The Ligandable Human Proteome

Protein kinase domain

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	NRBP1	Nuclear receptor-binding protein	PLEURA	-1.079	7
1	NRBP1	Nuclear receptor-binding protein	GANGLIA	-1.009	18
1	NRBP1	Nuclear receptor-binding protein	STOMACH	-1.095	20
1	NRBP1	Nuclear receptor-binding protein	BONE	-1.018	23
1	NRBP1	Nuclear receptor-binding protein	OESOPHAGUS	-1.007	24
1	NRBP1	Nuclear receptor-binding protein	INTESTINE	-1.014	25
1	NRBP1	Nuclear receptor-binding protein	PANCREAS	-1.18	26
1	NRBP1	Nuclear receptor-binding protein	SKIN	-1.008	36
1	NRBP1	Nuclear receptor-binding protein	TRACT	-1.025	53
1	NRBP1	Nuclear receptor-binding protein	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.082	58
1	NRBP1	Nuclear receptor-binding protein	LUNG	-1.039	73
2	WNK1	Serine/threonine-protein kinase WNK1	PLEURA	-1.01	7
2	WNK1	Serine/threonine-protein kinase WNK1	LIVER	-1.111	16
2	WNK1	Serine/threonine-protein kinase WNK1	STOMACH	-1.282	20
2	WNK1	Serine/threonine-protein kinase WNK1	KIDNEY	-1.335	20
2	WNK1	Serine/threonine-protein kinase WNK1	OESOPHAGUS	-1.236	24
2	WNK1	Serine/threonine-protein kinase WNK1	INTESTINE	-1.193	25
2	WNK1	Serine/threonine-protein kinase WNK1	PANCREAS	-1.352	26
2	WNK1	Serine/threonine-protein kinase WNK1	BREAST	-1.129	28
2	WNK1	Serine/threonine-protein kinase WNK1	SKIN	-1.258	36
2	WNK1	Serine/threonine-protein kinase WNK1	SYSTEM	-1.001	44
2	WNK1	Serine/threonine-protein kinase WNK1	TRACT	-1.236	53
2	WNK1	Serine/threonine-protein kinase WNK1	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.465	58
2	WNK1	Serine/threonine-protein kinase WNK1	LUNG	-1.185	73
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PLEURA	-1.047	7
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	LIVER	-1.073	16
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	ENDOMETRIUM	-1.28	16
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	GANGLIA	-1.156	18
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	KIDNEY	-1.095	20
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	STOMACH	-1.154	20
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	BONE	-1.005	23
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	OESOPHAGUS	-1.088	24
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	INTESTINE	-1.106	25
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PANCREAS	-1.215	26
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	BREAST	-1.136	28
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	SOFT_TISSUE	-1.032	31
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	OVARY	-1.064	36
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	SYSTEM	-1.061	44
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	TRACT	-1.108	53
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.121	58
3	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	LUNG	-1.103	73
4	MASTL	Serine/threonine-protein kinase greatwall	THYROID	-1.596	3
4	MASTL	Serine/threonine-protein kinase greatwall	CERVIX	-1.74	3
4	MASTL	Serine/threonine-protein kinase greatwall	PLEURA	-1.806	7
