The Ligandable Human Proteome

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Ras guanine-nucleotide exchange factors catalytic domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1SOS1Son of sevenless homolog 1Q07889fvvRas:SOS:Ras in complex with a small molecule activator6d5w85.74no data
2SOS1Son of sevenless homolog 1Q07889fv7Ras:SOS:Ras in complex with a small molecule activator6d5h81.09no data
3SOS1Son of sevenless homolog 1Q07889ffyRas:SOS:Ras in complex with a small molecule activator6cur73.72no data
4SOS1Son of sevenless homolog 1Q07889ffvRas:SOS:Ras in complex with a small molecule activator6cup79.93no data
5SOS1Son of sevenless homolog 1Q07889ffsRas:SOS:Ras in complex with a small molecule activator6cuo79.02no data
6SOS1Son of sevenless homolog 1Q07889ec4Ras:SOS:Ras in complex with a small molecule activator6bvi67.38no data
7SOS1Son of sevenless homolog 1Q07889ebyRas:SOS:Ras in complex with a small molecule activator6bvl63.87no data
8SOS1Son of sevenless homolog 1Q07889ebvRas:SOS:Ras in complex with a small molecule activator6bvm64.26no data
9SOS1Son of sevenless homolog 1Q07889eavRas:SOS:Ras in complex with a small molecule activator6bvk63.12no data
10SOS1Son of sevenless homolog 1Q07889easRas:SOS:Ras in complex with a small molecule activator6bvj62.91no data
11SOS1Son of sevenless homolog 1Q07889bq5Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F16epm89.15no data
12SOS1Son of sevenless homolog 1Q07889axhRas guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor BAY-293 (compound 23)5ovi75.75no data
13SOS1Son of sevenless homolog 1Q07889axeRas guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 15ove69.03no data
14SOS1Son of sevenless homolog 1Q07889awzRas guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 185ovg67.91no data
15SOS1Son of sevenless homolog 1Q07889awwRas guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 215ovh73.8no data
16SOS1Son of sevenless homolog 1Q07889awtRas guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 175ovf72.5no data
17SOS1Son of sevenless homolog 1Q078895uxLigand-bound Ras:SOS:Ras complex5wfp84.34no data
18SOS1Son of sevenless homolog 1Q078895uvLigand-bound Ras:SOS:Ras complex5wfq83.73no data
19SOS1Son of sevenless homolog 1Q078895uuLigand-bound Ras:SOS:Ras complex5wfo83.35no data
20SOS1Son of sevenless homolog 1Q078892pxApproach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange4nyi66.58868000.
21SOS1Son of sevenless homolog 1Q078892pzApproach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange4nyj56.44322000.
22SOS1Son of sevenless homolog 1Q07889rv1The crystal structure of H-Ras and SOS in complex with ligands4ury95.786e+006
23SOS1Son of sevenless homolog 1Q078895uwLigand-bound Ras:SOS:Ras complex5wfr75.57no data
24SOS1Son of sevenless homolog 1Q07889fwaRas:SOS:Ras in complex with a small molecule activator6d5573.47no data
25SOS1Son of sevenless homolog 1Q07889fvjRas:SOS:Ras in complex with a small molecule activator6d5981.31no data
26SOS1Son of sevenless homolog 1Q07889fvgRas:SOS:Ras in complex with a small molecule activator6d5e84.81no data
27SOS1Son of sevenless homolog 1Q07889fvdRas:SOS:Ras in complex with a small molecule activator6d5g81.31no data
28SOS1Son of sevenless homolog 1Q07889fv4Ras:SOS:Ras in complex with a small molecule activator6d5j85.11no data
29SOS1Son of sevenless homolog 1Q07889fw7Ras:SOS:Ras in complex with a small molecule activator6d5l87.69no data
30SOS1Son of sevenless homolog 1Q07889fw4Ras:SOS:Ras in complex with a small molecule activator6d5m85.17no data
31SOS1Son of sevenless homolog 1Q07889fvyRas:SOS:Ras in complex with a small molecule activator6d5v89.97no data