11Coagulation factor XIP039513y4FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl (4-{4-chloro-2-[(1S)-1-({3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]propanoyl}amino)-2-phenylethyl]-1H-imidazol-5-yl}phenyl)carbamate4x6o80.971.9
154FA11Coagulation factor XIP039513y3FACTOR XIA IN COMPLEX WITH THE INHIBITOR 1-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-3-[2-(aminomethyl)-5-chlorobenzyl]urea4x6m77.725.8
155FA11Coagulation factor XIP039513vmFACTOR XIA IN COMPLEX WITH THE INHIBITOR trans-N-{(1S)-1-[4-(3-amino-2H-indazol-6-yl)pyridin-2-yl]-2-phenylethyl}-4-(aminomethyl)cyclohexanecarboxamide4wxi75.238.4
156FA11Coagulation factor XIP0395139fFactor XIa in complex with the inhibitor (2S)-6-amino-N-{(1S)-1-[4-(3-amino-2H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-2-ethylhexanamide4ty773.070.3
157FA11Coagulation factor XIP0395139dFactor XIa in complex with the inhibitor 4-{2-[(1S)-1-({[trans-4-(aminomethyl)cyclohexyl]carbonyl}amino)-2-phenylethyl]-1H-imidazol-4-yl}benzamide4ty674.5430.
158FA11Coagulation factor XIP039511t6Factor XIa in complex with the inhibitor 5-aminocarbonyl-2-[3-[(2s,4r)-6-carbamimidoyl-4-methyl-4-phenyl-2,3-dihydro-1h-quinolin-2-yl]phenyl]benzoic acid4na871.831.5
159FA11Coagulation factor XIP03951368Factor XI catalytic domain complexed with 2-guanidino-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl nicotinate1zlr73.34no data
160FA11Coagulation factor XIP03951427Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenyl)guanidine1zmn80.66no data
161FA11Coagulation factor XIP039515ssFACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-(aminomethyl)-~{N}-[(1~{S})-1-[4-(3-oxidanyl-1~{H}-indazol-5-yl)pyridin-2-yl]-2-phenyl-ethyl]cyclohexane-1-carboxamide5exl78.143.7
162FA11Coagulation factor XIP039515stFACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl ~{N}-[4-[2-[(1~{S})-1-[[4-(aminomethyl)cyclohexyl]carbonylamino]-2-phenyl-ethyl]pyridin-4-yl]phenyl]carbamate5exm72.516.3
163FA11Coagulation factor XIP03951j4xCreating novel F1 inhibitors through fragment based lead generation and structure aided drug design4crg70.32no data
164FA11Coagulation factor XIP03951421Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 6-Carbamimidoyl-4-(3-hydroxy-2-methyl-benzoylamino)-naphthalene-2-carboxylic acid methyl ester1zsk73.73no data
165FA11Coagulation factor XIP03951709Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with N-(7-Carbamimidoyl-naphthalen-1-yl)-3-hydroxy-2-methyl-benzamide1zsj78.21no data
166FA7Coagulation factor VIIP08709gilcrystal structure of factor VII.stf complexed with pd02971212c4f68.7820.
167FA7Coagulation factor VIIP087099s1Crystal Structure of Factor VIIa in complex with 1-[[3-[4-(5-amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-5-hydroxypyrazol-1-yl]phenyl]methyl]-3-phenylurea5pb374.14no data
168FA7Coagulation factor VIIP08709905Short Factor VIIa with a small molecule inhibitor1ygc75.99no data
169FA7Coagulation factor VIIP0870982jFactor VIIa in complex with the inhibitor 3-{[(2R)-17-ethyl-4-methyl-3,12-dioxo-7-[(propan-2-yl)sulfonyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-2-yl]amino}benzamide5u6j78.3123.
170FA7Coagulation factor VIIP087097zjCrystal Structure of Factor VIIa in complex with N-(2-amino-1H-benzimidazol-5-yl)-2-[3-[(2-amino-2-oxoethyl)-methylsulfonylamino]phenyl]acetamide;2,2,2-trifluoroacetic acid5pau76.91no data
171FA7Coagulation factor VIIP087097zaCrystal Structure of Factor VIIa in complex with 2-[(1-aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)-1-(2-phenylpyrrolidin-1-yl)ethanone5paq74.68no data
172FA7Coagulation factor VIIP087097z1Crystal Structure of Factor VIIa in complex with 2-[(1-aminoisoquinolin-6-yl)amino]-2-(5-ethoxy-2-fluorophenyl)-1-(2-phenylpyrrolidin-1-yl)ethanone5pam76.19no data
173FA7Coagulation factor VIIP087097ypCrystal Structure of Factor VIIa in complex with N-[[4-(aminomethyl)-2-(2-amino-2-oxoethoxy)phenyl]methyl]-2-(4-hydroxyphenyl)-2-methoxyacetamide;hydrochloride5pak74.79no data
174FA7Coagulation factor VIIP087097ymhuman factor VIIa in complex with N-(2-amino-1H-benzimidazol-5-yl)-1-[3-[[(3,5-dimethyl-1,2-oxazol-4-yl)carbamoylamino]methyl]phenyl]-5-hydroxypyrazole-4-carboxamide at 1.73A5pai72.64no data
175FA7Coagulation factor VIIP087097xdCrystal Structure of Factor VIIa in complex with 1-[[3-[2-hydroxy-3-(1H-pyrrolo[3,2-c]pyridin-2-yl)phenyl]phenyl]methyl]-3-phenylurea5pab74.38no data
176FA7Coagulation factor VIIP087097lrCrystal Structure of Factor VIIa in complex with N-(2-amino-1H-benzimidazol-5-yl)-2-[3-[(2-amino-2-oxoethyl)-methylsulfonylamino]-5-chlorophenyl]acetamide;2,2,2-trifluoroacetic acid5paf78.64no data
177FA7Coagulation factor VIIP087097ksFactor VIIa in complex with the inhibitor (5R,11R)-11-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-7-(2,2-difluoroethoxy)-5,13-dimethyl-2,13-diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione5tqg78.850.24
178FA7Coagulation factor VIIP087097krFactor VIIa in complex with the inhibitor (11R)-11-[(1-aminoisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-13-methyl-2,13-diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione5tqf80.145.
