| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | THYROID | -1.572 | 3 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | CERVIX | -1.582 | 3 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | PLEURA | -1.333 | 7 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | ENDOMETRIUM | -1.475 | 16 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | LIVER | -1.486 | 16 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | GANGLIA | -1.529 | 18 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | KIDNEY | -1.409 | 20 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | STOMACH | -1.482 | 20 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | BONE | -1.45 | 23 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | OESOPHAGUS | -1.576 | 24 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | INTESTINE | -1.423 | 25 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | PANCREAS | -1.471 | 26 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | BREAST | -1.431 | 28 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | SOFT_TISSUE | -1.42 | 31 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | OVARY | -1.456 | 36 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | SKIN | -1.469 | 36 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | SYSTEM | -1.441 | 44 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | TRACT | -1.516 | 53 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.521 | 59 |
| 1 | FBL | rRNA 2'-O-methyltransferase fibrillarin | LUNG | -1.446 | 73 |