The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	GSTA1	Glutathione S-transferase A1	P08263		eaa	GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID	1gsf	88.97	10000.
2	GSTA2	Glutathione S-transferase A2	P09210	GST2	asd	Glutathione transferase A2-2 in complex with delta-4-andostrene-3-17- dione	2vct	65.16	no data
3	GSTA3	Glutathione S-transferase A3	Q16772		asd	Glutathione transferase A3-3 in complex with glutathione and delta-4- androstene-3-17-dione	2vcv	89.56	no data
4	GSTO1	Glutathione S-transferase omega-1	P78417	GSTTLP28	xx0	Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(morpholinosulfonyl)phenyl)acetamide	6pnm	88.77	no data
5	GSTO1	Glutathione S-transferase omega-1	P78417	GSTTLP28	orm	Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-isopropylsulfamoyl)phenyl)acetamide	6pno	80.38	no data
6	GSTO1	Glutathione S-transferase omega-1	P78417	GSTTLP28	or7	Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-(2-methoxyethyl)-N-methylsulfamoyl)phenyl)acetamide	6pnn	82.16	no data
7	GSTO1	Glutathione S-transferase omega-1	P78417	GSTTLP28	jrd	Glutathione S-Transferase Omega 1 bound to covalent inhibitor 44	6mhd	80.75	no data
8	GSTO1	Glutathione S-transferase omega-1	P78417	GSTTLP28	4g9	Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-27	4yqm	83.57	31.
9	GSTO1	Glutathione S-transferase omega-1	P78417	GSTTLP28	4gb	Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-31	4yqu	80.24	221.
10	GSTO1	Glutathione S-transferase omega-1	P78417	GSTTLP28	85p	Structure of GSTO1 covalently conjugated to quinolinic acid fluorosulfate	5ueh	82.57	no data
11	GSTO1	Glutathione S-transferase omega-1	P78417	GSTTLP28	4gg	Glutathione S-transferase Omega 1 bound to covalent inhibitor C4-10	4yqv	83.39	1950.
12	GSTO1	Glutathione S-transferase omega-1	P78417	GSTTLP28	jr7	Glutathione S-Transferase Omega 1 bound to covalent inhibitor 18	6mhb	87.65	no data
13	GSTP1	Glutathione S-transferase P	P09211	FAEES3 GST3	sas	GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE	13gs	69.29	24000.
14	GSTP1	Glutathione S-transferase P	P09211	FAEES3 GST3	eaa	Crystal Structure of Glutathione Transferase Pi Y108V Mutant in Complex with the Glutathione Conjugate of Ethacrynic Acid	3hjo	76.84	300.
15	GSTP1	Glutathione S-transferase P	P09211	FAEES3 GST3	eaa	Structure of human Glutathione Transferase Pi class in complex with Ethacraplatin	3n9j	65.18	no data
16	GSTP1	Glutathione S-transferase P	P09211	FAEES3 GST3	eaa	Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate (Grown in the Absence of the Reducing Agent DTT)	3kmo	78.05	no data
17	GSTP1	Glutathione S-transferase P	P09211	FAEES3 GST3	eaa	Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate	3km6	77.17	no data
18	GSTP1	Glutathione S-transferase P	P09211	FAEES3 GST3	eaa	HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH ETHACRYNIC ACID	2gss	66.06	11500.
19	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	hql	Crystal structure analysis of human hematopoietic prostaglandin D synthase complexed with HQL-79	2cvd	75.81	800.
20	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	d27	Complex structure of prostaglandin D2 synthase at 2.2A.	2vd0	86.6	11600.
21	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	d28	Complex structure of prostaglandin D2 synthase at 2.25A.	2vd1	86.54	138.
22	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	nzo	Structure of human prostaglandin D-synthase (hGSTS1-1) in complex with nocodazole	3ee2	78.83	65000.
23	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	kxo	An orally active inhibitor bound at the active site of HPGDS	3kxo	86.61	no data
24	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	7pq	Crystal structure of hH-PGDS with water displacing inhibitor	4ec0	73.14	845.
25	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	9pq	Crystal structure of hH-PGDS with water displacing inhibitor	4edy	81.57	1480.
26	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	0o5	Crystal structure of hH-PGDS with water displacing inhibitor	4edz	85.26	8.26
27	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	0o4	Crystal structure of hH-PGDS with water displacing inhibitor	4ee0	76.57	2.34
28	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	cwc	Complex of human hematopoietic prostagandin D2 synthase (hH-PGDS) in complex with an active site inhibitor.	5ais	82.19	570.
29	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	krx	Complex of human hematopoietic prostagandin D2 synthase (hH-PGDS) in complex with an active site inhibitor.	5aix	89.74	12.
30	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	93c	Crystal structure of hematopoietic prostaglandin D synthase in complex with F092	5ywx	84.15	no data
31	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	ux4	Crystal structure of hematopoietic prostaglandin D synthase in complex with U004	5yx1	83.59	no data
32	HPGDS	Hematopoietic prostaglandin D synthase	O60760	GSTS PGDS PTGDS2	kcd	hPGDS complexed with a quinoline-3-carboxamide	6n4e	85.23	no data
33	PGES2	Prostaglandin E synthase 2	Q9H7Z7	C9orf15 PGES2	imn	Microsomal prostaglandin E synthase type-2	1z9h	84.96	1e+006

The Ligandable Human Proteome

Glutathione S-transferase, N-terminal