179FA7Coagulation factor VIIP087097kqFactor VIIa in complex with the inhibitor (5R)-5-[(1-aminoisoquinolin-6-yl)amino]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15-diazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9,16,18-hexaene-4,14-dione5tqe80.2190.
180FA7Coagulation factor VIIP0870970dFactor VIIa in complex with the inhibitor 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,20-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6,8,10(21),16,19-hexaen-7-yl] cyclobutane-1-carboxylic acid5l2y76.520.14
181FA7Coagulation factor VIIP0870970aFactor VIIa in complex with the inhibitor (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-[1-(1H-tetrazol-5-yl)cyclopropyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione5l3075.370.72
182FA7Coagulation factor VIIP0870967oFactor VIIA in complex with the inhibitor (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione5i4680.18no data
183FA7Coagulation factor VIIP087094t0FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-{(2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl)phenyl}acetamide4zxx77.848.
184FA7Coagulation factor VIIP087094k1Factor VIIa in complex with the inhibitor 2-(2-{(R)-[(4-carbamimidoylphenyl)amino][5-ethoxy-2-fluoro-3-(propan-2-yloxy)phenyl]methyl}-1H-imidazol-4-yl)benzamide4yt776.851.7
185FA7Coagulation factor VIIP08709413Factor7 - 413 complex1w7x73.064.
186FA7Coagulation factor VIIP08709413Factor7 - 413 complex1w8b65.82no data
187FA7Coagulation factor VIIP087092kfFactor viia in complex with the inhibitor (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-[2-(propan-2-ylsulfonyl)benzyl]ethanamide4nga80.4217.
188FA7Coagulation factor VIIP087092keFactor viia in complex with the inhibitor (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n-(3-sulfamoylbenzyl)ethanamide4ng977.2575.
189FA7Coagulation factor VIIP0870924xCrystal structure analysis of human Factor VIIa , Souluble tissue factor complexed with BCX-36072ec967.74no data
190FA7Coagulation factor VIIP087091t7Factor VIIa in complex with the inhibitor 3'-amino-5'-[(2s,4r)-6-carbamimidoyl-4-phenyl-1,2,3,4-tetrahydroquinolin-2-yl]biphenyl-2-carboxylic acid4na970.8341.
191FA7Coagulation factor VIIP087091okStructure of factor VIIA in complex with the inhibitor (2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-[3-ETHOXY-4-(PROPAN-2-YLOXY)PHENYL]-N-(PHENYLSULFONYL)ETHANAMIDE4jyu76.0710.
192FA7Coagulation factor VIIP087091ojStructure of factor VIIA in complex with the inhibitor (2R)-2-[3-ETHOXY-4-(PROPAN-2-YLOXY)PHENYL]-2-(ISOQUINOLIN-6-YLAMINO)-N-[(3-SULFAMOYLPHENYL)SULFONYL]ETHANAMIDE4jyv74.1617.
193FA7Coagulation factor VIIP0870903rCrystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid2aei71.9886.
194FA7Coagulation factor VIIP08709cr9Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)1o5d76.46no data
195FA7Coagulation factor VIIP08709380tf7a_4380 complex1w2k77.89350.
196FA7Coagulation factor VIIP08709346Orally available Factor7a inhibitor2bz673.9781.
197FA7Coagulation factor VIIP087097nhNovel 5-Azaindole Factor VIIa Inhibitors2flr80.61800.
198FA7Coagulation factor VIIP087091ggStructure of FACTOR VIIA in complex with the inhibitor (6S)-N-(4-CARBAMIMIDOYLBENZYL)-1-CHLORO-3-(CYCLOBUTYLAMINO)-8,8-DIETHYL-4-OXO-4,6,7,8-TETRAHYDROPYRROLO[1,2-A]PYRAZINE-6-CARBOXAMIDE4isi75.817.3
199FA7Coagulation factor VIIP087094jyFactor VIIa in complex with the inhibitor 4-{[(R)-[5-ethoxy-2-fluoro-3-(propan-2-yloxy)phenyl](4-phenyl-1H-imidazol-2-yl)methyl]amino}benzenecarboximidamide4yt676.5511.
200FA7Coagulation factor VIIP087094t1FACTOR VIIA IN COMPLEX WITH THE INHIBITOR (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione4zxy76.47400.
