The Ligandable Human Proteome

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Isopropylmalate dehydrogenase-like domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1IDHCIsocitrate dehydrogenase [NADP] cytoplasmicO75874PICDdwgNovel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd136bl177.38no data
2IDHCIsocitrate dehydrogenase [NADP] cytoplasmicO75874PICD59dCrystal structure of human IDH1 in complex with GSK321A5de190.52no data
3IDHCIsocitrate dehydrogenase [NADP] cytoplasmicO75874PICD6n3Crystal structure of Iso-citrate Dehydrogenase R132H in complex with a novel inhibitor (compound 13a)5l5775.05no data
4IDHCIsocitrate dehydrogenase [NADP] cytoplasmicO75874PICD70qIDH1 R132H in complex with IDH1465sun71.87no data
5IDHCIsocitrate dehydrogenase [NADP] cytoplasmicO75874PICDdwpNovel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd16bkx76.25no data
6IDHCIsocitrate dehydrogenase [NADP] cytoplasmicO75874PICDdwjNovel Modes of Inhibition of Wild-Type IDH1:Direct Covalent Modification of His315 with Cmpd116bl076.43no data
7IDHCIsocitrate dehydrogenase [NADP] cytoplasmicO75874PICDdwsNovel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd156bl275.14no data