The Ligandable Human Proteome

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Oxoglutarate/iron-dependent dioxygenase

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1EGLN1Egl nine homolog 1Q9GZT9C1orf12ku1Hypoxia-Inducible Factor (HIF) Prolyl Hydroxylase 2 (PHD2) in Complex with the Carboxamide Analog JNJ430581716nmq87.98no data
2EGLN1Egl nine homolog 1Q9GZT9C1orf124hgCellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)2g1982.671400.
3EGLN1Egl nine homolog 1Q9GZT9C1orf124hgCellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)2g1m83.77no data
4EGLN1Egl nine homolog 1Q9GZT9C1orf1242zPHD2-R717 with 407874223oui83.412600.
5EGLN1Egl nine homolog 1Q9GZT9C1orf12qnmHIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and 2-(4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid4bqw85.9633.
6EGLN1Egl nine homolog 1Q9GZT9C1orf12fntHIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Fe(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]alanine4bqy89.161100.
7EGLN1Egl nine homolog 1Q9GZT9C1orf124jrStructure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors4jzr71.6615.8
8EGLN1Egl nine homolog 1Q9GZT9C1orf121qaCrystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetylamino}-phenyl-acetic acid4kbz90.35no data
9EGLN1Egl nine homolog 1Q9GZT9C1orf12un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)5lat87.33no data
10EGLN1Egl nine homolog 1Q9GZT9C1orf12un9PHD2:Fe:UN9:partial HIF1-alpha substrate complex3hqu88.39no data
11EGLN1Egl nine homolog 1Q9GZT9C1orf12un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)5lb687.37no data
12EGLN1Egl nine homolog 1Q9GZT9C1orf12un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)5lbb87.42no data
13EGLN1Egl nine homolog 1Q9GZT9C1orf12un9S-nitrosylated PHD2 (GSNO soaked) in complex with Zn(II) and UN92y3387.88no data
14EGLN1Egl nine homolog 1Q9GZT9C1orf12un9S-nitrosylated PHD2 (NO exposed) in complex with Fe(II) and UN92y3488.9280.
15EGLN1Egl nine homolog 1Q9GZT9C1orf12un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)5lbf88.42no data
16EGLN1Egl nine homolog 1Q9GZT9C1orf12un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)5lbe87.6no data
17EGLN1Egl nine homolog 1Q9GZT9C1orf12un9Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor2hbu88.44no data
18EGLN1Egl nine homolog 1Q9GZT9C1orf12un9Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor2hbt88.32no data
19EGLN1Egl nine homolog 1Q9GZT9C1orf12un9HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)4bqx88.18300.
20EGLN1Egl nine homolog 1Q9GZT9C1orf12un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)5lbc88.31no data
21EGLN1Egl nine homolog 1Q9GZT9C1orf12un9HIF prolyl hydroxylase 2 (PHD2/ EGLN1) D315E VARIANT in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)4uwd86.06no data
22EGLN1Egl nine homolog 1Q9GZT9C1orf12a1zHIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Vadadustat5ox676.7629.