201FA7Coagulation factor VIIP087097y7human factor VIIa in complex with 5-hydroxy-N-(4-oxo-3H-quinazolin-6-yl)-1-[3-[(phenylcarbamoylamino)methyl]phenyl]pyrazole-4-carboxamide at 1.50A5pac73.71no data
202FA7Coagulation factor VIIP087097yaCrystal Structure of Factor VIIa in complex with (2S)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]propanamide5pae69.88no data
203FA7Coagulation factor VIIP087097yjCrystal Structure of Factor VIIa in complex with (2R)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-methylbutanamide;hydrobromide5pag65.34no data
204FA7Coagulation factor VIIP087097xjCrystal Structure of Factor VIIa in complex with 1-(1-aminoisoquinolin-6-yl)-3-benzylurea5paj82.73no data
205FA7Coagulation factor VIIP087097z4Crystal Structure of Factor VIIa in complex with 5-hydroxy-N-(3-oxo-1,2-dihydroisoindol-5-yl)-1-[3-[(phenylcarbamoylamino)methyl]phenyl]pyrazole-4-carboxamide5pan73.94no data
206FA7Coagulation factor VIIP087097z7Crystal Structure of Factor VIIa in complex with (2S)-2,3-dihydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]propanamide;hydrobromide5pao72.22no data
207FA7Coagulation factor VIIP087097zdCrystal Structure of Factor VIIa in complex with (2S)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylpropanamide5pas79.67no data
208FA7Coagulation factor VIIP087097zgCrystal Structure of Factor VIIa in complex with N-(2-amino-1H-benzimidazol-5-yl)-2-(3-chlorophenyl)acetamide5pat82.09no data
209FA7Coagulation factor VIIP087097zmCrystal Structure of Factor VIIa in complex with N-(6-aminopyridin-3-yl)-5-hydroxy-1-phenylpyrazole-4-carboxamide5pav87.22no data
210FA7Coagulation factor VIIP087097zpCrystal Structure of Factor VIIa in complex with 1-(2,6-difluorophenyl)-3-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]urea5pax70.36no data
211FA7Coagulation factor VIIP087097zyCrystal Structure of Factor VIIa in complex with 1-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea5pay72.07no data
212FA7Coagulation factor VIIP087097lxCrystal Structure of Factor VIIa in complex with 2-(4-ethoxy-3-methoxyphenyl)-2-(isoquinolin-6-ylamino)acetic acid5pb079.32no data
213FA7Coagulation factor VIIP087099rshuman factor VIIa in complex with 1-[[3-[5-hydroxy-3-methyl-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea at 2.43A5pb472.42no data
214FA7Coagulation factor VIIP087099ryhuman factor VIIa in complex with 1-[[3-[5-hydroxy-4-(7H-pyrrolo[2,3-d]pyrimidin-6-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea at 1.84A5pb571.34no data
215FA7Coagulation factor VIIP087099rvCrystal Structure of Factor VIIa in complex with N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]pentanamide5pb668.35no data
216FA9Coagulation factor IXP007405nyDevelopment of a novel tricyclic class of potent and selective FIXa inhibitors5egm73.522.4
217FA9Coagulation factor IXP007404m1Development of a novel class of potent and selective FIXa inhibitors4zae753.6
218FA9Coagulation factor IXP00740izxSelective Benzothiophine Inhibitors of Factor IXa3lc579.09270.
219FA9Coagulation factor IXP007404lnRapid development of two Factor IXa inhibitors from Hit to Lead4z0k75.92462.
220FA9Coagulation factor IXP007407gqDiscovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors5tnt73.984.9
221FA9Coagulation factor IXP007404k6Rapid development of two Factor IXa inhibitors from Hit to Lead4yzu75.029000.
222HEPSSerine protease hepsinP05981TMPRSS1cr9Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)1o5f72.4850.
223HEPSSerine protease hepsinP05981TMPRSS150kCrystal Structure of Serine protease Hepsin in complex with Inhibitor5ce178.49no data
224KLK5Kallikrein-5Q9Y337SCTEj08Crystal Structure of Human Kallikrein 5 in complex with GSK1446qfe92.71no data
225KLK6Kallikrein-6Q92876PRSS18 PRSS9rh5Crystal Structure of Human Kallikrein 6 (N217D/I218Y/K224R) in complex with GSK3496783A6skb89.55no data
226KLK6Kallikrein-6Q92876PRSS18 PRSS9lh8Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK3448330A6skc80.57no data
227KLK6Kallikrein-6Q92876PRSS18 PRSS9lh5Crystal Structure of Human Kallikrein 6 (N217D/I218Y/K224R) in complex with GSK3496783A6skb94.33no data
228KLK6Kallikrein-6Q92876PRSS18 PRSS9lh2Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK3397892A6skd82.89no data
229KLK6Kallikrein-6Q92876PRSS18 PRSS9j3bCrystal Structure of Human Kallikrein 6 in complex with GSK3239861A6qh989.98no data
230KLK6Kallikrein-6Q92876PRSS18 PRSS9j2wCrystal Structure of Human Kallikrein 6 in complex with GSK578724A6qhb80.29no data
231KLK6Kallikrein-6Q92876PRSS18 PRSS9j2qCrystal Structure of Human Kallikrein 6 in complex with GSK3205388B6qha81.03no data
232KLK6Kallikrein-6Q92876PRSS18 PRSS9j2nCrystal Structure of Human Kallikrein 6 in complex with GSK3239861A6qh990.47no data
233KLK6Kallikrein-6Q92876PRSS18 PRSS9j08Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK1446qfg72.55no data
234KLK6Kallikrein-6Q92876PRSS18 PRSS9j08Crystal Structure of Human Kallikrein 6 (N217D/I218Y/K224R) in complex with GSK144.6qfh72.64no data
235KLK6Kallikrein-6Q92876PRSS18 PRSS9j08Crystal Structure of Human Kallikrein 6 in complex with GSK1446qff73.95no data
236KLK6Kallikrein-6Q92876PRSS18 PRSS9135Crystal Structure of Human Kallikrein 6 in complex with GSK358180B6qhc77.72no data
237KLK6Kallikrein-6Q92876PRSS18 PRSS90hlVirtual Screening and X-Ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group3vfe72.41no data
238KLK6Kallikrein-6Q92876PRSS18 PRSS90hmHuman Kallikrein 6 Inhibitors with a para-Amidobenzylanmine P1 Group Carry a High Binding Efficiency4d8n76.231800.
