| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | SUPT16H | FACT complex subunit SPT16 | Kidney | -3.508 | 3 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Skin | -3.495 | 4 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Head and Neck | -3.287 | 34 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Haematopoietic and Lymphoid | -3.082 | 14 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Bone | -3.059 | 12 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Large Intestine | -2.989 | 30 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Central Nervous System | -2.923 | 33 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Esophagus | -2.764 | 26 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Endometrium | -2.616 | 8 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Pancreas | -2.53 | 23 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Stomach | -2.411 | 14 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Ovary | -2.38 | 31 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Lung | -2.296 | 42 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Prostate | -2.254 | 3 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Breast | -2.136 | 25 |
| 1 | SUPT16H | FACT complex subunit SPT16 | Peripheral Nervous System | -1.999 | 17 |
| 2 | METAP1 | Methionine aminopeptidase 1 | Bone | -1.224 | 12 |
| 2 | METAP1 | Methionine aminopeptidase 1 | Esophagus | -1.135 | 26 |
| 2 | METAP1 | Methionine aminopeptidase 1 | Head and Neck | -1.033 | 34 |