4	MASTL	Serine/threonine-protein kinase greatwall	LIVER	-1.589	16
4	MASTL	Serine/threonine-protein kinase greatwall	ENDOMETRIUM	-1.609	16
4	MASTL	Serine/threonine-protein kinase greatwall	GANGLIA	-1.828	18
4	MASTL	Serine/threonine-protein kinase greatwall	KIDNEY	-1.673	20
4	MASTL	Serine/threonine-protein kinase greatwall	STOMACH	-1.748	20
4	MASTL	Serine/threonine-protein kinase greatwall	BONE	-1.816	23
4	MASTL	Serine/threonine-protein kinase greatwall	OESOPHAGUS	-1.841	24
4	MASTL	Serine/threonine-protein kinase greatwall	INTESTINE	-1.801	25
4	MASTL	Serine/threonine-protein kinase greatwall	PANCREAS	-1.753	26
4	MASTL	Serine/threonine-protein kinase greatwall	BREAST	-1.759	28
4	MASTL	Serine/threonine-protein kinase greatwall	SOFT_TISSUE	-1.65	31
4	MASTL	Serine/threonine-protein kinase greatwall	OVARY	-1.662	36
4	MASTL	Serine/threonine-protein kinase greatwall	SKIN	-1.81	36
4	MASTL	Serine/threonine-protein kinase greatwall	SYSTEM	-1.777	44
4	MASTL	Serine/threonine-protein kinase greatwall	TRACT	-1.814	53
4	MASTL	Serine/threonine-protein kinase greatwall	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.923	58
4	MASTL	Serine/threonine-protein kinase greatwall	LUNG	-1.674	73
5	AURKB	Aurora kinase B	CERVIX	-1.549	3
5	AURKB	Aurora kinase B	THYROID	-1.555	3
5	AURKB	Aurora kinase B	PLEURA	-1.345	7
5	AURKB	Aurora kinase B	ENDOMETRIUM	-1.33	16
5	AURKB	Aurora kinase B	LIVER	-1.418	16
5	AURKB	Aurora kinase B	GANGLIA	-1.523	18
5	AURKB	Aurora kinase B	STOMACH	-1.412	20
5	AURKB	Aurora kinase B	KIDNEY	-1.423	20
5	AURKB	Aurora kinase B	BONE	-1.433	23
5	AURKB	Aurora kinase B	OESOPHAGUS	-1.387	24
5	AURKB	Aurora kinase B	INTESTINE	-1.339	25
5	AURKB	Aurora kinase B	PANCREAS	-1.4	26
5	AURKB	Aurora kinase B	BREAST	-1.413	28
5	AURKB	Aurora kinase B	SOFT_TISSUE	-1.414	31
5	AURKB	Aurora kinase B	SKIN	-1.442	36
5	AURKB	Aurora kinase B	OVARY	-1.452	36
5	AURKB	Aurora kinase B	SYSTEM	-1.502	44
5	AURKB	Aurora kinase B	TRACT	-1.316	53
5	AURKB	Aurora kinase B	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.522	59
5	AURKB	Aurora kinase B	LUNG	-1.396	73
6	PLK1	Serine/threonine-protein kinase PLK1	CERVIX	-1.569	3
6	PLK1	Serine/threonine-protein kinase PLK1	THYROID	-1.572	3
6	PLK1	Serine/threonine-protein kinase PLK1	PLEURA	-1.474	7
6	PLK1	Serine/threonine-protein kinase PLK1	ENDOMETRIUM	-1.711	16
6	PLK1	Serine/threonine-protein kinase PLK1	LIVER	-1.722	16
6	PLK1	Serine/threonine-protein kinase PLK1	GANGLIA	-1.758	18
6	PLK1	Serine/threonine-protein kinase PLK1	KIDNEY	-1.46	20
6	PLK1	Serine/threonine-protein kinase PLK1	STOMACH	-1.729	20
6	PLK1	Serine/threonine-protein kinase PLK1	BONE	-1.638	23
6	PLK1	Serine/threonine-protein kinase PLK1	OESOPHAGUS	-1.65	24
6	PLK1	Serine/threonine-protein kinase PLK1	INTESTINE	-1.6	25
6	PLK1	Serine/threonine-protein kinase PLK1	PANCREAS	-1.6	26
6	PLK1	Serine/threonine-protein kinase PLK1	BREAST	-1.631	28
6	PLK1	Serine/threonine-protein kinase PLK1	SOFT_TISSUE	-1.608	31
6	PLK1	Serine/threonine-protein kinase PLK1	OVARY	-1.581	36
6	PLK1	Serine/threonine-protein kinase PLK1	SKIN	-1.644	36
