The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	fqq	Crystal structure of human KDM4A in complex with compound 19d	6h4w	74.98	no data
2	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	fqh	Crystal structure of human KDM4A in complex with compound 18a	6h4o	80.22	no data
3	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	fqe	Crystal structure of human KDM4A in complex with compound 16m	6h4s	76.97	no data
4	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	fqb	Crystal structure of human KDM4A in complex with compound 17f	6h4r	82.74	no data
5	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	fow	Crystal structure of human KDM4A in complex with compound 19a	6h4t	74.51	no data
6	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	fo8	Crystal structure of human KDM4A in complex with compound 17e	6h4y	82.1	no data
7	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	fo2	Crystal structure of human KDM4A in complex with compound 34a	6h4q	83.77	no data
8	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	kc6	Crystal structure of JMJD2A complexed with bipyridyl inhibitor	3pdq	76.39	180.
9	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	mmk	Crystal structure of human JMJD2A in complex with compound KDOAM20A	5fpv	86.96	no data
10	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	vao	Crystal structure of human JMJD2A in complex with compound 43	5a7n	83.17	no data
11	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	7wh	Crystal structure of human JMJD2A in complex with compound 42	5a7o	85.13	no data
12	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	6z1	Crystal structure of human JMJD2A in complex with compound 36	5a7p	76.13	no data
13	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	kch	Crystal structure of human JMJD2A in complex with compound 30	5a7q	84.15	no data
14	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	s2x	Crystal structure of human JMJD2A in complex with compound 44	5a7s	82.72	no data
15	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	35m	Crystal structure of human JMJD2A in complex with compound 35	5a7w	78.5	no data
16	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	9cj	Crystal structure of human JMJD2A in complex with compound 40	5a80	75.22	no data
17	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	5yq	inhibitors of JumonjiC domain-containing histone demethylases	5anq	87.49	3980.
18	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	5u8	Crystal structure of human KDM4A in complex with compound 52d	5f3c	77.86	900.
19	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	5uo	Crystal structure of human KDM4A in complex with compound 54a	5f3e	79.25	138.
20	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	5ul	Crystal structure of human KDM4A in complex with compound 53a	5f3g	69.52	126.
21	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	5uj	Crystal structure of human KDM4A in complex with compound 54j	5f3i	80.75	80.
22	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	5v1	Crystal Structure of human JMJD2A complexed with KDOOA011340	5f5i	94.04	950.
23	KDM4A	Lysine-specific demethylase 4A	O75164	JHDM3A JMJD2 JMJD2A KIAA0677	9dj	Crystal Structure of KDM4 with the Small Molecule Inhibitor QC6352	5vgi	75.46	104.
24	KDM4C	Lysine-specific demethylase 4C	Q9H3R0	GASC1 JHDM3C JMJD2C KIAA0780	mmk	Crystal structure of human JMJD2C catalytic domain in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino) -2-oxoethyl)amino)methyl)isonicotinic acid	5fjh	86.01	no data
25	KDM4D	Lysine-specific demethylase 4D	Q6B0I6	JHDM3D JMJD2D	cqt	Crystal Structure of KDM4D with tetrazole ligand GF049	6f5s	86.97	no data
26	KDM4D	Lysine-specific demethylase 4D	Q6B0I6	JHDM3D JMJD2D	5v0	Crystal Structure of human JMJD2D complexed with KDOAM16	5f5a	94.01	no data
27	KDM4D	Lysine-specific demethylase 4D	Q6B0I6	JHDM3D JMJD2D	5v3	Crystal Structure of human JMJD2D complexed with KDOPP7	5f5c	90.39	no data
28	KDM4D	Lysine-specific demethylase 4D	Q6B0I6	JHDM3D JMJD2D	yc8	Crystal structure of human KDM4D in complex with 3-(4- phenylbutanamido)pyridine-4-carboxylic acid	5fp4	86.39	no data
29	KDM4D	Lysine-specific demethylase 4D	Q6B0I6	JHDM3D JMJD2D	yc8	Crystal structure of human KDM4D in complex with 3-4-methylthiophen-2- yl methylaminopyridine-4-carboxylic acid	5fp7	86.39	no data
30	KDM4D	Lysine-specific demethylase 4D	Q6B0I6	JHDM3D JMJD2D	ha6	Crystal structure of human KDM4D in complex with 2-1H-pyrazol-4-yloxy- 3H,4H-pyrido-3,4-d-pyrimidin-4-one	5fpb	94.89	no data
31	KDM5A	Lysine-specific demethylase 5A	P29375	JARID1A RBBP2 RBP2	h6a	LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N67 i.e. 2-(5-phenyl-4-(phenyl(2-(piperidin-1-yl)ethoxy)methyl)-1H-pyrazol-1-yl)isonicotinic acid	6dqe	77.94	no data
32	KDM5A	Lysine-specific demethylase 5A	P29375	JARID1A RBBP2 RBP2	h61	LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N68 i.e. 2-(1-(2-(piperidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)thieno[3,2-b]pyridine-7-carboxylic acid	6dqf	66.33	no data
33	KDM5A	Lysine-specific demethylase 5A	P29375	JARID1A RBBP2 RBP2	lqt	Linked KDM5A Jmj Domain Bound to the Inhibitor 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinamid	5iwf	82.05	no data
34	KDM5A	Lysine-specific demethylase 5A	P29375	JARID1A RBBP2 RBP2	mmk	Linked KDM5A Jmj Domain Bound to the Inhibitor C49 (2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid)	5isl	78.78	52.
