The Ligandable Human Proteome

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Kelch repeat type 1

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL19l6iStructure of the Keap1 Kelch domain in complex with a small molecule inhibitor.5fnu76.561.3
2KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL19j8hSmall molecule inhibitor of the KEAP1-NRF2 protein-protein interaction6qmk76.82no data
3KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL19j6qSmall molecule inhibitor of the KEAP1-NRF2 protein-protein interaction6qme72.68no data
4KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL19j6kSmall molecule inhibitor of the KEAP1-NRF2 protein-protein interaction6qmj74.6no data
5KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL19j6hSmall molecule inhibitor of the KEAP1-NRF2 protein-protein interaction6qmc81.38no data
6KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL19fuuCrystal Structure of Keap1 in Complex with Synthetic Small Molecular based on a co-crystallization3vng51.53no data
7KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL19fuuCrystal Structure of Keap1 Soaked with Synthetic Small Molecular3vnh76.28no data
8KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL1912oCrystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes4ifn71.45no data
9KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL191vwStructure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione4l7c73.257400.
10KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL191vxStructure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid4l7d76.28750.
11KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL192fsSTRUCTURE OF KEAP1 KELCH DOMAIN WITH(1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-Yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-Carbonyl]cyclohexane-1-carboxylic acid4n1b73.721100.
12KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL19xyyStructure of the Keap1 Kelch domain in complex with a small molecule inhibitor.5fns79.844000.
13KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL190plStructure of the Keap1 Kelch domain in complex with a small molecule inhibitor.5fnt77.97670.
14KEAP1Kelch-like ECH-associated protein 1Q14145INRF2 KIAA0132 KLHL19xmsStructure of the Keap1 Kelch domain in complex with a small molecule inhibitor.5fnr78.6559000.