239KLK7Kallikrein-7P49862PRSS6 SCCE8vxHuman kallikrein 7 in complex with 1,4-diazepane-7-one 1-acetamide derivative5yjk69.3820.
240KLK7Kallikrein-7P49862PRSS6 SCCE8r3Human kallikrein 7 in complex with 1,3,6-trisubstituted 1,4-diazepane-7-one5y9l74.411900.
241KLK7Kallikrein-7P49862PRSS6 SCCE5vtKALLIKREIN-7 IN COMPLEX WITH COMPOUND15fah75.51700.
242KLKB1Plasma kallikreinP03952KLK3gbtStructure of human plasma kallikrein5tjx83.39153.
243KLKB1Plasma kallikreinP03952KLK37sdFull length human plasma kallikrein with inhibitor6o1g81.78no data
244KLKB1Plasma kallikreinP03952KLK37sdStructure of human plasma kallikrein protease domain with inhibitor6o1s85.36no data
245ST14Suppressor of tumorigenicity 14 proteinQ9Y5Y6PRSS14 SNC19 TADG15ntxCrystal structure of matriptase in complex with inhibitor4o9763.213.
246ST14Suppressor of tumorigenicity 14 proteinQ9Y5Y6PRSS14 SNC19 TADG15nt4Crystal structure of matriptase in complex with inhibitor4o9v68.0110.
247ST14Suppressor of tumorigenicity 14 proteinQ9Y5Y6PRSS14 SNC19 TADG15n4cCrystal Structure of Matriptase in complex with Inhibitor"".4jzi65.6740.
248ST14Suppressor of tumorigenicity 14 proteinQ9Y5Y6PRSS14 SNC19 TADG15n4aCrystal Structure of Matriptase in complex with Inhibitor4jyt64.3440.
249ST14Suppressor of tumorigenicity 14 proteinQ9Y5Y6PRSS14 SNC19 TADG15f4dCrystal Structure of Matriptase in complex with Inhibitor4jz174.84200.
250ST14Suppressor of tumorigenicity 14 proteinQ9Y5Y6PRSS14 SNC19 TADG15730Crystal Structure of Matriptase with Inhibitor CJ-7302gv654.7746.
251ST14Suppressor of tumorigenicity 14 proteinQ9Y5Y6PRSS14 SNC19 TADG153kmCRYSTAL STRUCTURE of MATRIPTASE in COMPLEX WITH INHIBITOR4r0i65.6300.
252THRBProthrombinP00734unbthrombin in complex with inhibitor2bdy78.0717.
253THRBProthrombinP00734uetThrombin in complex with (2R)-2-(benzylsulfonylamino)-N-(2-((4- carbamimidoylphenyl)methylamino)-2-oxo-propyl)-3-phenyl-propanamide5afz78.77no data
254THRBProthrombinP00734tifHuman Thrombin In Complex With MI3533uwj84.27no data
255THRBProthrombinP00734t87THROMBIN INHIBITOR COMPLEX1g3067.9140.
256THRBProthrombinP00734t76thrombin in complex with selective macrocyclic inhibitor1nt180.411.3
257THRBProthrombinP00734t42HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG1ai871.57no data
258THRBProthrombinP00734t15Crystal structure of thrombin in complex with inhibitor 153c1k75.090.36
259THRBProthrombinP00734s04Human Thrombin in complex with MI0043rmo78.42no data
260THRBProthrombinP00734s00Human Thrombin in complex with MI0033rm282.72no data
261THRBProthrombinP00734ra8X-ray crystal structure of thrombin inhibited by synthetic cyanopeptide analogue RA-10081ypl75.31no data
262THRBProthrombinP00734nliDiscovery and Clinical Evaluation of RWJ-671818, a Thrombin Inhibitor with an Oxyguanidine P1 Motif3ldx81.22no data
263THRBProthrombinP00734na9Orally Active Thrombin Inhibitors in Complex with Thrombin Inh122a2x79.7520.2
264THRBProthrombinP00734n12orally active thrombin inhibitors in complex with thrombin and an exosite decapeptide2ank78.5447.3
265THRBProthrombinP00734mvfThrombin in complex with inhibitor4bao85.084.29
266THRBProthrombinP00734miuAlpha-thrombin complex with sulfated hirudin (residues 54-65) and L- Arginine template inhibitor CS1071w7g82.978000.
267THRBProthrombinP00734mitCRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS1dwc79.6739.
268THRBProthrombinP00734midCRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS1dwd79.396.6
269THRBProthrombinP00734melHUMAN THROMBIN-INHIBITOR COMPLEX1k2282.294.
