| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Bone | -1.63 | 12 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Haematopoietic and Lymphoid | -1.606 | 14 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Head and Neck | -1.462 | 34 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Skin | -1.445 | 4 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Esophagus | -1.402 | 26 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Stomach | -1.397 | 14 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Peripheral Nervous System | -1.371 | 17 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Large Intestine | -1.363 | 30 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Prostate | -1.251 | 3 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Ovary | -1.251 | 31 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Lung | -1.21 | 42 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Endometrium | -1.173 | 8 |
| 1 | TRRAP | Transformation/transcription domain-associated protein | Kidney | -1.168 | 3 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | Skin | -1.28 | 4 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | Large Intestine | -1.137 | 30 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | Esophagus | -1.093 | 26 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | Stomach | -1.079 | 14 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | Head and Neck | -1.042 | 34 |
| 2 | SMG1 | Serine/threonine-protein kinase SMG1 | Endometrium | -1.023 | 8 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Bone | -2.552 | 12 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Kidney | -2.518 | 3 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Head and Neck | -2.234 | 34 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Skin | -2.02 | 4 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Esophagus | -2.009 | 26 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Peripheral Nervous System | -1.954 | 17 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Central Nervous System | -1.713 | 33 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Haematopoietic and Lymphoid | -1.712 | 14 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Pancreas | -1.704 | 23 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Prostate | -1.681 | 3 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Ovary | -1.627 | 31 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Endometrium | -1.504 | 8 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Breast | -1.466 | 25 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Lung | -1.295 | 42 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Large Intestine | -1.291 | 30 |
| 3 | ATR | Serine/threonine-protein kinase ATR | Stomach | -1.201 | 14 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Skin | -2.386 | 4 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Bone | -1.692 | 12 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Head and Neck | -1.538 | 34 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Esophagus | -1.482 | 26 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Central Nervous System | -1.448 | 33 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Kidney | -1.382 | 3 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Haematopoietic and Lymphoid | -1.272 | 14 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Prostate | -1.223 | 3 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Stomach | -1.12 | 14 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Large Intestine | -1.1 | 30 |
| 4 | MTOR | Serine/threonine-protein kinase mTOR | Lung | -1.085 | 42 |