The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	ACES	Acetylcholinesterase	P22303		lnd	Binary complex of native hAChE with oxime reactivator RS-170B	6o5v	74.48	no data
2	ACES	Acetylcholinesterase	P22303		lnd	Room temperature structure of binary complex of native hAChE with oxime reactivator RS-170B	6o5r	69.7	no data
3	ACES	Acetylcholinesterase	P22303		lnd	Room temperature structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B	6o5s	72.37	no data
4	ACES	Acetylcholinesterase	P22303		lnd	Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B	6o66	73.33	no data
5	ACES	Acetylcholinesterase	P22303		hlo	Human Acetylcholinesterase in complex with reactivator, HLo7	6nea	82.48	no data
6	ACES	Acetylcholinesterase	P22303		hi6	Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with EMPA and HI-6	6cqy	90.21	no data
7	ACES	Acetylcholinesterase	P22303		hi6	Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with VX(+) and HI-6	6cqv	87.39	no data
8	ACES	Acetylcholinesterase	P22303		hi6	Crystal Structure of Recombinant Human Acetylcholinesterase with Reactivator HI-6	6cqu	84.65	no data
9	ACES	Acetylcholinesterase	P22303		hi6	Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with VX(-) and HI-6	6cqw	89.04	no data
10	ACES	Acetylcholinesterase	P22303		e20	Binary complex of native hAChE with Donepezil	6o4w	90.6	no data
11	ACES	Acetylcholinesterase	P22303		e20	Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Donepezil	4ey7	86.18	no data
12	ACES	Acetylcholinesterase	P22303		gnt	Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with (-)-galantamine	4ey6	94	no data
13	ACES	Acetylcholinesterase	P22303		hi6	Crystal structure of human acetylcholinesterase in complex with paraoxon and HI6	5hf9	87.6	no data
14	CHLE	Cholinesterase	P06276	CHE1	huz	Human Butyrylcholinesterase in complex with ((S)-2-(butylamino)-N-(2-(4-(dimethylamino)cyclohexyl)ethyl)-3-(1H-indol-3-yl)propanamide	6qad	79.58	no data
15	CHLE	Cholinesterase	P06276	CHE1	huq	Human Butyrylcholinesterase in complex with (S)-N-(1-((2-cycloheptylethyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-N,N-dimethylbutan-1-aminium	6qab	82.13	no data
16	CHLE	Cholinesterase	P06276	CHE1	huk	Human Butyrylcholinesterase in complex with (S)-N2-butyl-N1-(2-cycloheptylethyl)-3-(1H-indol-3-yl)-N1,N2-dimethylpropane-1,2-diamine	6qae	81.91	no data
17	CHLE	Cholinesterase	P06276	CHE1	gz5	Human butyrylcholinesterase in complex with the R enantiomer of a chlorotacrine-tryptophan multi-target inhibitor.	6i0c	88.59	no data
18	CHLE	Cholinesterase	P06276	CHE1	by2	Butyrylcolinesterase expressed in CHO cells co-crystallised with a rivastigmine analogue	6eyf	85.14	no data
19	CHLE	Cholinesterase	P06276	CHE1	by2	Butyrylcolinesterase expressed in CHO cells co-crystallised with a rivastigmine analogue	6eul	85.06	no data
20	CHLE	Cholinesterase	P06276	CHE1	buw	Human butyrylcholinesterase in complex with ethopropazine	6eqp	84.02	1100.
21	CHLE	Cholinesterase	P06276	CHE1	9a5	Human butyrylcholinesterase in complex with the S enantiomer of a chlorotacrine-tryptophan multi-target inhibitor.	6i0b	86.8	no data
22	CHLE	Cholinesterase	P06276	CHE1	6qs	Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening	5k5e	87.59	443.
23	CHLE	Cholinesterase	P06276	CHE1	5hh	Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)naphthalene-2-sulfonamide	5dyy	87.53	56.9
24	CHLE	Cholinesterase	P06276	CHE1	5hf	Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)-N-(2-methoxyethyl)naphthalene-2-sulfonamide	5dyw	87.89	4.9
25	CHLE	Cholinesterase	P06276	CHE1	5hb	Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)-N-methylnaphthalene-2-sulfonamide	5dyt	87.73	25.
26	CHLE	Cholinesterase	P06276	CHE1	40v	X-ray structure of human butyrylcholinesterase in complex with N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-8-hydroxy-N-(2-methoxyethyl)-5-nitroquinoline-7-carboxamide	4xii	82.61	250.
27	CHLE	Cholinesterase	P06276	CHE1	3f9	Human butyrylcholinesterase in complex with N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide	4tpk	81.04	2.71
28	CHLE	Cholinesterase	P06276	CHE1	6yc	Human Butyrylcholinesterase complexed with N-Propargyliperidines	5lkr	73.8	3306.
29	CHLE	Cholinesterase	P06276	CHE1	cwq	Human Butyrylcholinesterase complexed with N-Propargyliperidines	6f7q	79.84	no data
30	EST1	Liver carboxylesterase 1	P23141	CES2 SES1	mvb	Crystal Structure of Human Liver Carboxylesterase in complex with cleavage products of Mevastatin	1ya8	59.12	no data
31	EST1	Liver carboxylesterase 1	P23141	CES2 SES1	htq	Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue	1mx5	96.79	no data
32	EST1	Liver carboxylesterase 1	P23141	CES2 SES1	htq	Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate	2dqz	59.33	no data
33	EST1	Liver carboxylesterase 1	P23141	CES2 SES1	chd	Crystal structure of human carboxylesterase in complex with cholate and palmitate	2dqy	49.21	no data

The Ligandable Human Proteome

Carboxylesterase, type B