270THRBProthrombinP00734melThrombin in complex with inhibitor4bah83.122.01
271THRBProthrombinP00734m6sThrombin in complex with inhibitor4ban85.052.43
272THRBProthrombinP00734m67Thrombin in complex with inhibitor4bak85.021.22
273THRBProthrombinP00734m4zThrombin in complex with inhibitor4baq84.660.98
274THRBProthrombinP00734m41Human Thrombin in complex with MI3413rmn77.05no data
275THRBProthrombinP00734m34Human Thrombin In Complex With MI3403t5f80.48no data
276THRBProthrombinP00734l86thrombin in complex with selective macrocyclic inhibitor at 1.8A1nm679.760.09
277THRBProthrombinP00734ignHUMAN THROMBIN-INHIBITOR COMPLEX1k2179.514.2
278THRBProthrombinP00734i502-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors2r2m81.9547.1
279THRBProthrombinP00734gozThrombin in Complex with a D-Phe-Pro-diaminopyridine derivative6hsx87.68no data
280THRBProthrombinP00734dkkCyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors3c2783.34no data
281THRBProthrombinP00734d6jThrombin in complex with (2R)-2-(benzylsulfonylamino)-N-((1S)-2-((4- carbamimidoylphenyl)methylamino)-1-methyl-2-oxo-ethyl)-N-methyl-3- phenyl-propanamide ethane4ufg80.57.
282THRBProthrombinP00734cdoTernary complex of an orally active thrombin inhibitor with human thrombin and a c-terminal hirudin derived exo-sit inhibitor2anm79.341.8
283THRBProthrombinP00734c7mthrombin inhibitors2c8w82.113.7
284THRBProthrombinP00734c5mthrombin inhibitors2c8x82.85220.
285THRBProthrombinP00734c1dDesign and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker2bxu86.2670.
286THRBProthrombinP00734bztCRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZOTHIOPHENE INHIBITOR 41d3d70.760.81
287THRBProthrombinP00734bt3CRYSTAL STRUCTURE OF HUMAN APLHA-THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 31d3p71.1641.
288THRBProthrombinP00734bt2CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 21d3q68.69290.
289THRBProthrombinP00734bt1CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 11d3t67.33no data
290THRBProthrombinP00734bliCRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR1jwt81.2514.
291THRBProthrombinP0073481aCrystal Structure Analysis of a novel Oxyguanidine bound to Thrombin1t4u77.13no data
292THRBProthrombinP007346v2Thrombin in complex with (2R)-2-(benzylsulfonylamino)-N-(2-((4- carbamimidoylphenyl)methylamino)-2-oxo-ethyl)-N-methyl-3-phenyl- propanamide4uff80.5911.
293THRBProthrombinP007346ovThrombin in complex with (S)-1-((R)-2-amino-3-cyclohexylpropanoyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide5jzy86.01no data
294THRBProthrombinP007344cpHuman thrombin complexed with fragment-based small molecules occupying the S1 pocket2bvr62.48200000.
295THRBProthrombinP007343zdThrombin in complex with (2R)-2-(benzylsulfonylamino)-N-(2-((4- carbamimidoylphenyl)methylamino)-2-oxo-butyl)-3-phenyl-propanamide4ufe80.137.
296THRBProthrombinP007343spOrally active thrombin inhibitors2fes80.890.98
297THRBProthrombinP0073434porally active thrombin inhibitors2feq80.271.39
298THRBProthrombinP0073433uBisphenylic Thrombin Inhibitors2zo377.390.1
299THRBProthrombinP0073432uThrombin Mutant A190S in complex with (S)-1-(D-phenylalanyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide5mm687.53no data
300THRBProthrombinP0073432uExploring Thrombin S1 pocket2zda86.324.
301THRBProthrombinP0073431uThrombin Inhibition2znk84.62no data
302THRBProthrombinP007342ceHuman thrombin complexed with fragment-based small molecules occupying the S1 pocket2bvs6780000.
303THRBProthrombinP0073429uThrombin Inhibition2zgx85.25180.
304THRBProthrombinP00734170crystal structue of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor1sl382.430.0014
305THRBProthrombinP00734166Novel Covalent Active Site Thrombin Inhibitors1qj189.189.
306THRBProthrombinP00734165Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics1sb176.12128.
307THRBProthrombinP00734163Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor1o0d76.796.2
308THRBProthrombinP00734162D-Phe-Pro-Arg-Type Thrombin Inhibitor1nzq80.1111.
309THRBProthrombinP00734121A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE1ghy93.338.
310THRBProthrombinP00734110CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE1g3778.220.1
311THRBProthrombinP007340zeHUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN1b5g74.4310.
312THRBProthrombinP007340kvThrombin inhibitors with rigid tripeptidyl aldehydes1ca879.290.32
313THRBProthrombinP007340ivTHROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES1bb080.344.4
314THRBProthrombinP0073400rSTRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTROPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P11d6w79.681100.
315THRBProthrombinP0073400nTHROMBIN COMPLEXED WITH A BETA-MIMETIC THIAZOLE-CONTAINING INHIBITOR1a6184.592.4
316THRBProthrombinP0073400lHUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN1a5g80.530.071
317THRBProthrombinP0073400kTHROMBIN COMPLEXED WITH HIRUGEN AND A BETA-STRAND MIMETIC INHIBITOR1a4676.882000.
