Index | Gene Name Primary | Protein Name | Uniprot ID | Gene Name Synonym | Ligand Name | Structure | PDB Code | ligand desolvation | Ligand Structure | Compound Affinity nM |
1 | ITAL | Integrin alpha-L | P20701 | CD11A | la1 | X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution | 1xuo | 89.2 | | 69. |
2 | ITAL | Integrin alpha-L | P20701 | CD11A | bqn | LFA-1 I domain bound to inhibitors | 3bqn | 88.5 | | 2.5 |
3 | ITAL | Integrin alpha-L | P20701 | CD11A | bqm | LFA-1 I domain bound to inhibitors | 3bqm | 86.42 | | no data |
4 | ITAL | Integrin alpha-L | P20701 | CD11A | ab8 | X-ray structure of LFA-1 I-domain in complex with LFA878 at 2.1A resolution | 1xdg | 66.83 | | 50. |
5 | ITAL | Integrin alpha-L | P20701 | CD11A | 2ic | CD11a (LFA1) I-domain complexed with BMS-587101 aka 5-[(5S, 9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro [4.4]non-7-yl]methyl]-3-thiophenecarboxylicacid | 2ica | 74.99 | | 20. |
6 | ITAL | Integrin alpha-L | P20701 | CD11A | 803 | CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION | 1cqp | 79.39 | | 2400. |
7 | ITAM | Integrin alpha-M | P11215 | CD11B CR3A | sim | Structural basis for simvastatin competitive antagonism of complement receptor 3 | 4xw2 | 34.31 | | no data |