| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | CERVIX | -1.112 | 3 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | ENDOMETRIUM | -1.02 | 16 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | GANGLIA | -1.007 | 18 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | KIDNEY | -1.082 | 20 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | STOMACH | -1.101 | 20 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | OESOPHAGUS | -1.091 | 24 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | INTESTINE | -1.144 | 25 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | PANCREAS | -1.208 | 26 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | BREAST | -1.17 | 28 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | SOFT_TISSUE | -1.097 | 31 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | OVARY | -1.111 | 36 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | SKIN | -1.12 | 36 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | TRACT | -1.025 | 53 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.252 | 58 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | LUNG | -1.119 | 73 |