35	KDM5A	Lysine-specific demethylase 5A	P29375	JARID1A RBBP2 RBP2	90v	LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR (R)-N-(1-(3-isopropyl-1H-pyrazole-5-carbonyl)pyrrolidin-3-yl)cyclopropanecarboxamide (Compound N54)	6bh2	95.36	no data
36	KDM5A	Lysine-specific demethylase 5A	P29375	JARID1A RBBP2 RBP2	dqj	LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR (S)-N-(1-(3-isopropyl-1H-pyrazole-5-carbonyl)pyrrolidin-3-yl)cyclopropanecarboxamide (Compound N55)	6bh3	95.85	no data
37	KDM5B	Lysine-specific demethylase 5B	Q9UGL1	JARID1B PLU1 RBBP2H1	fqk	Crystal structure of human KDM5B in complex with compound 34f	6h51	84.37	no data
38	KDM5B	Lysine-specific demethylase 5B	Q9UGL1	JARID1B PLU1 RBBP2H1	b7z	Crystal structure of KDM5B in complex with S49365a.	6ein	72.13	no data
39	KDM5B	Lysine-specific demethylase 5B	Q9UGL1	JARID1B PLU1 RBBP2H1	90v	Crystal structure of KDM5B in complex with S49195a.	6ek6	91.76	no data
40	KDM5B	Lysine-specific demethylase 5B	Q9UGL1	JARID1B PLU1 RBBP2H1	wqs	Crystal structure of the catalytic domain of human JARID1B in complex with 3D fragment (5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yl)acetic acid (N09996a)	5fyt	91.6	no data
41	KDM5C	Lysine-specific demethylase 5C	P41229	DXS1272E JARID1C SMCX XE169	mmk	Crystal structure of human JARID1C in complex with KDM5-C49	5fwj	83.7	13.
42	KDM6A	Lysine-specific demethylase 6A	O15550	UTX	k0i	Crystal structure of UTX complexed with GSK-J1	6g8f	86.28	no data
43	KDM6B	Lysine-specific demethylase 6B	O15054	JMJD3 KIAA0346	yc8	Cell penetrant inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) families of histone lysine demethylases	5fp3	97.89	no data
44	KDM6B	Lysine-specific demethylase 6B	O15054	JMJD3 KIAA0346	k0i	CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1	4ask	81.19	60.
45	KDM7A	Lysine-specific demethylase 7A	Q6ZMT4	JHDM1D KDM7 KIAA1718	e67	E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase	3u78	67.99	2500.
46	UTY	Histone demethylase UTY	O14607	KDM6C	k0i	Crystal structure of JmjC domain of human histone demethylase UTY with bound GSK J1	3zpo	83.89	no data
47	UTY	Histone demethylase UTY	O14607	KDM6C	s2i	Crystal structure of JmjC domain of human histone demethylase UTY with S21056a	5a1l	81.89	no data
48	UTY	Histone demethylase UTY	O14607	KDM6C	mmk	Crystal structure of JmjC domain of human histone demethylase UTY in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid.	4uf0	71.89	no data

The Ligandable Human Proteome

JmjC domain