The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	ENPL	Endoplasmin	P14625	GRP94 TRA1	vc5	Structure of molecular chaperone Grp94 bound to selective inhibitor methyl 2-[2-(2-benzylphenyl)ethyl]-3-chloro-4,6-dihydroxybenzoate	6aom	85.7	630.
2	ENPL	Endoplasmin	P14625	GRP94 TRA1	vc1	Structure of molecular chaperone Grp94 bound to selective inhibitor methyl 3-chloro-2-(2-{2-[(4-fluorophenyl)methyl]phenyl}ethyl)-4,6-dihydroxybenzoate	6aol	82.96	540.
3	ENPL	Endoplasmin	P14625	GRP94 TRA1	gdm	GRP94 n-terminal domain bound to geldanamycin: effects of mutants 168-169 KS-AA	2esa	77.98	no data
4	ENPL	Endoplasmin	P14625	GRP94 TRA1	gdm	GRP94 N-terminal Domain bound to geldanamycin	2exl	79.99	no data
5	ENPL	Endoplasmin	P14625	GRP94 TRA1	cdy	Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with 2-chlorodideoxyadenosine	1qye	88.52	no data
6	ENPL	Endoplasmin	P14625	GRP94 TRA1	rdc	N-Domain Of Grp94 Lacking The Charged Domain In Complex With Radicicol	1u0z	88.88	no data
7	ENPL	Endoplasmin	P14625	GRP94 TRA1	rda	GRP94 in complex with the novel HSP90 Inhibitor Radamide	2gfd	84.22	520.
8	ENPL	Endoplasmin	P14625	GRP94 TRA1	rde	GRP94 in complex with the novel HSP90 Inhibitor Radester amine	2fyp	86.4	no data
9	ENPL	Endoplasmin	P14625	GRP94 TRA1	pa7	N-Domain Of Grp94, with the Charged Domain, In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine	6d1x	79.45	no data
10	ENPL	Endoplasmin	P14625	GRP94 TRA1	pa7	N-Domain Of Grp94 In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine	2gqp	84.11	no data
11	ENPL	Endoplasmin	P14625	GRP94 TRA1	nei	N-Domain Of Grp94 In Complex With the 2-Iodo-NECA	2h8m	91.2	no data
12	ENPL	Endoplasmin	P14625	GRP94 TRA1	p54	Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54	3o2f	94.4	no data
13	ENPL	Endoplasmin	P14625	GRP94 TRA1	2lc	Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity	4nh9	84.92	375.
14	ENPL	Endoplasmin	P14625	GRP94 TRA1	6c0	Crystal structure of Grp94 bound to methyl 3-chloro-2-(2-(1-((5-chlorofuran-2-yl)methyl)-1H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate, an inhibitor based on the BnIm and Radamide scaffolds.	5in9	88.8	440.
15	ENPL	Endoplasmin	P14625	GRP94 TRA1	7ky	Crystal structure of Grp94 bound to isoform-selective inhibitor methyl 2-(2-(1-(4-bromobenzyl)-1H-imidazol-2-yl)ethyl)-3-chloro-4,6-dihydroxybenzoate	5ttz	74.1	no data
16	ENPL	Endoplasmin	P14625	GRP94 TRA1	9qy	Structure of GRP94 N-terminal Domain bound to resorcinylic inhibitor BnIm.	5wmt	92.77	no data
17	ENPL	Endoplasmin	P14625	GRP94 TRA1	v2c	Structure of Grp94 with methyl 3-chloro-2-(2-(1-(2-ethoxybenzyl)-1 H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate, a Grp94-selective inhibitor and promising therapeutic lead for treating myocilin-associated glaucoma	6asp	86.24	no data
18	ENPL	Endoplasmin	P14625	GRP94 TRA1	vc4	Structure of Grp94 bound to methyl 2-[2-(2-benzylpyridin-3-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate, a pan-Hsp90 inhibitor	6asq	86.68	no data
19	ENPL	Endoplasmin	P14625	GRP94 TRA1	d57	Structure of GRP94 with a selective resorcinylic inhibitor.	6baw	90.05	no data
20	ENPL	Endoplasmin	P14625	GRP94 TRA1	eqd	Structure of GRP94 with a resorcinylic inhibitor.	6c91	90.32	no data
21	ENPL	Endoplasmin	P14625	GRP94 TRA1	nec	Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH NECA	1ysz	81.22	no data
22	ENPL	Endoplasmin	P14625	GRP94 TRA1	nec	Crystal Structure Of The N-Domain Of Grp94 Lacking The Charged Domain In Complex With Neca	1u2o	81.28	no data
23	ENPL	Endoplasmin	P14625	GRP94 TRA1	nec	Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with the specific ligand NECA	6d28	79.92	no data
24	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	zz5	Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone	2wi5	89.85	900.
