The Ligandable Human Proteome

Serine proteases, trypsin domain

Index	Gene Name Primary	Uniprot ID	Protein Name	Gene Name Synonym	PDB codes
1	AZU1	P20160	Azurocidin		1a7s 1ae5 1fy1 1fy3
2	C1R	P00736	Complement C1r subcomponent		1gpz 1md8 2qy0
3	C1S	P09871	Complement C1s subcomponent		1elv 4j1y 5ubm
4	C2	P06681	Complement C2		2i6q 2i6s 2odp 2odq
5	CFB	P00751	Complement factor B	BF BFD	1dle 1rrk 1rs0 1rtk 2ok5 3hrz 3hs0 6qsw 6qsx 6rav
6	CFD	P00746	Complement factor D	DF PFD	1bio 1dfp 1dic 1dst 1dsu 1fdp 1hfd 2xw9 2xwa 4cbn 4cbo 4d9q 4d9r 5fbe 5fbi 5fck 5mt0 5mt4 5nar 5nat 5naw 5nb6 5nb7 5nba 6fty 6ftz 6fug 6fuh 6fui 6fuj 6fut 6qmr 6qmt
7	CFI	P05156	Complement factor I	IF	2xrc
8	CMA1	P23946	Chymase	CYH CYM	1klt 1nn6 1pjp 1t31 2hvx 3n7o 3s0n 4afq 4afs 4afu 4afz 4ag1 4ag2 4k2y 4k5z 4k60 4k69 4kp0 5yjm 5yjp
9	CTRC	Q99895	Chymotrypsin-C	CLCR	4h4f
10	CTSG	P08311	Cathepsin G		1au8 1cgh 1t32
11	ELANE	P08246	Neutrophil elastase	ELA2	1b0f 1h1b 1hne 1ppf 1ppg 2rg3 2z7f 3q76 3q77 4nzl 4wvp 5a09 5a0a 5a0b 5a0c 5a8x 5a8y 5a8z 5abw 6f5m 6e69
12	F10	P00742	Coagulation factor X		1c5m 1ezq 1f0r 1f0s 1fax 1fjs 1g2l 1hcg 1ioe 1iqe 1iqg 1iqh 1iqi 1iqj 1iql 1iqm 1iqn 1ksn 1lpg 1lpk 1lpz 1lqd 1mq5 1mq6 1nfu 1nfw 1nfx 1nfy 1p0s 1v3x 1wu1 1xka 1xkb 1z6e 2bmg 2boh 2bok 2bq6 2bq7 2bqw 2cji 2d1j 2ei6 2ei7 2ei8 2fzz 2g00 2h9e 2j2u 2j34 2j38 2j4i 2j94 2j95 2jkh 2p16 2p3t 2p3u 2p93 2p94 2p95 2phb 2pr3 2q1j 2ra0 2uwl 2uwo 2uwp 2vh0 2vh6 2vvc 2vvu 2vvv 2vwl 2vwm 2vwn 2vwo 2w26 2w3i 2w3k 2wyg 2wyj 2xbv 2xbw 2xbx 2xby 2xc0 2xc4 2xc5 2y5f 2y5g 2y5h 2y7x 2y7z 2y80 2y81 2y82 3cen 3cs7 3ens 3ffg 3hpt 3iit 3k9x 3kl6 3kqb 3kqc 3kqd 3kqe 3liw 3m36 3m37 3q3k 3sw2 3tk5 3tk6 4a7i 4bti 4btt 4btu 4y6d 4y71 4y76 4y79 4y7a 4y7b 4zh8 4zha 5k0h 5voe 5vof
13	F11	P03951	Coagulation factor XI		1xx9 1xxd 1xxf 1zhm 1zhp 1zhr 1zjd 1zlr 1zmj 1zml 1zmn 1zom 1zpb 1zpc 1zpz 1zrk 1zsj 1zsk 1zsl 1ztj 1ztk 1ztl 2f83 2fda 3bg8 3sor 3sos 4cr5 4cr9 4cra 4crb 4crc 4crd 4cre 4crf 4crg 4d76 4d7f 4d7g 4na7 4na8 4ty6 4ty7 4wxi 4x6m 4x6n 4x6o 4x6p 4y8x 4y8y 4y8z 5e2o 5e2p 5eok 5exl 5exm 5exn 5i25 5q0d 5q0e 5q0f 5q0g 5q0h 5qck 5qcl 5qcm 5qcn 5tks 5tkt 5tku 5wb6 6aod 6c0s 6i58 6r8x 5qqo 5qqp 6hhc