6	PLK1	Serine/threonine-protein kinase PLK1	SYSTEM	-1.576	44
6	PLK1	Serine/threonine-protein kinase PLK1	TRACT	-1.641	53
6	PLK1	Serine/threonine-protein kinase PLK1	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.833	58
6	PLK1	Serine/threonine-protein kinase PLK1	LUNG	-1.65	73
7	CDK9	Cyclin-dependent kinase 9	THYROID	-1.213	3
7	CDK9	Cyclin-dependent kinase 9	CERVIX	-1.348	3
7	CDK9	Cyclin-dependent kinase 9	PLEURA	-1.113	7
7	CDK9	Cyclin-dependent kinase 9	LIVER	-1.279	16
7	CDK9	Cyclin-dependent kinase 9	ENDOMETRIUM	-1.294	16
7	CDK9	Cyclin-dependent kinase 9	GANGLIA	-1.251	18
7	CDK9	Cyclin-dependent kinase 9	STOMACH	-1.225	20
7	CDK9	Cyclin-dependent kinase 9	KIDNEY	-1.316	20
7	CDK9	Cyclin-dependent kinase 9	BONE	-1.28	23
7	CDK9	Cyclin-dependent kinase 9	OESOPHAGUS	-1.214	24
7	CDK9	Cyclin-dependent kinase 9	INTESTINE	-1.234	25
7	CDK9	Cyclin-dependent kinase 9	PANCREAS	-1.274	26
7	CDK9	Cyclin-dependent kinase 9	BREAST	-1.268	28
7	CDK9	Cyclin-dependent kinase 9	SOFT_TISSUE	-1.235	31
7	CDK9	Cyclin-dependent kinase 9	SKIN	-1.267	36
7	CDK9	Cyclin-dependent kinase 9	OVARY	-1.324	36
7	CDK9	Cyclin-dependent kinase 9	SYSTEM	-1.315	44
7	CDK9	Cyclin-dependent kinase 9	TRACT	-1.203	53
7	CDK9	Cyclin-dependent kinase 9	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.371	59
7	CDK9	Cyclin-dependent kinase 9	LUNG	-1.291	73
8	CDK7	Cyclin-dependent kinase 7	CERVIX	-1.603	3
8	CDK7	Cyclin-dependent kinase 7	THYROID	-1.69	3
8	CDK7	Cyclin-dependent kinase 7	PLEURA	-1.663	7
8	CDK7	Cyclin-dependent kinase 7	LIVER	-1.709	16
8	CDK7	Cyclin-dependent kinase 7	ENDOMETRIUM	-1.807	16
8	CDK7	Cyclin-dependent kinase 7	GANGLIA	-1.799	18
8	CDK7	Cyclin-dependent kinase 7	STOMACH	-1.706	20
8	CDK7	Cyclin-dependent kinase 7	KIDNEY	-1.746	20
8	CDK7	Cyclin-dependent kinase 7	BONE	-1.835	23
8	CDK7	Cyclin-dependent kinase 7	OESOPHAGUS	-1.84	24
8	CDK7	Cyclin-dependent kinase 7	INTESTINE	-1.71	25
8	CDK7	Cyclin-dependent kinase 7	PANCREAS	-1.728	26
8	CDK7	Cyclin-dependent kinase 7	BREAST	-1.734	28
8	CDK7	Cyclin-dependent kinase 7	SOFT_TISSUE	-1.665	31
8	CDK7	Cyclin-dependent kinase 7	OVARY	-1.744	36
8	CDK7	Cyclin-dependent kinase 7	SKIN	-1.818	36
8	CDK7	Cyclin-dependent kinase 7	SYSTEM	-1.743	44
8	CDK7	Cyclin-dependent kinase 7	TRACT	-1.797	53
8	CDK7	Cyclin-dependent kinase 7	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.949	59
8	CDK7	Cyclin-dependent kinase 7	LUNG	-1.76	73
9	WEE1	Wee1-like protein kinase	THYROID	-1.868	3
9	WEE1	Wee1-like protein kinase	CERVIX	-1.962	3
9	WEE1	Wee1-like protein kinase	PLEURA	-1.823	7
9	WEE1	Wee1-like protein kinase	ENDOMETRIUM	-1.811	16
9	WEE1	Wee1-like protein kinase	LIVER	-1.89	16
9	WEE1	Wee1-like protein kinase	GANGLIA	-2.207	18
9	WEE1	Wee1-like protein kinase	KIDNEY	-1.952	20
9	WEE1	Wee1-like protein kinase	STOMACH	-1.958	20
9	WEE1	Wee1-like protein kinase	BONE	-1.993	23
9	WEE1	Wee1-like protein kinase	OESOPHAGUS	-1.868	24
9	WEE1	Wee1-like protein kinase	INTESTINE	-1.803	25
9	WEE1	Wee1-like protein kinase	PANCREAS	-1.889	26
9	WEE1	Wee1-like protein kinase	BREAST	-2.033	28
