The Ligandable Human Proteome

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Dihydrofolate reductase domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1DYRDihydrofolate reductaseP003749qrHuman dihydrofolate reductase complexed with NADPH and BT26a7e84.58no data
2DYRDihydrofolate reductaseP003749qoHuman dihydrofolate reductase complexed with NADPH and BT16a7c88.7no data
3DYRDihydrofolate reductaseP003741qzHuman dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine4keb88.56no data
4DYRDihydrofolate reductaseP00374prdSTRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4-DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS1boz87.93no data
5DYRDihydrofolate reductaseP00374mxaUnderstanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH1u7188.8833.
6DYRDihydrofolate reductaseP00374mxaMETHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS1dlr91.14no data
7DYRDihydrofolate reductaseP00374lihHUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9439), A LIPOPHILIC ANTIFOLATE1kms88.87no data
8DYRDihydrofolate reductaseP00374liiHUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE1kmv89.31112.
9DYRDihydrofolate reductaseP00374dtmAnalysis of Two Polymorphic Forms of a Pyrido[2,3-d]pyrimidine N9-C10 Reverse-Bridge Antifolate Binary Complex with Human Dihydrofolate Reductase1mvt88.03no data
10DYRDihydrofolate reductaseP00374dtmAnalysis of Two Polymorphic Forms of a Pyrido[2,3-d]pyrimidine N9-C10 Reverse-Bridge Antifolate Binary Complex with Human Dihydrofolate Reductase1mvs87.23no data
11DYRDihydrofolate reductaseP00374co4Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase1pd889.54no data
12DYRDihydrofolate reductaseP00374co4Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine antifolate Complex with Human Dihydrofolate Reductase1pd983.76no data
13DYRDihydrofolate reductaseP00374tqdStructure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry1s3v86.05no data
14DYRDihydrofolate reductaseP00374tqdStructure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry1s3u82.66no data
15DYRDihydrofolate reductaseP00374vg9HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)2w3b96.33no data
16DYRDihydrofolate reductaseP00374dh1Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes3fs690.34no data
17DYRDihydrofolate reductaseP00374dh1Structural Data for Human Active Site Mutant Enzyme Complexes3f9185.61no data
18DYRDihydrofolate reductaseP00374dh1Correlations of Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes3f8y91.86no data
19DYRDihydrofolate reductaseP00374dh1Human Dihydrofolate Reductase Structural Data with Active Site Mutant Enzyme Complexes3f8z88.32no data
20DYRDihydrofolate reductaseP00374tophuman dihydrofolate reductase Q35K/N64F double mutant binary complex with trimethoprim3s3v92.95593.
21DYRDihydrofolate reductaseP00374tophDHFR double mutant Q35S/N64F Trimethoprim Binary Complex3n0h91.18617.
22DYRDihydrofolate reductaseP00374topHUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM2w3a91.98no data
23DYRDihydrofolate reductaseP00374d2bPerferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase3nxo94.09no data
24DYRDihydrofolate reductaseP00374d2ePreferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E-and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase3nxt94.65no data
25DYRDihydrofolate reductaseP00374d2fPreferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase3nxv89.69no data
26DYRDihydrofolate reductaseP00374d2dPerferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase3nxr89.64no data
27DYRDihydrofolate reductaseP00374d2dPreferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro-2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase3nxx98.71no data
28DYRDihydrofolate reductaseP00374d2hPreferential Selection of Isomer Binding from Chiral Mixtures: Alernate Binding Modes Observed fro the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase3nxy93.08no data
29DYRDihydrofolate reductaseP00374oagStructural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants3l3r88.08no data
30DYRDihydrofolate reductaseP00374oaghDHFR-OAG binary complex4g9587.1124.4
31DYRDihydrofolate reductaseP00374oagStructural and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Thier Active Site Mutants3oaf84.71.6
32DYRDihydrofolate reductaseP00374684Human dihydrofolate reductase binary complex with PT6843s7a83.431.1
33DYRDihydrofolate reductaseP003749drHuman dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4-diamine4kd790.78no data
34DYRDihydrofolate reductaseP00374mmvHuman dihydrofolate reductase complexed with NADPH and P2184ddr92.84no data
35DYRDihydrofolate reductaseP00374ixfCrystal structure of human dihydrofolate reductase as complex with pyridopyrimidine 22 (N~6~-METHYL-N~6~-[4-(PROPAN-2-YL)PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)4qhv89.6no data
36DYRDihydrofolate reductaseP0037425uhuman dihydrofolate reductase complexed with NADPH and 5-{3-[3-(3,5-pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine4kbn90.09no data
37DYRDihydrofolate reductaseP003741r0Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]prop-1-yn-1-yl}6-ethylprimidine-2,4-diamine4kfj93.88no data
38DYRDihydrofolate reductaseP0037406uCrystal structure of human dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3S)-3-[3-methoxy-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)4kak93.27no data
39DYRDihydrofolate reductaseP0037465j6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl)5ht488.75no data
40DYRDihydrofolate reductaseP0037465o5-methyl-6-(1-naphthylthio)thieno[2,3-d]pyrimidine 2,4-diamine5hvb91.85no data
41DYRDihydrofolate reductaseP0037465q5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine5hve95.68no data
42DYRDihydrofolate reductaseP00374g6yHomo sapiens dihydrofolate reductase complexed with beta-NADPH and 3'-[(2R)-4-(2,4-diamino-6-ethylphenyl)but-3-yn-2-yl]-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid6de489.75no data