14	F12	P00748	Coagulation factor XII		4xde 4xe4 6b74 6b77 6gt6
15	F2	P00734	Prothrombin		1a2c 1a3b 1a3e 1a46 1a4w 1a5g 1a61 1abi 1abj 1ad8 1ae8 1afe 1aht 1ai8 1aix 1awf 1awh 1ay6 1b5g 1b7x 1ba8 1bb0 1bcu 1bhx 1bmm 1bmn 1c1u 1c1v 1c1w 1c4u 1c4v 1c4y 1c5l 1c5n 1c5o 1ca8 1d3d 1d3p 1d3q 1d3t 1d4p 1d6w 1d9i 1de7 1dit 1dm4 1doj 1dwc 1dwd 1dwe 1dx5 1eb1 1eoj 1eol 1fpc 1fph 1g30 1g32 1g37 1ghv 1ghw 1ghx 1ghy 1gj4 1gj5 1h8d 1h8i 1hag 1hah 1hai 1hao 1hap 1hbt 1hdt 1hgt 1hlt 1hut 1hxe 1hxf 1ihs 1iht 1jmo 1jou 1jwt 1k21 1k22 1kts 1ktt 1lhc 1lhd 1lhe 1lhf 1lhg 1mh0 1mu6 1mu8 1mue 1nm6 1no9 1nrp 1nrr 1nrs 1nt1 1nu7 1nu9 1ny2 1nzq 1o0d 1o2g 1o5g 1ook 1oyt 1p8v 1ppb 1qbv 1qhr 1qj1 1qj6 1qj7 1qur 1rd3 1riw 1sb1 1sfq 1sg8 1sgi 1shh 1sl3 1t4u 1t4v 1ta2 1ta6 1tb6 1tbz 1thp 1thr 1ths 1tmb 1tmt 1tmu 1tom 1tq0 1tq7 1twx 1uma 1uvs 1vr1 1vzq 1w7g 1way 1wbg 1xm1 1xmn 1ycp 1ype 1ypg 1ypj 1ypk 1ypl 1ypm 1z71 1z8i 1z8j 1zgi 1zgv 1zrb 2a0q 2a2x 2afq 2ank 2anm 2b5t 2bdy 2bvr 2bvs 2bxt 2bxu 2c8w 2c8x 2c8y 2c8z 2c90 2c93 2cf8 2cf9 2cn0 2feq 2fes 2gde 2gp9 2h9t 2hgt 2hnt 2hwl 2jh0 2jh5 2jh6 2od3 2pgb 2pgq 2pks 2pw8 2r2m 2thf 2uuf 2uuj 2uuk 2v3h 2v3o 2zc9 2zda 2zdv 2zf0 2zff 2zfp 2zfq 2zfr 2zg0 2zgb 2zgx 2zhe 2zhf 2zhq 2zhw 2zi2 2ziq 2znk 2zo3 3b23 3b9f 3bef 3bei 3bf6 3biu 3biv 3bv9 3c1k 3c27 3d49 3da9 3dd2 3dhk 3dt0 3dux 3e6p 3ee0 3egk 3eq0 3f68 3gic 3gis 3hat 3hkj 3htc 3jz1 3jz2 3k65 3ldx 3lu9 3nxp 3p17 3p6z 3p70 3po1 3qdz 3qgn 3qlp 3qto 3qtv 3qwc 3qx5 3r3g 3rlw 3rly 3rm0 3rm2 3rml 3rmm 3rmn 3rmo 3s7h 3s7k 3sha 3shc 3si3 3si4 3sqe 3sqh 3sv2 3t5f 3tu7 3u69 3u8o 3u8r 3u8t 3u98 3u9a 3utu 3uwj 3vxe 3vxf 4ax9 4ayv 4ayy 4az2 4bah 4bak 4bam 4ban 4bao 4baq 4boh 4ch2 4ch8 4dih 4dii 4dt7 4dy7 4e7r 4h6s 4h6t 4hfp 4htc 4i7y 4loy 4lxb 4lz1 4lz4 4mlf 4nzq 4rkj 4rko 4rn6 4thn 4ud9 4udw 4ue7 4ueh 4ufd 4ufe 4uff 4ufg 4yes 5a2m 5af9 5afy 5afz 5ahg 5cmx 5do4 5e8e 5edm 5ew1 5gds 5gim 5jdu 5jfd 5jzy 5l6n 5lce 5lpd 5mjt 5mls 5mm6 5nhu 6cym 6eo6 6eo7 6eo8 6eo9 6evv 6fjt 6gbw 6gn7 7kme 8kme 4e05 6gwe 6hsx 6px5