25	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	zz4	Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone	2wi4	79.46	1560.
26	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	yuk	Crystal structure of Hsp90-alpha N-terminal domain in complex with 2-(4-Hydroxy-cyclohexylamino)-4-[5-(4-phenyl-imidazol-1-yl)-isoquinolin-1-yl]-benzamide	3wq9	89.03	no data
27	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	xkl	structure of HSP90 with an inhibitor bound	4bqj	83.6	no data
28	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	vj6	Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid	4jql	81.57	1000.
29	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	vha	Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor	3vha	78.17	40.
30	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	nec	Hsp90-alpha N-domain bound to NECA	6b99	79.68	no data
31	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	kfy	Hsp90-alpha S52A bound to PU-11-trans	6olx	82.77	no data
32	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	kfy	Hsp90-alpha bound to PU-11-trans	6n8x	83.79	no data
33	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	h71	Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H71	2fwz	80.45	50.
34	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	h0t	Hsp90 inhibitor desolvation as a rationale to steer on-rates and impact residence time	5od7	81.81	no data
35	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	gdm	GELDANAMYCIN BOUND TO THE HSP90 GELDANAMYCIN-BINDING DOMAIN	1yet	80.23	1200.
36	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	g5e	Hsp90 in complex with 5-(2,4-Dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazole-3-thione	6hhr	91.58	no data
37	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	fu7	Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide	3r4p	82.89	11.
38	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	fu3	Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide	3r4o	82.52	7.
39	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	fjs	Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6	5cf0	82.82	no data
40	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	dz8	Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-DZ8	2h55	80.87	no data
41	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	c8w	Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation	6f1n	82.93	no data
42	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	c4n	Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation	6ey9	84.75	no data
43	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	9zc	Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FS7	5xrd	82.71	no data
44	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	9un	Structure of HSP90 with NMS-E973 inhibitor bound	4b7p	77.58	0.346
45	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	99b	Complex of HSP90 ATPase domain with tropane derived inhibitors	4awo	90.05	24.
46	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	99a	Complex of HSP90 ATPase domain with tropane derived inhibitors	4awp	84.28	81.
47	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	72k	CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR200323.	5lq9	86.66	no data
48	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	70o	HSP90 WITH indazole derivative	5lo6	81.8	no data
49	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	70n	HSP90 WITH indazole derivative	5lo0	83.26	no data
50	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	4eq	Heat Shock Protein 90 Bound to CS307	4ykt	67.4	no data
51	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2r6	Identification of novel HSP90 / isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington s disease	4o09	91.15	20.
52	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2qa	Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease	4o0b	91.63	5.
53	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2kl	Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone	2wi7	75.26	58.
54	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2dd	3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone	2byi	89.13	461.
55	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	rdc	Human Hsp90-alpha ATPase domain bound to Radicicol	4egk	87.93	19.
56	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu4	Human Hsp90-alpha with 9-Butyl-8-(4-methoxy-benzyl)-9H-purin-6-ylamine	1uy7	80.11	200000.
57	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu5	Human Hsp90-alpha with 9-Butyl-8-(3-trimethoxy-benzyl)-9H-purin-6ylamine	1uy8	82.05	75000.
