The Ligandable Human Proteome

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Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1GRIA2Glutamate receptor 2P42262GLUR2qsnCrystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity3r7x65.25no data
2GRIA2Glutamate receptor 2P42262GLUR2m1lThe structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns12092cmo73.96394.
3GRIA2Glutamate receptor 2P42262GLUR208wCrystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR23ua866.7714.
4GRIA2Glutamate receptor 2P42262GLUR2cpwX-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 1.85 A RESOLUTION.1syh99.66393.
5GRIA2Glutamate receptor 2P42262GLUR2cpwX-RAY STRUCTURE OF THE Y702F MUTANT OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 2.1 A RESOLUTION.1syi99.543590.
6GRIA2Glutamate receptor 2P42262GLUR24zkCrystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution5cbr98.341800.
7GRID2Glutamate receptor ionotropic, delta-2O43424GLURD2ckaSTRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE IONOTROPIC GLUTAMATE RECEPTOR-LIKE GLUD2 IN COMPLEX WITH 7-CKA5cc290.7680000.
8GRIK1Glutamate receptor ionotropic, kainate 1P39086GLUR5ubeCrystal structure of the GluR5 ligand binding core dimer in complex with UBP316 at 1.76 Angstroms resolution2qs371.87no data
9GRIK1Glutamate receptor ionotropic, kainate 1P39086GLUR5l5hStructure of GluK1 ligand-binding domain (S1S2) in complex with N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl benzamide at 2.3 A resolution6sbt68.97no data
10GRIK1Glutamate receptor ionotropic, kainate 1P39086GLUR5ec8Structure of GluK1 ligand-binding domain in complex with N-(7-fluoro-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)-2-hydroxybenzamide at 1.85 A resolution6fz471.87no data
11GRIK1Glutamate receptor ionotropic, kainate 1P39086GLUR53huCrystal Structure of the Ligand Binding Domain of GluK1 in Complex with an Antagonist (S)-1-(2'-Amino-2'-carboxyethyl)-3-[(2-carboxythien-3-yl)methyl]thieno[3,4-d]pyrimidin-2,4-dione at 2.5 A Resolution3s2v83.92157.
12GRIK1Glutamate receptor ionotropic, kainate 1P39086GLUR5sxiCrystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist4mf382.24no data
13GRIK1Glutamate receptor ionotropic, kainate 1P39086GLUR535kStructure of GluK1 ligand-binding domain (S1S2) in complex with (S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid at 2.28 A resolution4qf978.4637100.
14GRIK1Glutamate receptor ionotropic, kainate 1P39086GLUR54e7Structure of the ligand-binding domain of GluK1 in complex with the antagonist CNG101114ymb90.31620.
15NMDE1Glutamate receptor ionotropic, NMDA 2AQ12879NMDAR2A2jlCrystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and PPDA4nf679.49no data