318THRBProthrombinP00734baiRECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES1c1u81.665.6
319THRBProthrombinP00734bppCRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH 5-AMIDINOINDOLE-4-BENZYLPIPERIDINE INHIBITOR1d4p83.66500.
320THRBProthrombinP00734r11THROMBIN INHIBITOR COMPLEX1g3279.29780.
321THRBProthrombinP00734c24Thrombin Inhibitor Complex1kts78.73no data
322THRBProthrombinP00734c02Thrombin inhibitor complex1ktt83.461500.
323THRBProthrombinP00734cdbthrombin-hirugen_l-378,6501mu882.281.
324THRBProthrombinP00734cddThrombin-Hirugen-L405,4261mue81.322.3
325THRBProthrombinP00734cr9Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)1o5g83.1411000.
326THRBProthrombinP00734fsnCOMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR1oyt85.6457.
327THRBProthrombinP00734ppxCRYSTAL STRUCTURE OF THROMBIN COMPLEXED WITH AN GUANIDINE-MIMETIC INHIBITOR1qbv81.054100.
328THRBProthrombinP00734167Novel Covalent Active Site Thrombin Inhibitors1qj685.3918.
329THRBProthrombinP00734gr1Novel Covalent Active Site Thrombin Inhibitors1qj785.828.
330THRBProthrombinP0073414aCrystal Structure Analysis of a novel Oxyguanidine bound to Thrombin1t4v80.8121.
331THRBProthrombinP00734176Crystal structure of thrombin in complex with compound 11ta278.163.
332THRBProthrombinP00734177Crystal structure of thrombin in complex with compound 14b1ta681.380.74
333THRBProthrombinP00734minALPHA-THROMBIN COMPLEXED WITH HIRUGEN1tom80.115.
334THRBProthrombinP00734i11BOVINE THROMBIN--BM51.1011 COMPLEX1uvs78.234000.
335THRBProthrombinP00734shyComplex of thrombin with designed inhibitor 71651vzq85.9636.
336THRBProthrombinP00734uirThrombin Inhibitor Complex1ypg83.5110.
337THRBProthrombinP00734uipThrombin Inhibitor Complex1ype84.878.
338THRBProthrombinP00734uibThrombin Inhibitor Complex1ypj85.6795.
339THRBProthrombinP00734l17thrombin and P2 pyridine N-oxide inhibitor complex structure1z7183.970.66
340THRBProthrombinP00734382thrombin in complex with an oxazolopyridine inhibitor 211zgi79.764600.
341THRBProthrombinP00734062Thrombin in complex with an azafluorenyl inhibitor 23b1zrb77.94no data
342THRBProthrombinP00734c2dDesign and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker2bxt88.123.
343THRBProthrombinP00734c4mthrombin inhibitors2c9380.1112000.
344THRBProthrombinP00734eshComplex of recombinant human thrombin with an inhibitor2cf884.788.
345THRBProthrombinP00734348Complex of recombinant human thrombin with an inhibitor2cf984.2315.
346THRBProthrombinP00734f25Complex of Recombinant Human Thrombin with a Designed Inhibitor2cn085.8622.
347THRBProthrombinP00734701Human Thrombin Hirugen Inhibitor complex2jh080.952.
348THRBProthrombinP00734895Human Thrombin Hirugen Inhibitor complex2jh579.31367.
349THRBProthrombinP00734894Human Thrombin Hirugen Inhibitor complex2jh680.0617.
350THRBProthrombinP00734896Thrombin-hirugen-gw473178 ternary complex at 1.32A resolution2uuj85.75no data
351THRBProthrombinP00734897Thrombin-hirugen-gw420128 ternary complex at 1.39A resolution2uuk68.1no data
352THRBProthrombinP00734i25Thrombin with 3-cycle no F2v3h64no data
353THRBProthrombinP00734i26Thrombin with 3-cycle with F2v3o80.41no data
354THRBProthrombinP0073450uExploring thrombin S3 pocket2zg083.78no data
355THRBProthrombinP0073445uExploring thrombin S3 pocket2zfq85.3no data
356THRBProthrombinP0073446uExploring thrombin S3 pocket2zfr80.27no data
357THRBProthrombinP0073449uExploring thrombin S3 pocket2zhf81.63no data
358THRBProthrombinP0073437uExploring Thrombin S1 pocket2zdv83.03no data
359THRBProthrombinP0073451uExploring Thrombin S1 Pocket2zf083.8no data
360THRBProthrombinP0073419uThrombin Inibition2zfp82.436800.
361THRBProthrombinP0073412uExploring thrombin S3 pocket2zhw81.87no data
362THRBProthrombinP0073421uThrombin Inhibition2zgb84.97no data
363THRBProthrombinP0073427uThrombin Inhibition2zhq83.76no data
364THRBProthrombinP0073424uThrombin Inhibition2zi283.75no data
365THRBProthrombinP0073426uThrombin Inhibition2ziq85.87no data
366THRBProthrombinP0073411uHuman thrombin-in complex with UB-THR113biv81.27no data
367THRBProthrombinP0073413uExploring thrombin S3 pocket2zhe82.77no data
368THRBProthrombinP0073444uCrystal structure of thrombin in complex with inhibitor3da973.733100.
369THRBProthrombinP0073423uThrombin Mutant A190S in complex with (S) -1 - ((R) -2-amino-3,3-diphenylpropanoyl) -N- (3-chlorobenzyl) pyrrolidine-2-carboxamide5mjt81.28no data
370THRBProthrombinP0073423uBisphenylic Thrombin Inhibitors3dhk80.147.
