The Ligandable Human Proteome

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Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA1752pd9Crystal structure of human FTO in complex with small-molecule inhibitors6ak492.83no data
2FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA17528s3Crystal structure of RNA dioxygenase bound with an inhibitor6akw87.94no data
3FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA17527ycCrystal structure of human FTO in complex with small-molecule inhibitors6aej91.84no data
4FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA1752640Crystal structure of human FTO in complex with acylhydrazine inhibitor 164cxx93.132110.
5FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA1752dgrCrystal structure of human FTO in complex with acylhydrazine inhibitor 214cxy95.8211800.
6FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA1752jmsCrystal structure of FTO bound to a selective inhibitor4qkn83.84no data
7FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA1752nkgCrystal structure of an oxygenase in complex with inhibitor cco0104qho94.07no data
8FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA1752un9Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)4ie693.782800.
9FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA175258wCrystal structure of FTO-IN1155dab70.3no data
10FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA1752rhnCrystal structure of the human fat mass and obesity associated protein (FTO) in complex with citrate and rhein (RHN)4ie783.359000.
11FTOAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1KIAA17523dtCrystal structure of the fat mass and obesity associated (FTO) protein reveals basis for its substrate specificity3lfm85.7no data