The Ligandable Human Proteome

SH2 domain

Index	Gene Name Primary	Uniprot ID	Protein Name	Gene Name Synonym	PDB codes
1	ABL1	P00519	Tyrosine-protein kinase ABL1	ABL JTK7	2abl 2fo0 3k2m 3t04 3uyo 4xey 5dc0 5dc4 5dc9 5mo4
2	ABL2	P42684	Tyrosine-protein kinase ABL2	ABLL ARG	4eih
3	CHN1	P15882	N-chimaerin	ARHGAP2 CHN	3cxl
4	CRK	P46108	Adapter molecule crk		5jn0
5	CSK	P41240	Tyrosine-protein kinase CSK		3eac 3eaz
6	FER	P16591	Tyrosine-protein kinase Fer	TYK3	6kc4
7	FES	P07332	Tyrosine-protein kinase Fes/Fps	FPS	3bkb 3cbl 3cd3 4e93 6jmf
8	FYN	P06241	Tyrosine-protein kinase Fyn		1g83 4u17 4u1p
9	GRAP2	O75791	GRB2-related adapter protein 2	GADS GRB2L GRID	5gjh
10	GRB10	Q13322	Growth factor receptor-bound protein 10	GRBIR KIAA0207	1nrv
11	GRB14	Q14449	Growth factor receptor-bound protein 14		2aug
12	GRB2	P62993	Growth factor receptor-bound protein 2	ASH	1bm2 1bmb 1cj1 1fyr 1jyq 1jyr 1jyu 1tze 1zfp 2aoa 2aob 2h46 2huw 3c7i 3imd 3imj 3in7 3in8 3kfj 3mxc 3mxy 3n7y 3n84 3n8m 3ov1 3ove 3s8l 3s8n 3s8o 3wa4 4p9v 4p9z 5cdw 6icg 6ich
13	GRB7	Q14451	Growth factor receptor-bound protein 7		2qms 3pqz 4wwq 4x6s 5d0j 5eel 5eeq 5tyi 5u06 5u1q
14	HCK	P08631	Tyrosine-protein kinase HCK		1ad5 1qcf 2c0i 2c0o 2c0t 2hck 3nhn 3vry 3vrz 3vs0 3vs1 3vs2 3vs3 3vs4 3vs5 3vs6 4lud 4u5w 5h09 5h0b 5h0e 5h0g 5h0h
15	JAK1	P23458	Tyrosine-protein kinase JAK1	JAK1A JAK1B	5ixd 5ixi 5l04
16	JAK2	O60674	Tyrosine-protein kinase JAK2		6e2p 6e2q
17	LCK	P06239	Tyrosine-protein kinase Lck		1bhf 1bhh 1cwd 1cwe 1fbz 1ijr 1lcj 1lck 1lkk 1lkl 1x27 4d8k 5mtm 5mtn
18	MATK	P42679	Megakaryocyte-associated tyrosine-protein kinase	CTK HYL	1jwo 3us4
19	NCK1	P16333	Cytoplasmic protein NCK1	NCK	2ci8 2ci9
20	NCK2	O43639	Cytoplasmic protein NCK2	GRB4	2cia
21	PIK3R1	P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	GRB1	1h9o 2iug 2iuh 2iui 3hhm 4jps 4l1b 4l23 4l2y 4ovu 4waf 4zop 5aul 5fi4 5gji 5m6u 5uk8 5ukj 5ul1 5xgh 5xgi 5xgj
22	PLCG1	P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	PLC1	3gqi 4ey0 4fbn 5eg3 5tqs
23	PTPN11	Q06124	Tyrosine-protein phosphatase non-receptor type 11	PTP2C SHPTP2	2shp 3tkz 3tl0 4dgp 4dgx 4gwf 4h1o 4h34 4je4 4jeg 4nwf 4nwg 4ohd 4ohe 4ohh 4ohi 4ohl 4qsy 5df6 5ehp 5ehr 5i6v 5ibm 5ibs 5x7b 5x94 5xzr 6atd 6bmr 6bmu 6bmv 6bmw 6bmx 6bmy 6bn5 6cmp 6cmq 6cmr 6cms 6crf 6crg 6md7 6md9 6mda 6mdb 6mdc 6mdd 6ihz
24	PTPN6	P29350	Tyrosine-protein phosphatase non-receptor type 6	HCP PTP1C	2b3o
25	SH2B2	O14492	SH2B adapter protein 2	APS	1rqq
26	SH2D1A	O60880	SH2 domain-containing protein 1A	DSHP SAP	1d1z 1d4t 1d4w 1m27
27	SH2D1B	O14796	SH2 domain-containing protein 1B	EAT2	5kaz
28	SHC1	P29353	SHC-transforming protein 1	SHC SHCA	1mil
29	SLA2	Q9H6Q3	Src-like-adapter 2	C20orf156 SLAP2	4m4z
30	SOCS2	O14508	Suppressor of cytokine signaling 2	CIS2 SSI2 STATI2	2c9w 4jgh 5bo4 6i4x 6i5j 6i5n
31	SOCS4	Q8WXH5	Suppressor of cytokine signaling 4	SOCS7	2izv
32	SOCS6	O14544	Suppressor of cytokine signaling 6	CIS4 SOCS4	2vif
33	SRC	P12931	Proto-oncogene tyrosine-protein kinase Src	SRC1	1a07 1a08 1a09 1a1a 1a1b 1a1c 1a1e 1fmk 1ksw 1o41 1o42 1o43 1o44 1o45 1o46 1o47 1o48 1o49 1o4a 1o4b 1o4c 1o4d 1o4e 1o4f 1o4g 1o4h 1o4i 1o4j 1o4k 1o4l 1o4m 1o4n 1o4o 1o4p 1o4q 1o4r 1shd 1y57 2h8h 2src 4f59 4f5a 4f5b 4k11
34	STAP1	Q9ULZ2	Signal-transducing adaptor protein 1	BRDG1	3maz
35	STAT1	P42224	Signal transducer and activator of transcription 1-alpha/beta		1bf5 1yvl
36	STAT3	P40763	Signal transducer and activator of transcription 3	APRF	6qhd
37	STAT6	P42226	Signal transducer and activator of transcription 6		4y5u
38	SUPT6H	Q7KZ85	Transcription elongation factor SPT6	KIAA0162 SPT6H	6gme
39	SYK	P43405	Tyrosine-protein kinase SYK		1a81 4fl2 4fl3
40	TYK2	P29597	Non-receptor tyrosine-protein kinase TYK2		4po6
41	VAV2	P52735	Guanine nucleotide exchange factor VAV2		4roj
42	YES1	P07947	Tyrosine-protein kinase Yes	YES	5mtj
43	ZAP70	P43403	Tyrosine-protein kinase ZAP-70	SRK	1m61 2oq1 2ozo 4k2r 4xz0 4xz1