371THRBProthrombinP0073416uUnderstanding Thrombin Inhibition3dt084.51no data
372THRBProthrombinP0073464uUnderstanding Thrombin Inhibition3dux83.88100.
373THRBProthrombinP0073491uThrombin Inhibition3f6878.758700.
374THRBProthrombinP0073410uHuman thrombin-in complex with UB-THR103biu84.73no data
375THRBProthrombinP0073499pThrombin Inhibition by Pyridin Derivatives3p1785.5833400.
376THRBProthrombinP0073410pThrombin Inhibition by Pyridin Derivatives3qto87.7774800.
377THRBProthrombinP0073406pThrombin Inhibition by Pyridin Derivatives3qtv87.7622500.
378THRBProthrombinP0073498pThrombin Inhibition by Pyridin Derivatives3qwc81.9355400.
379THRBProthrombinP0073402pThrombin Inhibition by Pyridin Derivatives3qx585.7563500.
380THRBProthrombinP00734s28Human Thrombin in complex with MI3283rlw85.8no data
381THRBProthrombinP00734s29Human Thrombin in complex with MI3293rly91.29no data
382THRBProthrombinP00734s54Human Thrombin in complex with MI3543rm053.24no data
383THRBProthrombinP00734m31Human Thrombin in complex with MI3313rml85.83no data
384THRBProthrombinP00734m32Human Thrombin in complex with MI3323rmm77.12no data
385THRBProthrombinP00734p97Human Thrombin In Complex With UBTHR973sha83.832600.
386THRBProthrombinP00734b01Human Thrombin In Complex With UBTHR1013shc82.991900.
387THRBProthrombinP00734b03Human Thrombin In Complex With UBTHR1033si387.1769300.
388THRBProthrombinP00734b04Human Thrombin In Complex With UBTHR1043si486.81132200.
389THRBProthrombinP00734p05Human Thrombin In Complex With UBTHR1053sv287.2764000.
390THRBProthrombinP007340bmHuman alpha-thrombin complexed with N-(methylsulfonyl)-D-phenylalanyl-N-((1-carbamimidoyl-4-piperidinyl)methyl)-l-prolinamide (BMS-189664)3tu783.158.17
391THRBProthrombinP007349muHuman thrombin - inhibitor complex4az277.6447.
392THRBProthrombinP00734mm9Thrombin in complex with inhibitor4bam84.91.14
393THRBProthrombinP00734n6lThrombin in complex with 1-(2R)-2-amino-3-phenyl-propanoyl-N-(2, 5dichlorophenyl)methylpyrrolidine-2-carboxamide4udw85.37no data
394THRBProthrombinP0073445sThrombin in complex with (S)-(4-chloro-2-((1-(5-methyl-1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxamido)methyl)phenyl)methanaminium4yes83.169.6
395THRBProthrombinP00734sjrThrombin in complex with 4-Methoxy-N-(2-pyridinyl)benzamide5af977.86no data
396THRBProthrombinP007346thThrombin in complex with (S)-1-((R)-2-amino-3-cyclohexylpropanoyl)-N-(5-chloro-2-(hydroxymethyl)benzy l)pyrrolidine-2-carboxamide5lce86.84no data
397THRBProthrombinP0073471uThrombin in complex with (S)-1-((R)-2-amino-3-cyclohexylpropanoyl)-N-(2-(aminomethyl)-5-chlorobenzyl) pyrrolidine-2-carboxamide5lpd88.43no data
398THRBProthrombinP0073422uThrombin in complex with Inhibitor2zc984.45180.
399THRBProthrombinP0073422uThrombin Mutant A190S in complex with (S)-1-(D-phenylalanyl)-N-(3-chlorobenzyl)pyrrolidine-2-carboxamide5mls85.35no data
400THRBProthrombinP00734apaCRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROMS RESOLUTION1aht89.4620.
401TPATissue-type plasminogen activatorP00750bbaCATALYTIC DOMAIN OF HUMAN TWO-CHAIN TISSUE PLASMINOGEN ACTIVATOR COMPLEX OF A BIS-BENZAMIDINE1a5h77.31500.
402TRYB2Tryptase beta-2P20231TPS2c4aHuman beta tryptase II with inhibitor CRA-284272fs972.823.
403TRYB2Tryptase beta-2P20231TPS2c3aHuman beta-tryptase II with inhibitor CRA-293822fs873.0925.
404TRYB2Tryptase beta-2P20231TPS2c3ahuman beta tryptase II complexed with activated ketone inhibitor CRA-293822fxr74.3725.
405TRYB2Tryptase beta-2P20231TPS25amHuman beta II tryptase with inhibitor CRA-275922gdd69.27no data
406TRYB2Tryptase beta-2P20231TPS2apaHUMAN BETA-TRYPTASE: A RING-LIKE TETRAMER WITH ACTIVE SITES FACING A CENTRAL PORE1a0l87.15no data
407TRYB2Tryptase beta-2P20231TPS25taTRYPTASE B2 IN COMPLEX WITH 5-(3-Aminomethyl-phenoxymethyl)-3-[3-(2-chloro-pyridin-3-ylethynyl)-phenyl]-oxazolidin-2-one; compound with trifluoro-acetic acid5f0371.01no data
408UROKUrokinase-type plasminogen activatorP00749ui1Substituted 2-Naphthamidine Inhibitors of Urokinase1sqa70.920.62
409UROKUrokinase-type plasminogen activatorP00749hmxuPA-HMA5za775.89no data
410UROKUrokinase-type plasminogen activatorP00749h55The crystal structure of uPA in complex with HMA-55F6ag770.79no data
411UROKUrokinase-type plasminogen activatorP00749eauuPA-6F-HMA5zae74.51no data
412UROKUrokinase-type plasminogen activatorP00749amrUROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-AMILORIDE COMPLEX1f5l84.25300.