9	WEE1	Wee1-like protein kinase	SOFT_TISSUE	-1.919	31
9	WEE1	Wee1-like protein kinase	SKIN	-1.995	36
9	WEE1	Wee1-like protein kinase	OVARY	-2.01	36
9	WEE1	Wee1-like protein kinase	SYSTEM	-1.9	44
9	WEE1	Wee1-like protein kinase	TRACT	-1.905	53
9	WEE1	Wee1-like protein kinase	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-2.031	58
9	WEE1	Wee1-like protein kinase	LUNG	-1.942	73
10	CDK1	Cyclin-dependent kinase 1	CERVIX	-1.793	3
10	CDK1	Cyclin-dependent kinase 1	THYROID	-2.017	3
10	CDK1	Cyclin-dependent kinase 1	PLEURA	-1.752	7
10	CDK1	Cyclin-dependent kinase 1	ENDOMETRIUM	-1.705	16
10	CDK1	Cyclin-dependent kinase 1	LIVER	-1.728	16
10	CDK1	Cyclin-dependent kinase 1	GANGLIA	-1.812	18
10	CDK1	Cyclin-dependent kinase 1	KIDNEY	-1.68	20
10	CDK1	Cyclin-dependent kinase 1	STOMACH	-1.745	20
10	CDK1	Cyclin-dependent kinase 1	BONE	-1.704	23
10	CDK1	Cyclin-dependent kinase 1	OESOPHAGUS	-1.812	24
10	CDK1	Cyclin-dependent kinase 1	INTESTINE	-1.715	25
10	CDK1	Cyclin-dependent kinase 1	PANCREAS	-1.758	26
10	CDK1	Cyclin-dependent kinase 1	BREAST	-1.761	28
10	CDK1	Cyclin-dependent kinase 1	SOFT_TISSUE	-1.724	31
10	CDK1	Cyclin-dependent kinase 1	SKIN	-1.712	36
10	CDK1	Cyclin-dependent kinase 1	OVARY	-1.727	36
10	CDK1	Cyclin-dependent kinase 1	SYSTEM	-1.675	44
10	CDK1	Cyclin-dependent kinase 1	TRACT	-1.674	53
10	CDK1	Cyclin-dependent kinase 1	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.855	59
10	CDK1	Cyclin-dependent kinase 1	LUNG	-1.759	73
11	AURKA	Aurora kinase A	CERVIX	-1.015	3
11	AURKA	Aurora kinase A	THYROID	-1.352	3
11	AURKA	Aurora kinase A	PLEURA	-1.155	7
11	AURKA	Aurora kinase A	LIVER	-1.086	16
11	AURKA	Aurora kinase A	ENDOMETRIUM	-1.189	16
11	AURKA	Aurora kinase A	GANGLIA	-1.248	18
11	AURKA	Aurora kinase A	STOMACH	-1.127	20
11	AURKA	Aurora kinase A	KIDNEY	-1.167	20
11	AURKA	Aurora kinase A	BONE	-1.245	23
11	AURKA	Aurora kinase A	OESOPHAGUS	-1.184	24
11	AURKA	Aurora kinase A	INTESTINE	-1.15	25
11	AURKA	Aurora kinase A	PANCREAS	-1.111	26
11	AURKA	Aurora kinase A	BREAST	-1.239	28
11	AURKA	Aurora kinase A	SOFT_TISSUE	-1.321	31
11	AURKA	Aurora kinase A	SKIN	-1.155	36
11	AURKA	Aurora kinase A	OVARY	-1.202	36
11	AURKA	Aurora kinase A	SYSTEM	-1.224	44
11	AURKA	Aurora kinase A	TRACT	-1.103	53
11	AURKA	Aurora kinase A	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.233	59
11	AURKA	Aurora kinase A	LUNG	-1.254	73
12	CHEK1	Serine/threonine-protein kinase Chk1	THYROID	-1.359	3
12	CHEK1	Serine/threonine-protein kinase Chk1	CERVIX	-1.369	3
12	CHEK1	Serine/threonine-protein kinase Chk1	PLEURA	-1.478	7
12	CHEK1	Serine/threonine-protein kinase Chk1	ENDOMETRIUM	-1.54	16
12	CHEK1	Serine/threonine-protein kinase Chk1	LIVER	-1.565	16
12	CHEK1	Serine/threonine-protein kinase Chk1	GANGLIA	-1.733	18
12	CHEK1	Serine/threonine-protein kinase Chk1	STOMACH	-1.46	20
12	CHEK1	Serine/threonine-protein kinase Chk1	KIDNEY	-1.493	20
12	CHEK1	Serine/threonine-protein kinase Chk1	BONE	-1.596	23
12	CHEK1	Serine/threonine-protein kinase Chk1	OESOPHAGUS	-1.599	24
12	CHEK1	Serine/threonine-protein kinase Chk1	INTESTINE	-1.481	25