58	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu6	Human Hsp90-alpha with 8-Benzo[1,3]dioxol-,5-ylmethyl-9-butyl-9H-purin-6-ylamine	1uy9	80.63	15300.
59	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu7	Human Hsp90-alpha with 9-Butyl-8-(2,5-dimethoxy-benzyl)-9H-purin-6-ylamine	1uyc	82.89	41000.
60	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu8	Human Hsp90-alpha with 9-Butyl-8-(2-chloro-3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine	1uyd	85.54	200000.
61	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu9	Human Hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl)-9-pent-4-ylnyl-9H-purin-6-ylamine	1uye	86.18	200000.
62	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu1	Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation	6el5	86.61	no data
63	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu1	Human Hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl)-2-fluoro-9-pent-4-ylnyl-9H-purin-6-ylamine	1uyf	85.36	30000.
64	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu2	Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine	1uyg	88.37	53500.
65	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu0	Human Hsp90-alpha with 9-Butyl-8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine	1uyh	82.71	14300.
66	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	puz	Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9-pent-9H-purin-6-ylamine	1uyi	85.44	4100.
67	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pux	Human Hsp90-alpha with 8-Benzo[1,3]dioxol-,5-ylmethyl-9-butyl-2-fluoro-9H-purin-6-ylamine	1uyk	82.12	17100.
68	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pu3	Human Hsp90-alpha with 9-Butyl-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine	1uy6	80.12	200000.
69	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	4bc	Crystal Structures of human HSP90alpha complexed with dihydroxyphenylpyrazoles	1yc1	83.26	680.
70	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	4bc	Crystal Structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles	1yc3	81.85	no data
71	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	ct5	Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design	2bt0	88.83	no data
72	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2d7	3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone	2byh	87.75	258.
73	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	4bh	HUMAN HSP90 WITH 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-3-YL)- BENZENE-1,2-DIOL	2ccs	92.33	2000.
74	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2e1	HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL- 2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE	2cct	89.58	9500.
75	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2d9	HUMAN HSP90 WITH 4-CHLORO-6-(4-(4-(4-METHANESULPHONYL-BENZYL)- PIERAZIN-1-YL)-1H-PYRAZOL-3-YL)-BENZENE-1,3-DIOL	2ccu	77.8	740.
76	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	h64	Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H64	2fwy	76.99	200.
77	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	a94	HSP90 complexed with A943037	2qg0	83.9	1900.
78	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	a91	HSP90 complexed with A917985	2qg2	86.82	4000.
79	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2gg	Inhibition of the HSP90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs	2uwd	87.12	4.5
80	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2gj	4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer	2vci	82.9	21.
81	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2eq	4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer	2vcj	80.49	21.
82	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	zz6	Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone	2wi6	84.43	230.
83	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	vhd	Structure of HSP90 with an inhibitor bound	2xab	82.85	0.54
84	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2dl	Structure of HSP90 with small molecule inhibitor bound	2xdl	92.17	790000.
85	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	c0p	Structure of HSP90 with small molecule inhibitor bound	2xhr	81.43	4.8
86	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	c0y	Structure of HSP90 with small molecule inhibitor bound	2xht	89.8	1100.
87	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	t5m	Structure of HSP90 with small molecule inhibitor bound	2xhx	82.51	250.
88	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	xjg	Structure of HSP90 with small molecule inhibitor bound	2xjg	81.2	15.
89	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	xjx	Structure of HSP90 with small molecule inhibitor bound	2xjx	65.23	0.71
90	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	yjw	Tricyclic series of Hsp90 inhibitors	2yk2	86.64	no data
91	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	yjw	Tricyclic series of Hsp90 inhibitors	2yjw	90.36	7600.
92	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	ykb	Tricyclic series of Hsp90 inhibitors	2ykb	92.57	1100.
93	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	yke	Tricyclic series of Hsp90 inhibitors	2yke	90.34	1100.