413UROKUrokinase-type plasminogen activatorP007499xcCrystal structure of uPA in complex with 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide6ag359.7no data
414UROKUrokinase-type plasminogen activatorP007499x9uPA-HMA6ag274.71no data
415UROKUrokinase-type plasminogen activatorP0074932iuPA-31F5zaj71.21no data
416UROKUrokinase-type plasminogen activatorP0074928iuPA-BB2-28F5zaf67.15no data
417UROKUrokinase-type plasminogen activatorP00749239Substituted 2-Naphthamidine Inhibitors of Urokinase1owh75.0940.
418UROKUrokinase-type plasminogen activatorP00749239Crystal Structure of the Urokinase4fuc78.29no data
419UROKUrokinase-type plasminogen activatorP00749123A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE1gi966.086000.
420UROKUrokinase-type plasminogen activatorP00749133ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS1gj872.52110.
421UROKUrokinase-type plasminogen activatorP00749134ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS1gj976.7no data
422UROKUrokinase-type plasminogen activatorP00749135ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS1gja78.163800.
423UROKUrokinase-type plasminogen activatorP00749136ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS1gjd76.146000.
424UROKUrokinase-type plasminogen activatorP00749655Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors1o3p71.62220.
425UROKUrokinase-type plasminogen activatorP00749cr9Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)1o5c72.216000.
426UROKUrokinase-type plasminogen activatorP00749497Substituted 2-Naphthamidine inhibitors of urokinase1owd64.36.3
427UROKUrokinase-type plasminogen activatorP00749426Substituted 2-Naphthamidine Inhibitors of Urokinase1owi69.1428.
428UROKUrokinase-type plasminogen activatorP00749303Substituted 2-Naphthamidine Inhibitors of Urokinase1owk64.1923.5
429UROKUrokinase-type plasminogen activatorP00749745Substituted 2-Naphthamadine inhibitors of Urokinase1u6q70.131310.
430UROKUrokinase-type plasminogen activatorP007494pgUrokinase plasminogen activator B-chain-GPPE complex2r2w82.634000.
431UROKUrokinase-type plasminogen activatorP00749l1rFragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator2vip72.235200.
432UROKUrokinase-type plasminogen activatorP00749d55Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator2viq71.251300.
433UROKUrokinase-type plasminogen activatorP00749vg2Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator2viv63.21520.
434UROKUrokinase-type plasminogen activatorP00749d56Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator2viw68.7872.
435UROKUrokinase-type plasminogen activatorP00749qggUROKINASE-TYPE PLASMINOGEN ACTIVATOR INHIBITOR COMPLEX WITH A 1-(7- SULPHOAMIDOISOQUINOLINYL)GUANIDINE2vnt87.779.9
436UROKUrokinase-type plasminogen activatorP00749queCrystal structure of uPA in complex with quercetin5xg475.157000.
437UROKUrokinase-type plasminogen activatorP007497upCrystal Structure of the Urokinase4fue74.03no data
438UROKUrokinase-type plasminogen activatorP007499xfCrystal structure of uPA in complex with 3,5-bis(azanyl)-6-(1-benzofuran-2-yl)-N-carbamimidoyl-pyrazine-2- carboxamide6ag974.71no data
439UROKUrokinase-type plasminogen activatorP0074909iuPA-NU-09F5zc571.8no data
440UROKUrokinase-type plasminogen activatorP0074930iuPA-BB2-30F5zah65.61no data
441UROKUrokinase-type plasminogen activatorP0074994iuPA-BB2-94F5zag69.17no data
442UROKUrokinase-type plasminogen activatorP0074950iuPA-BB2-50F5za968.34no data
443UROKUrokinase-type plasminogen activatorP0074927iuPA-BB2-27F5za866.78no data
444UROKUrokinase-type plasminogen activatorP0074911eSynthesis of a Weak Basic uPA Inhibitor and Crystal Structure of Complex with uPA4h4276.34341000.
445UROKUrokinase-type plasminogen activatorP007491u9Crystal Structure of the Urokinase4fuj68.44no data
446UROKUrokinase-type plasminogen activatorP00749ui3Crystal Structure of the Urokinase4fui76.89no data
447UROKUrokinase-type plasminogen activatorP007499upCrystal Structure of the Urokinase4fug83.06no data
448UROKUrokinase-type plasminogen activatorP007498upCrystal Structure of the Urokinase4fuf79.94no data
449UROKUrokinase-type plasminogen activatorP007491upCrystal Structure of the Urokinase4fu779.58no data
450UROKUrokinase-type plasminogen activatorP00749ui3Substituted 2-Naphthamidine Inhibitors of Urokinase1sqt77.82630.
451UROKUrokinase-type plasminogen activatorP00749ui2Substituted 2-Naphthamidine Inhibitors of Urokinase1sqo85.3935.