The Ligandable Human Proteome

Index	Gene Name Primary	Protein Name	Uniprot ID	Gene Name Synonym	Ligand Name	Structure	PDB Code	ligand desolvation	Compound Affinity nM
1	ANM5	Protein arginine N-methyltransferase 5	O14744	HRMT1L5 IBP72 JBP1 SKB1	cux	Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors	6k1s	99.02	no data
2	ANM5	Protein arginine N-methyltransferase 5	O14744	HRMT1L5 IBP72 JBP1 SKB1	mta	Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide	5fa5	98.22	no data
3	ANM5	Protein arginine N-methyltransferase 5	O14744	HRMT1L5 IBP72 JBP1 SKB1	3xv	Crystal structure of PRMT5:MEP50 with EPZ015666 and SAM	4x61	91.59	1.
4	ANM5	Protein arginine N-methyltransferase 5	O14744	HRMT1L5 IBP72 JBP1 SKB1	3xv	Crystal structure of PRMT5:MEP50 with EPZ015666 and sinefungin	4x60	93.42	1.
5	ANM5	Protein arginine N-methyltransferase 5	O14744	HRMT1L5 IBP72 JBP1 SKB1	4z2	Crystal structure of PRMT5:MEP50 with EPZ015866 and sinefungin	5c9z	94.37	no data
6	ANM5	Protein arginine N-methyltransferase 5	O14744	HRMT1L5 IBP72 JBP1 SKB1	5qj	Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin	5emj	89.91	33.
7	ANM5	Protein arginine N-methyltransferase 5	O14744	HRMT1L5 IBP72 JBP1 SKB1	5qh	Crystal structure of PRMT5:MEP50 with Compound 9 and sinefungin	5emk	92.12	13.
8	ANM5	Protein arginine N-methyltransferase 5	O14744	HRMT1L5 IBP72 JBP1 SKB1	5qk	Crystal structure of PRMT5:MEP50 with Compound 10 and SAM	5eml	91.76	23.
9	ANM5	Protein arginine N-methyltransferase 5	O14744	HRMT1L5 IBP72 JBP1 SKB1	5ql	Crystal structure of PRMT5:MEP50 with Compound 15 and sinefungin	5emm	91.47	18.
10	ANM5	Protein arginine N-methyltransferase 5	O14744	HRMT1L5 IBP72 JBP1 SKB1	f5j	Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity	6ckc	96.87	no data

The Ligandable Human Proteome

PRMT5 arginine-N-methyltransferase