94	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	p4a	Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation	6eln	92.52	no data
95	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	cxz	Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90	3bmy	83.16	30.
96	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	snx	Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90	3d0b	87.15	290.
97	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	py9	Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone	3ekr	86.31	30.
98	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	moj	Structure of HSP90 bound with a noval fragment.	3ft8	87.91	30.
99	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	bd0	HSP90 N-terminal domain in complex with 1-{4-[(2R)-1-(5-chloro-2,4-dihydroxybenzoyl)pyrrolidin-2-yl]benzyl}-3,3-difluoropyrrolidinium	3hek	86.04	5.4
100	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	819	Human heat-shock protein 90 (HSP90) in complex with {4-[3-(2,4-dihydroxy-5-isopropyl-phenyl)-5-thioxo- 1,5-dihydro-[1,2,4]triazol-4-yl]-benzyl}-carbamic acid ethyl ester {ZK 2819}	3hhu	83.63	41.
101	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	z64	Crystal structure of Hsp90 with fragment Z064	3hz5	86.89	no data
102	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	jzb	HSP90 N-TERMINAL DOMAIN with pochoxime A	3inw	89.04	no data
103	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	jzc	HSP90 N-TERMINAL DOMAIN with pochoxime B	3inx	89.04	no data
104	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	4cd	HSP90 N-terminal domain in complex with 4-chloro-6-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol	3k97	84.62	10.
105	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	1rc	HSP90 N-terminal domain in complex with (1R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide	3k98	81.16	1.
106	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	pft	HSP90 N-terminal domain in complex with 4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diol	3k99	87.23	60.
107	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	sd1	Crystal Structure of Benzamide SNX-1321 bound to Hsp90	3mnr	85.19	no data
108	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	p54	Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor PU-H54	3o0i	85.86	no data
109	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	bsm	Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design	2bsm	86.65	no data
110	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	bsm	Crystal Structure of HSP90 with VER-49009	3owb	87.16	19.
111	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	94m	HSP90A N-terminal domain in complex with BIIB021	3qdd	88.07	1.7
112	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	05s	Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity	3qtf	87.14	110.
113	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	fu5	Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide	3r4n	79.02	130.
114	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	06h	Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.	3r91	90.26	92.
115	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	06t	Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor capable of significantly decreasing tumor volume in a mouse xenograft model.	3rkz	83.25	83.
116	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	vhc	Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor	3vhc	80.62	1.3
117	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	vhe	Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor, CH5164840	3vhd	80.19	0.52
118	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	wha	Hsp90 alpha N-terminal domain in complex with a tricyclic inhibitor	3wha	83.49	0.48
119	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	592	Complex of HSP90 ATPase domain with tropane derived inhibitors	4awq	83.06	479.
120	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	h05	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor	4cwf	82.96	32400.
121	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	6lv	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor	4cwn	86.42	2600.
122	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	t62	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor	4cwo	89.36	6100.
123	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	tv2	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor	4cwp	85.12	170.
124	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	haj	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor	4cwr	85.55	5.
125	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	g3r	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor	4cws	83.47	12.
126	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	ik9	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor	4cwt	81.97	179.
127	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	efu	Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid benzyl-methyl-amide	4efu	89.28	250.
128	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	rl1	Crystal structure of Human Hsp90 with RL1	4l8z	84.73	no data
129	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	rl3	Crystal structure of Human Hsp90 with RL3	4l90	84.3	no data
130	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	s36	Crystal structure of Human Hsp90 with S36	4l93	79.61	no data
131	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	s46	Crystal structure of Human Hsp90 with S46	4l94	84.48	no data
132	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	fj2	Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2	4lwe	80.69	70.
133	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	fj4	Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ4	4lwg	81.22	no data
134	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	fj5	Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5	4lwh	79.07	27.
135	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	fj6	Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6	4lwi	85.15	23.
136	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	e0g	Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity	4nh7	96.16	4.
137	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2lc	Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity	4nh8	90.69	3.