16	F7	P08709	Coagulation factor VII		1cvw 1dan 1dva 1fak 1j9c 1jbu 1kli 1klj 1o5d 1qfk 1w0y 1w2k 1w7x 1w8b 1wqv 1wss 1wtg 1wun 1wv7 1ygc 1z6j 2a2q 2aei 2aer 2b7d 2b8o 2bz6 2c4f 2ec9 2f9b 2fir 2flb 2flr 2puq 2zp0 2zwl 2zzu 3ela 3th2 3th3 3th4 4ibl 4ish 4isi 4jyu 4jyv 4jzd 4jze 4jzf 4na9 4ng9 4nga 4x8s 4x8t 4x8u 4x8v 4ylq 4yt6 4yt7 4z6a 4zma 4zxx 4zxy 5i46 5l2y 5l2z 5l30 5pa8 5pa9 5paa 5pab 5pac 5pae 5paf 5pag 5pai 5paj 5pak 5pam 5pan 5pao 5paq 5par 5pas 5pat 5pau 5pav 5paw 5pax 5pay 5pb0 5pb1 5pb2 5pb3 5pb4 5pb5 5pb6 5tqe 5tqf 5tqg 5u6j
17	F9	P00740	Coagulation factor IX		1rfn 2wph 2wpi 2wpj 2wpk 2wpl 2wpm 3kcg 3lc3 3lc5 4yzu 4z0k 4zae 5egm 5jb8 5jb9 5jba 5jbb 5jbc 5tno 5tnt 6mv4 6rfk
18	GZMA	P12544	Granzyme A	CTLA3 HFSP	1op8 1orf
19	GZMB	P10144	Granzyme B	CGL1 CSPB CTLA1 GRB	1iau
20	GZMH	P20718	Granzyme H	CGL2 CTSGL2	3tju 3tjv 3tk9 4gaw
21	GZMK	P49863	Granzyme K	TRYP2	1mza 1mzd
22	GZMM	P51124	Granzyme M	MET1	2zgc 2zgh 2zgj 2zks
23	HGF	P14210	Hepatocyte growth factor	HPTA	1si5 4k3j 4o3t
24	HGFAC	Q04756	Hepatocyte growth factor activator		1ybw 1yc0 2r0l 2wub 2wuc 3k2u
25	HP	P00738	Haptoglobin		4x0l 5hu6
26	HPN	P05981	Serine protease hepsin	TMPRSS1	1o5e 1o5f 1p57 1z8g 3t2n 5ce1
27	KLK1	P06870	Kallikrein-1		1spj
28	KLK10	O43240	Kallikrein-10	NES1 PRSSL1	5lpe 5lpf
29	KLK2	P20151	Kallikrein-2		4nfe 4nff
30	KLK3	P07288	Prostate-specific antigen	APS	2zch
31	KLK4	Q9Y5K2	Kallikrein-4	EMSP1 PRSS17 PSTS	2bdg 2bdh 2bdi 4k1e 4k8y 4kel 4kga 6o21 6kbr 6nvb
32	KLK5	Q9Y337	Kallikrein-5	SCTE	2psx 2psy 6qfe
33	KLK6	Q92876	Kallikrein-6	PRSS18 PRSS9	1gvl 1l2e 1lo6 3vfe 4d8n 5nx1 5nx3 6qff 6qfg 6qfh 6qh9 6qha 6qhb 6qhc 6skb 6skc 6skd
34	KLK7	P49862	Kallikrein-7	PRSS6 SCCE	2qxg 2qxh 2qxi 2qxj 3bsq 5fah 5y9l 5yjk
35	KLK8	O60259	Kallikrein-8	NRPN PRSS19 TADG14	5ms3 5ms4
36	KLKB1	P03952	Plasma kallikrein	KLK3	2anw 2any 4ogx 4ogy 5f8t 5f8x 5f8z 5tjx 6i44 6o1g 6o1s
