The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	SIR1	NAD-dependent protein deacetylase sirtuin-1	Q96EB6	SIR2L1	4i5	Crystal structure of the SIRT1 catalytic domain bound to NAD and an EX527 analog	4i5i	98.24	no data
2	SIR1	NAD-dependent protein deacetylase sirtuin-1	Q96EB6	SIR2L1	1ns	SIRT1/Activator/Inhibitor Complex	4zzi	90.53	no data
3	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	l5c	Crystal structure of Sirt2 in complex with selective inhibitor L5C	5yqo	94.4	no data
4	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	l55	Crystal structure of Sirt2 in complex with selective inhibitor L55	5yqn	92.54	no data
5	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	a2x	Crystal structure of Sirt2 in complex with selective inhibitor A29	5yqm	97.63	no data
6	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	8k9	Human SIRT2 in complex with a specific inhibitor, NPD11033	5y0z	90.55	no data
7	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	7kj	Structure of human Sirtuin 2 in complex with a selective thienopyrimidinone based inhibitor	5mat	86.93	580.
8	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	5gr	Crystal structure of human Sirt2 in complex with a SirReal probe fragment	5dy5	93.24	163.
9	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	5gn	Crystal structure of human Sirt2 in complex with a brominated 2nd generation SirReal inhibitor and NAD+	5dy4	96.58	no data
10	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	3te	Human Sirt2 in complex with SirReal2 and Ac-Lys-H3 peptide	4rmh	98.3	no data
11	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	3te	Human Sirt2 in complex with SirReal2 and NAD+	4rmg	96.32	no data
12	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	ocz	Crystal structure of human Sirt2 in complex with ADPR and EX-243	5d7p	94.16	no data
13	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	4i5	Crystal structure of human Sirt2 in complex with ADPR and CHIC35	5d7q	99.25	no data
14	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	3tk	Human Sirt2 in complex with SirReal1 and Ac-Lys-OTC peptide	4rmi	96.57	no data
15	SIR2	NAD-dependent protein deacetylase sirtuin-2	Q8IXJ6	SIR2L SIR2L2	8no	Crystal structure of human Sirtuin 2 in complex with a selective inhibitor	5y5n	98.03	1740.
16	SIR3	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	SIR2L3	ocz	CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND 2'-O-ACETYL-ADP-RIBOSE	4bvh	99.48	no data
17	SIR3	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	SIR2L3	ocz	CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND ADP-RIBOSE	4bvb	98.72	33400.
18	SIR3	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	SIR2L3	ocz	CRYSTAL STRUCTURE OF SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND NAD	4bv3	98.88	no data
19	SIR3	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	SIR2L3	1nq	Crystal Structure of human SIRT3 with ELT inhibitor 11c [N-{2-[1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl]ethyl}-N'-ethylthiophene-2,5-dicarboxamide]	4jsr	80.14	4.
20	SIR3	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	SIR2L3	1nr	Crystal Structure of human SIRT3 with ELT inhibitor 28 [4-(4-{2-[(2,2-dimethylpropanoyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide[	4jt8	84.51	33.
21	SIR3	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	SIR2L3	1ns	Crystal Structure of human SIRT3 with ELT inhibitor 3 [14-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide]	4jt9	93.3	7.2
22	SIR6	NAD-dependent protein deacetylase sirtuin-6	Q8N6T7	SIR2L6	7n2	Human Sirt6 in complex with activator UBCS38	5mgn	68.29	no data
23	SIR6	NAD-dependent protein deacetylase sirtuin-6	Q8N6T7	SIR2L6	7m2	Human Sirt6 in complex with activator UBCS039	5mf6	68.28	44000.

The Ligandable Human Proteome

Sirtuin family