The Ligandable Human Proteome

Protein kinase domain

Index	Gene Name	Protein Name	Drugs	PDB Code
1	AAK1	AP2-associated protein kinase 1	Nintedanib	5te0
2	MELK	Maternal embryonic leucine zipper kinase	Nintedanib	5maf
3	PIM1	Serine/threonine-protein kinase pim-1	Thioridazine	4iaa
4	MK11	Mitogen-activated protein kinase 11	Nilotinib	3gp0
5	MP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Cobimetinib	4an2, 4lmn
6	PMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Bosutinib,Dasatinib	5vcy, 5vcv
7	WEE1	Wee1-like protein kinase	Bosutinib	5vc3
8	STK24	Serine/threonine-protein kinase 24	Bosutinib,Dasatinib,Sunitinib	4qmn, 4qms, 4qmz
9	STK10	Serine/threonine-protein kinase 10	Bosutinib,Dasatinib	5ajq, 5owr
10	M4K1	Mitogen-activated protein kinase kinase kinase kinase 1	Sunitinib	6ng0, 6nfz
11	CDK6	Cyclin-dependent kinase 6	Abemaciclib,Palbociclib,Ribociclib	5l2s, 5l2i, 2euf, 5l2t
12	MK14	Mitogen-activated protein kinase 14	Dasatinib,Sorafenib,Imatinib	3lfa, 3heg, 3gcs, 3hec
13	CDK8	Cyclin-dependent kinase 8	Sorafenib	3rgf
14	CDK2	Cyclin-dependent kinase 2	Sunitinib	3ti1
15	PHKG2	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Sunitinib	2y7j
16	PAK6	Serine/threonine-protein kinase PAK 6	Sunitinib	4ks8
17	ARBK1	Beta-adrenergic receptor kinase 1	Paroxetine	3v5w
18	PKN1	Serine/threonine-protein kinase N1	Tofacitinib	4oti
19	RET	Proto-oncogene tyrosine-protein kinase receptor Ret	Vandetanib,Nintedanib	2ivu, 6nec
20	VGFR2	Vascular endothelial growth factor receptor 2	Nintedanib,Sorafenib,Sunitinib	3c7q, 3wze, 4asd, 4agd
21	ABL1	Tyrosine-protein kinase ABL1	Imatinib,Nilotinib,Bosutinib,Ponatinib,Dasatinib	6npe, 6npv, 6npu, 6hd4, 3cs9, 5mo4, 3ue4, 3ik3, 3oxz, 2gqg, 4xey, 3ms9, 1opj, 1iep, 3k5v, 3pyy, 2hyy, 6hd6, 3mss
22	BRAF	Serine/threonine-protein kinase B-raf	Dabrafenib,Vemurafenib,Sorafenib	5hie, 4xv2, 5csw, 4rzv, 3og7, 5hi2, 1uwh
23	EGFR	Epidermal growth factor receptor	Lapatinib,Dacomitinib,Erlotinib,Osimertinib,Ibrutinib,Afatinib	1xkk, 4i23, 4i24, 1m17, 4hjo, 4zau, 5yu9, 4g5j
24	ERBB4	Receptor tyrosine-protein kinase erbB-4	Lapatinib	3bbt
25	EPHA2	Ephrin type-A receptor 2	Bosutinib,Dasatinib	5i9x, 5i9y
26	SRC	Proto-oncogene tyrosine-protein kinase Src	Bosutinib,Dasatinib,Imatinib	4mxz, 4mxx, 4mxy, 4mxo, 3qlg, 3g5d, 3oez, 2oiq
27	ERBB3	Receptor tyrosine-protein kinase erbB-3	Bosutinib	6op9
28	ALK	ALK tyrosine kinase receptor	Ceritinib,Crizotinib,Lorlatinib	4mkc, 2yfx, 4anq, 4ans, 2xp2, 5aab, 5aac, 5aaa, 5a9u, 5aa8, 5aa9, 4cli, 4clj
29	DDR1	Epithelial discoidin domain-containing receptor 1	Dasatinib,Imatinib	6bsd, 5bvw, 4bkj
30	FGFR1	Fibroblast growth factor receptor 1	Ponatinib	4v01, 4v04
31	FGFR4	Fibroblast growth factor receptor 4	Ponatinib	4uxq, 4qrc, 4tyj
32	IRAK4	Interleukin-1 receptor-associated kinase 4	Ponatinib	6eg9
33	KIT	Mast/stem cell growth factor receptor Kit	Ponatinib,Imatinib,Sunitinib	4u0i, 1t46, 3g0e, 3g0f
34	RIPK2	Receptor-interacting serine/threonine-protein kinase 2	Ponatinib	4c8b
35	M3K20	Mitogen-activated protein kinase kinase kinase 20	Vemurafenib	5hes
36	PTK6	Protein-tyrosine kinase 6	Dasatinib	5h2u
37	BMX	Cytoplasmic tyrosine-protein kinase BMX	Dasatinib	3sxr
38	BTK	Tyrosine-protein kinase BTK	Dasatinib,Ibrutinib	3oct, 3k54, 5p9i
39	EPHB4	Ephrin type-B receptor 4	Dasatinib	6fnm
40	EPHA4	Ephrin type-A receptor 4	Dasatinib	2y6o
41	ABL2	Tyrosine-protein kinase ABL2	Dasatinib	4xli
42	LYN	Tyrosine-protein kinase Lyn	Dasatinib	2zva
43	JAK1	Tyrosine-protein kinase JAK1	Tofacitinib	3eyg
44	TYK2	Non-receptor tyrosine-protein kinase TYK2	Tofacitinib	3lxn
45	JAK2	Tyrosine-protein kinase JAK2	Tofacitinib	3fup
46	JAK3	Tyrosine-protein kinase JAK3	Tofacitinib	3lxk
47	CSF1R	Macrophage colony-stimulating factor 1 receptor	Imatinib	4r7i
48	KSYK	Tyrosine-protein kinase SYK	Imatinib	1xbb
49	LCK	Tyrosine-protein kinase Lck	Imatinib	2pl0
50	ROS1	Proto-oncogene tyrosine-protein kinase ROS	Crizotinib,Lorlatinib	3zbf, 4uxl
51	MET	Hepatocyte growth factor receptor	Crizotinib	2wgj
52	ITK	Tyrosine-protein kinase ITK/TSK	Sunitinib	3miy