12	CHEK1	Serine/threonine-protein kinase Chk1	PANCREAS	-1.472	26
12	CHEK1	Serine/threonine-protein kinase Chk1	BREAST	-1.697	28
12	CHEK1	Serine/threonine-protein kinase Chk1	SOFT_TISSUE	-1.509	31
12	CHEK1	Serine/threonine-protein kinase Chk1	OVARY	-1.549	36
12	CHEK1	Serine/threonine-protein kinase Chk1	SKIN	-1.659	36
12	CHEK1	Serine/threonine-protein kinase Chk1	SYSTEM	-1.482	44
12	CHEK1	Serine/threonine-protein kinase Chk1	TRACT	-1.507	53
12	CHEK1	Serine/threonine-protein kinase Chk1	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.682	59
12	CHEK1	Serine/threonine-protein kinase Chk1	LUNG	-1.489	73
13	PLK4	Serine/threonine-protein kinase PLK4	THYROID	-1.106	3
13	PLK4	Serine/threonine-protein kinase PLK4	PLEURA	-1.105	7
13	PLK4	Serine/threonine-protein kinase PLK4	LIVER	-1.096	16
13	PLK4	Serine/threonine-protein kinase PLK4	GANGLIA	-1.116	18
13	PLK4	Serine/threonine-protein kinase PLK4	STOMACH	-1.015	20
13	PLK4	Serine/threonine-protein kinase PLK4	KIDNEY	-1.076	20
13	PLK4	Serine/threonine-protein kinase PLK4	BONE	-1.151	23
13	PLK4	Serine/threonine-protein kinase PLK4	OESOPHAGUS	-1.12	24
13	PLK4	Serine/threonine-protein kinase PLK4	INTESTINE	-1.024	25
13	PLK4	Serine/threonine-protein kinase PLK4	PANCREAS	-1.074	26
13	PLK4	Serine/threonine-protein kinase PLK4	SOFT_TISSUE	-1.097	31
13	PLK4	Serine/threonine-protein kinase PLK4	SKIN	-1.045	36
13	PLK4	Serine/threonine-protein kinase PLK4	OVARY	-1.089	36
13	PLK4	Serine/threonine-protein kinase PLK4	SYSTEM	-1.014	44
13	PLK4	Serine/threonine-protein kinase PLK4	TRACT	-1.113	53
13	PLK4	Serine/threonine-protein kinase PLK4	LUNG	-1.031	73
14	CDC7	Cell division cycle 7-related protein kinase	THYROID	-1.445	3
14	CDC7	Cell division cycle 7-related protein kinase	CERVIX	-1.645	3
14	CDC7	Cell division cycle 7-related protein kinase	PLEURA	-1.401	7
14	CDC7	Cell division cycle 7-related protein kinase	LIVER	-1.47	16
14	CDC7	Cell division cycle 7-related protein kinase	ENDOMETRIUM	-1.522	16
14	CDC7	Cell division cycle 7-related protein kinase	GANGLIA	-1.531	18
14	CDC7	Cell division cycle 7-related protein kinase	KIDNEY	-1.413	20
14	CDC7	Cell division cycle 7-related protein kinase	STOMACH	-1.498	20
14	CDC7	Cell division cycle 7-related protein kinase	BONE	-1.489	23
14	CDC7	Cell division cycle 7-related protein kinase	OESOPHAGUS	-1.442	24
14	CDC7	Cell division cycle 7-related protein kinase	INTESTINE	-1.558	25
14	CDC7	Cell division cycle 7-related protein kinase	PANCREAS	-1.506	26
14	CDC7	Cell division cycle 7-related protein kinase	BREAST	-1.458	28
14	CDC7	Cell division cycle 7-related protein kinase	SOFT_TISSUE	-1.5	31
14	CDC7	Cell division cycle 7-related protein kinase	SKIN	-1.482	36
14	CDC7	Cell division cycle 7-related protein kinase	OVARY	-1.49	36
14	CDC7	Cell division cycle 7-related protein kinase	SYSTEM	-1.446	44
14	CDC7	Cell division cycle 7-related protein kinase	TRACT	-1.428	53
14	CDC7	Cell division cycle 7-related protein kinase	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.501	59
14	CDC7	Cell division cycle 7-related protein kinase	LUNG	-1.483	73