The Ligandable Human Proteome

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Histone-lysine N-methyltransferase DOT1 domain

IndexGene Name PrimaryProtein NameUniprot IDGene Name SynonymLigand NameStructurePDB Codeligand desolvationLigand StructureCompound Affinity nM
1DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT4sx0Crystal structure of Dot1l in complex with a brominated SAH analog3sx098.92no data
2DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT4aw3Crystal Structure of human DOT1L in complex with inhibitor SGC09474er781.68no data
3DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT4aw1Crystal Structure of human DOT1L in complex with inhibitor FED14er083.59no data
4DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT4aw0Crystal structure of human DOT1L in complex with inhibitor FED24eqz92.41no data
5DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT45ekCrystal structure of Dot1L in complex with inhibitor CPD3 [N-(1-(2-chlorophenyl)-1H-indol-6-yl)-2-(2-(5-(2-chlorophenyl)-1H-tetrazol-1-yl)acetyl)hydrazinecarboxamide]5dry89.520.
6DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT40qkCrystal Structure of DOT1L in complex with EPZ0047774eki90.350.1
7DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT40qkCrystal Structure of Human DOT1L in complex with inhibitor EPZ0047774er387.03no data
8DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT40qjCrystal Structure of DOT1L in Complex with EPZ0036964ekg90.461.7
9DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT4ep4Crystal structure of DOT1L in complex with EPZ0000044ek992.4738000.
10DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT4adnCrystal structure of Dot1L in complex with adenosine and inhibitor CPD1 [N6-(2,6-dichlorophenyl)-N6-(pent-2-yn-1-yl)quinoline-4,6-diamine]5mvs77.43no data
11DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT45idCrystal structure of Dot1l in complex with 5-iodotubercidin3uwp84.66no data
12DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT45egCrystal structure of Dot1L in complex with inhibitor CPD2 [2-(2-(5-((2-chlorophenoxy)methyl)-1H-tetrazol-1-yl)acetyl)-N-(4-chlorophenyl)hydrazinecarboxamide]5drt85.644400.
13DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specificQ8TEK3KIAA1814 KMT45f6Crystal structure of Dot1L in complex with inhibitor CPD3 [(2,6-dichlorophenyl)(quinolin-6-yl)methanone]5dtq91.9139000.