138	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2q8	Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease	4o04	87.49	690.
139	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	2q9	Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease	4o05	89.25	37.
140	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	fgh	Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease	4o07	89.69	42.
141	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	jr9	Crystal structure of Human Hsp90 with JR9	4r3m	84.56	no data
142	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	990	Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990	4u93	88.07	13.
143	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	3jc	Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990	4w7t	82.56	900.
144	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	40w	Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors	4xip	92.44	235.
145	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	40y	Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors	4xiq	92.58	86.
146	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	40x	Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors	4xir	89.37	115.
147	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	40z	Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors	4xit	85.61	54.
148	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	4et	Heat Shock Protein 90 Bound to CS318	4ykx	88.37	no data
149	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	4ev	Heat Shock Protein 90 Bound to CS320	4ykz	85.58	no data
150	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	tql	Dynamic Undocking and the Quasi-Bound State as tools for Drug Design	5fnf	81.61	700000.
151	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	7ft	Hsp90 alpha N-terminal domain in complex with an inhibitor	5h22	83.24	no data
152	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	6g7	Crystal Structure of Hsp90-alpha N-domain in complex with 5-(2,4-Dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one	5j64	91.66	no data
153	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	6gc	HSP90 in complex with N-Butyl-5-[4-(2-fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-methyl-benzamide	5j9x	88	no data
154	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	6gc	Crystal Structure of Hsp90-alpha N-domain in complex with N-Butyl-5-[4-(2-fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-methyl-benzamide	5j6l	89.07	no data
155	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	6fj	HSP90 in complex with 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-N-furan-2-ylmethyl-2,4-dihydroxy-N-methyl-benzamide	5j20	87.3	no data
156	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	6fj	Crystal Structure of Hsp90-alpha N-domain L107 mutant in complex with 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-N-furan-2-ylmethyl-2,4-dihydroxy-N-methyl-benzamide	5j6m	87.54	no data
157	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	6ff	HSP90 in complex with 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-methyl-N-propyl-benzenesulfonamide	5j27	86.68	no data
158	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	6ff	Crystal Structure of Hsp90-alpha N-domain L107A mutant in complex with 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-methyl-N-propyl-benzenesulfonamide	5j6n	87.06	no data
159	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	6gw	Crystal Structure of Hsp90-alpha N-domain in complex with 2,4-Dihydroxy-N-methyl-5-(5-oxo-4-o-tolyl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-N-thiophen-2-ylmethyl-benzamide	5j86	91.25	no data
160	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	70k	HSP90 WITH indazole derivative	5lny	81.3	no data
161	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	70z	HSP90 WITH indazole derivative	5lnz	82.25	no data
162	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	70l	HSP90 WITH indazole derivative	5lo1	84.32	no data
163	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	70m	HSP90 WITH indole derivative	5lo5	92.28	no data
164	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	72y	CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003498614A.	5lr1	87.46	no data
165	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	73s	CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003492875	5lrl	89.17	no data
166	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	73z	CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR166475	5ls1	87.23	no data
167	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	7f9	Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase	5m4e	87.31	no data
168	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	7fx	Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase	5m4h	89.38	no data
169	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	9ek	Crystal Structure of Hsp90-alpha N-Domain in complex with Indazole derivative	5nyh	80.72	no data
