The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	HDAC2	Histone deacetylase 2	Q92769		iwx	HDAC2 WITH LIGAND BRD4884	5iwg	93.4	346.
2	HDAC2	Histone deacetylase 2	Q92769		6ez	HDAC2 WITH LIGAND BRD7232	5ix0	91.82	519.
3	HDAC2	Histone deacetylase 2	Q92769		el8	Crystal structure of human HDAC2 in complex with (R)-6-[3,4-Dioxo-2-(4-trifluoromethoxy-phenylamino)-cyclobut-1-enylamino]-heptanoic acid hydroxyamide	6g3o	66.86	no data
4	HDAC4	Histone deacetylase 4	P56524	KIAA0288	ebe	Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor	6fyz	78.58	no data
5	HDAC4	Histone deacetylase 4	P56524	KIAA0288	tfg	Structure of HDAC4 catalytic domain (a double cysteine-to-alanine mutant) bound to a trifluoromethylketone inhbitor	2vqq	95.03	no data
6	HDAC4	Histone deacetylase 4	P56524	KIAA0288	tfg	Structure of HDAC4 catalytic domain bound to a trifluoromethylketone inhbitor	2vqj	55.14	367.
7	HDAC4	Histone deacetylase 4	P56524	KIAA0288	tfg	Structure of HDAC4 catalytic domain with a gain-of-function muation bound to a trifluoromethylketone inhbitor	2vqo	93.86	no data
8	HDAC4	Histone deacetylase 4	P56524	KIAA0288	ha3	Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor	2vqm	50.05	978.
9	HDAC4	Histone deacetylase 4	P56524	KIAA0288	kee	Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease	4cby	76.3	20.
10	HDAC4	Histone deacetylase 4	P56524	KIAA0288	otf	Potent, selective and CNS-penetrant tetrasubstituted cyclopropane class IIa histone deacetylase (HDAC) inhibitors	5a2s	78.77	20.
11	HDAC7	Histone deacetylase 7	Q8WUI4	HDAC7A	nu9	HDAC7 bound with inhibitor TMP269	3znr	79.28	36.
12	HDAC7	Histone deacetylase 7	Q8WUI4	HDAC7A	nu7	HDAC7 bound with TFMO inhibitor tmp942	3zns	75.97	39.
13	HDAC8	Histone deacetylase 8	Q9BY41	HDACL1	gok	Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat	6hsk	63.23	no data
14	HDAC8	Histone deacetylase 8	Q9BY41	HDACL1	0di	Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor	3sff	78.77	200.
15	HDAC8	Histone deacetylase 8	Q9BY41	HDACL1	1di	Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor	3sfh	85.44	90.
16	HDAC8	Histone deacetylase 8	Q9BY41	HDACL1	l6g	Crystal structure of S39D HDAC8 in complex with a largazole analogue.	4rn0	87.23	255.
17	HDAC8	Histone deacetylase 8	Q9BY41	HDACL1	l8g	Crystal structure of S39D HDAC8 in complex with a largazole analogue.	4rn1	86.94	10000.
18	HDAC8	Histone deacetylase 8	Q9BY41	HDACL1	l7g	Crystal structure of S39D HDAC8 in complex with a largazole analogue.	4rn2	77.4	1500.
19	HDAC8	Histone deacetylase 8	Q9BY41	HDACL1	nhb	Crystal structure of inhibited human HDAC8	1w22	91.85	175.5

The Ligandable Human Proteome

Histone deacetylase domain