37	MASP1	P48740	Mannan-binding lectin serine protease 1	CRARF CRARF1 PRSS5	3gov 4igd
38	MASP2	O00187	Mannan-binding lectin serine protease 2		1q3x 1zjk 3tvj
39	MST1	P26927	Hepatocyte growth factor-like protein	D3F15S2 DNF15S2 HGFL	2asu 4qt8
40	PLAT	P00750	Tissue-type plasminogen activator		1a5h 1rtf
41	PLAU	P00749	Urokinase-type plasminogen activator		1c5w 1c5x 1c5y 1c5z 1ejn 1f5k 1f5l 1f92 1fv9 1gi7 1gi8 1gi9 1gj7 1gj8 1gj9 1gja 1gjb 1gjc 1gjd 1lmw 1o3p 1o5a 1o5b 1o5c 1owd 1owe 1owh 1owi 1owk 1sc8 1sqa 1sqo 1sqt 1u6q 1vj9 1vja 1w0z 1w10 1w11 1w12 1w13 1w14 2nwn 2o8t 2o8u 2o8w 2r2w 2vin 2vio 2vip 2viq 2viv 2viw 2vnt 3ig6 3kgp 3khv 3kid 3m61 3mhw 3mwi 3ox7 3oy5 3oy6 3pb1 3qn7 4dva 4dw2 4fu7 4fu8 4fu9 4fub 4fuc 4fud 4fue 4fuf 4fug 4fuh 4fui 4fuj 4gly 4h42 4jk5 4jk6 4mnv 4mnw 4mnx 4mny 4os1 4os2 4os4 4os5 4os6 4os7 4x0w 4x1n 4x1p 4x1q 4x1r 4x1s 4xsk 4zhl 4zhm 4zkn 4zko 4zkr 4zks 5hgg 5wxf 5wxo 5wxp 5wxq 5wxr 5wxs 5wxt 5xg4 5yc6 5yc7 5z1c 5za7 5za8 5za9 5zae 5zaf 5zag 5zah 5zaj 5zc5 6nmb 6ag2 6ag3 6ag7 6ag9
42	PLG	P00747	Plasminogen		1bml 1bui 1ddj 1l4d 1l4z 1qrz 1rjx 3uir 4dur 5ugd 5ugg 6d3x 6d3y 6d3z 6d40
43	PROC	P04070	Vitamin K-dependent protein C		1aut 3f6u
44	PROZ	P22891	Vitamin K-dependent protein Z		3f1s
45	PRSS1	P07477	Trypsin-1	TRP1 TRY1 TRYP1	1trn 2ra3 4wwy 4wxv
46	PRSS3	P35030	Trypsin-3	PRSS4 TRY3 TRY4	1h4w 2r9p 3l33 3l3t 3p92 3p95 4dg4 4u30 4u32 5c67 5jbt 5tp0 6bx8 6gfi 6har
47	PRSS57	Q6UWY2	Serine protease 57	PRSSL1	4q7x 4q7y 4q7z
48	PRSS8	Q16651	Prostasin		3dfj 3dfl 3e0n 3e0p 3e1x 3fvf 3gyl 3gym 3e16
49	PRTN3	P24158	Myeloblastin	MBN	1fuj
50	ST14	Q9Y5Y6	Suppressor of tumorigenicity 14 protein	PRSS14 SNC19 TADG15	1eaw 1eax 2gv6 2gv7 3bn9 3ncl 3nps 3p8f 3p8g 3so3 4is5 4isl 4isn 4iso 4jyt 4jz1 4jzi 4o97 4o9v 4r0i 5lyo 6n4t
51	TMPRSS11E	Q9UL52	Transmembrane protease serine 11E	DESC1 TMPRSS11E2	2oq5
52	TMPRSS15	P98073	Enteropeptidase	ENTK PRSS7	4dgj
53	TPSB2	P20231	Tryptase beta-2	TPS2	1a0l 2bm2 2fpz 2fs8 2fs9 2fww 2fxr 2gdd 2za5 2zeb 2zec 3v7t 4a6l 4mpu 4mpv 4mpw 4mpx 4mqa 5f03 5wi6 6o1f