170	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	9r8	Human Heat Shock Protein 90 bound to 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide	5oci	81.7	no data
171	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	9rz	Crystal Structure of Hsp90-alpha N-Domain in complex with Indazole derivative	5odx	87.39	no data
172	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	74e	CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR148019.	5t21	87.13	no data
173	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	9qy	Structure of human Hsp90-alpha bound to resorcinylic inhibitor BnIm	5vyy	86.47	no data
174	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	8cf	Crystal structure of Human Hsp90 with FS2	5xqd	85.48	no data
175	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	8co	Crystal structure of Human Hsp90 with FS3	5xqe	77.57	no data
176	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	8cr	Crystal structure of Human Hsp90 with FS4	5xr5	80.29	no data
177	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	8cu	Crystal structure of Human Hsp90 with FS6	5xr9	80.53	no data
178	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	8du	Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5	5xrb	80.06	no data
179	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	jx1	Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor JX1	5xre	83.07	no data
180	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	d57	Structure of Hsp90 NTD with a GRP94-selective resorcinylic inhibitor.	6ceo	87.76	no data
181	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	b5q	Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation	6ei5	79.82	no data
182	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	baw	Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation	6elo	91.23	no data
183	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	ba8	Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation	6elp	83.65	no data
184	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	c4t	Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation	6ey8	89.86	no data
185	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	c4k	Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation	6eya	89.11	no data
186	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	c3z	Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation	6eyb	87.37	no data
187	HS90A	Heat shock protein HSP 90-alpha	P07900	HSP90A HSPC1 HSPCA	4eu	Heat Shock Protein 90 Bound to CS319	4yky	87.06	no data
188	HS90B	Heat shock protein HSP 90-beta	P08238	HSP90B HSPC2 HSPCB	kfy	Hsp90-beta bound to PU-11-trans	6n8y	82.67	no data
189	HS90B	Heat shock protein HSP 90-beta	P08238	HSP90B HSPC2 HSPCB	pu3	Human Hsp90-beta with PU3 (9-Butyl-8(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine)	1uym	84.39	1000.
190	HS90B	Heat shock protein HSP 90-beta	P08238	HSP90B HSPC2 HSPCB	7pp	Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor	3nmq	79.09	0.2
191	HS90B	Heat shock protein HSP 90-beta	P08238	HSP90B HSPC2 HSPCB	83s	Hsp90b N-terminal domain with inhibitors	5uc4	82.32	no data
192	HS90B	Heat shock protein HSP 90-beta	P08238	HSP90B HSPC2 HSPCB	871	Hsp90b N-terminal domain with inhibitors	5uch	83.98	no data
193	HS90B	Heat shock protein HSP 90-beta	P08238	HSP90B HSPC2 HSPCB	874	Hsp90b N-terminal domain with inhibitors	5uci	85.25	no data
194	HS90B	Heat shock protein HSP 90-beta	P08238	HSP90B HSPC2 HSPCB	ku3	Hsp90b N-terminal domain with inhibitors	5ucj	83.94	no data
195	PDK2	[Pyruvate dehydrogenase	Q15119	PDHK2	sz6	VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context- dependent cytostasis in cancer cells	4v25	72.03	84.
196	PDK2	[Pyruvate dehydrogenase	Q15119	PDHK2	7tj	VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context- dependent cytostasis in cancer cells	4v26	71.64	no data
197	PDK2	[Pyruvate dehydrogenase	Q15119	PDHK2	7fw	Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase	5m4m	77.99	no data
198	PDK2	[Pyruvate dehydrogenase	Q15119	PDHK2	7fv	Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase	5m4n	63.78	no data
199	PDK2	[Pyruvate dehydrogenase	Q15119	PDHK2	7fe	Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase	5m4p	73.51	no data
200	PDK2	[Pyruvate dehydrogenase	Q15119	PDHK2	pft	Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PA7	4mp7	83.05	1827.
201	PDK2	[Pyruvate dehydrogenase	Q15119	PDHK2	pv1	Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PA1	4mp2	81.26	3570.
202	PDK2	[Pyruvate dehydrogenase	Q15119	PDHK2	p35	Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS35	5j71	73.89	110.
203	PDK2	[Pyruvate dehydrogenase	Q15119	PDHK2	7f9	Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase	5m4k	75.88	2170.
204	PDK3	[Pyruvate dehydrogenase	Q15120	PDHK3	rdc	Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol	2q8i	79.31	400000.
205	PDK4	[Pyruvate dehydrogenase	Q16654	PDHK4	p4a	Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4	2zdx	77.8	648000.

The Ligandable Human Proteome

Histidine kinase/HSP90-like ATPase