The Ligandable Human Proteome

Home

SWIB/MDM2 domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1MDM2E3 ubiquitin-protein ligase Mdm2Q00987yincrystal structure of MDM2 with chromenotriazolopyrimidine 13jzk71.931230.
2MDM2E3 ubiquitin-protein ligase Mdm2Q00987y30Structure of a novel submicromolar MDM2 inhibitor4mdn76.05600.
3MDM2E3 ubiquitin-protein ligase Mdm2Q00987mi6Structure of human MDM2 protein in complex with Mi-63-analog3lbl75.4636.
4MDM2E3 ubiquitin-protein ligase Mdm2Q00987hu8HDM2 (17-111, WILDTYPE) COMPLEXED WITH COMPOUND 10 AT 1.21A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes6q9o83.19no data
5MDM2E3 ubiquitin-protein ligase Mdm2Q00987h28Crystal structure of MDM2 in complex with compound 13.6i3s80.65no data
6MDM2E3 ubiquitin-protein ligase Mdm2Q00987dizStructure of Human MDM2 in complex with a Benzodiazepine Inhibitor1t4e77.5580.
7MDM2E3 ubiquitin-protein ligase Mdm2Q009879qwHDM2 (17-111, WILD TYPE) COMPLEXED WITH NVP-HDM201 AT 1.56A5oc875.32no data
8MDM2E3 ubiquitin-protein ligase Mdm2Q009877hcMDM2 in complex with SAR4058385trf78.40.88
9MDM2E3 ubiquitin-protein ligase Mdm2Q009876ztDiscovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument5ln265.47no data
10MDM2E3 ubiquitin-protein ligase Mdm2Q009876ssDiscovery of New Natural-product-inspired Spiro-oxindole Compounds as Orally Active Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 6g5lay82.0534.
11MDM2E3 ubiquitin-protein ligase Mdm2Q009874thDiscovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors: Hdm2 (MDM2) complexed with cpd24zyi75.248.
12MDM2E3 ubiquitin-protein ligase Mdm2Q0098735sco-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID4qo475.475.
13MDM2E3 ubiquitin-protein ligase Mdm2Q009872u7Co-Crystal Structure of MDM2 with Inhibitor Compound 494ogv69.829.
14MDM2E3 ubiquitin-protein ligase Mdm2Q009872tzco-crystal structure of MDM2(17-111) in complex with compound 484occ862.
15MDM2E3 ubiquitin-protein ligase Mdm2Q009872twCo-crystal structure of MDM2 with Inhibitor Compound 44oba78.80.4
16MDM2E3 ubiquitin-protein ligase Mdm2Q009872swco-crystal structure of MDM2 (17-111) in complex with compound 254oas83.930.1
17MDM2E3 ubiquitin-protein ligase Mdm2Q009871mtCo-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide4jvr72.59no data
18MDM2E3 ubiquitin-protein ligase Mdm2Q009871mqCo-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid4jve72.4886.
19MDM2E3 ubiquitin-protein ligase Mdm2Q009871moCo-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one4jv967.31800.
20MDM2E3 ubiquitin-protein ligase Mdm2Q009871mnCo-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one4jv767.311000.
21MDM2E3 ubiquitin-protein ligase Mdm2Q009870r2crystal structure of MDM2 (17-111) in complex with compound 234ere73.54.2
22MDM2E3 ubiquitin-protein ligase Mdm2Q00987tj2Structure of a novel submicromolar MDM2 inhibitor3tj272.91no data
23MDM2E3 ubiquitin-protein ligase Mdm2Q009870y7Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors4hbm91.8412.
24MDM2E3 ubiquitin-protein ligase Mdm2Q009871myCo-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid4jwr74.3610.
25MDM2E3 ubiquitin-protein ligase Mdm2Q009876skNovel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) in complex with compound 6b5lav76.09819.