The Ligandable Human Proteome

Proteasome, subunit alpha/beta

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	PSMB7	Proteasome subunit beta type-7	Skin	-3.645	4
1	PSMB7	Proteasome subunit beta type-7	Kidney	-3.353	3
1	PSMB7	Proteasome subunit beta type-7	Head and Neck	-3.198	34
1	PSMB7	Proteasome subunit beta type-7	Esophagus	-3.085	26
1	PSMB7	Proteasome subunit beta type-7	Lung	-2.694	42
1	PSMB7	Proteasome subunit beta type-7	Pancreas	-2.692	23
1	PSMB7	Proteasome subunit beta type-7	Central Nervous System	-2.647	33
1	PSMB7	Proteasome subunit beta type-7	Large Intestine	-2.458	30
1	PSMB7	Proteasome subunit beta type-7	Bone	-2.445	12
1	PSMB7	Proteasome subunit beta type-7	Ovary	-2.308	31
1	PSMB7	Proteasome subunit beta type-7	Stomach	-2.223	14
1	PSMB7	Proteasome subunit beta type-7	Peripheral Nervous System	-2.079	17
1	PSMB7	Proteasome subunit beta type-7	Breast	-2.041	25
1	PSMB7	Proteasome subunit beta type-7	Prostate	-1.899	3
1	PSMB7	Proteasome subunit beta type-7	Endometrium	-1.887	8
1	PSMB7	Proteasome subunit beta type-7	Haematopoietic and Lymphoid	-1.685	14
2	PSMA6	Proteasome subunit alpha type-6	Head and Neck	-4.829	34
2	PSMA6	Proteasome subunit alpha type-6	Kidney	-4.745	3
2	PSMA6	Proteasome subunit alpha type-6	Central Nervous System	-4.578	33
2	PSMA6	Proteasome subunit alpha type-6	Large Intestine	-4.513	30
2	PSMA6	Proteasome subunit alpha type-6	Skin	-4.432	4
2	PSMA6	Proteasome subunit alpha type-6	Bone	-4.396	12
2	PSMA6	Proteasome subunit alpha type-6	Esophagus	-4.222	26
2	PSMA6	Proteasome subunit alpha type-6	Breast	-4.177	25
2	PSMA6	Proteasome subunit alpha type-6	Lung	-4.063	42
2	PSMA6	Proteasome subunit alpha type-6	Stomach	-4.049	14
2	PSMA6	Proteasome subunit alpha type-6	Pancreas	-3.825	23
2	PSMA6	Proteasome subunit alpha type-6	Endometrium	-3.78	8
2	PSMA6	Proteasome subunit alpha type-6	Ovary	-3.779	31
2	PSMA6	Proteasome subunit alpha type-6	Haematopoietic and Lymphoid	-3.745	14
2	PSMA6	Proteasome subunit alpha type-6	Peripheral Nervous System	-3.503	17
2	PSMA6	Proteasome subunit alpha type-6	Prostate	-2.779	3
3	PSMB2	Proteasome subunit beta type-2	Skin	-4.17	4
3	PSMB2	Proteasome subunit beta type-2	Esophagus	-3.342	26
3	PSMB2	Proteasome subunit beta type-2	Head and Neck	-3.291	34
3	PSMB2	Proteasome subunit beta type-2	Kidney	-3.265	3
3	PSMB2	Proteasome subunit beta type-2	Large Intestine	-3.132	30
3	PSMB2	Proteasome subunit beta type-2	Central Nervous System	-2.963	33
3	PSMB2	Proteasome subunit beta type-2	Haematopoietic and Lymphoid	-2.877	14
3	PSMB2	Proteasome subunit beta type-2	Pancreas	-2.865	23
3	PSMB2	Proteasome subunit beta type-2	Bone	-2.84	12
3	PSMB2	Proteasome subunit beta type-2	Ovary	-2.792	31
3	PSMB2	Proteasome subunit beta type-2	Lung	-2.788	42
3	PSMB2	Proteasome subunit beta type-2	Prostate	-2.633	3
3	PSMB2	Proteasome subunit beta type-2	Breast	-2.622	25
3	PSMB2	Proteasome subunit beta type-2	Peripheral Nervous System	-2.612	17
3	PSMB2	Proteasome subunit beta type-2	Stomach	-2.573	14
3	PSMB2	Proteasome subunit beta type-2	Endometrium	-2.492	8
4	PSMB3	Proteasome subunit beta type-3	Skin	-4.237	4
4	PSMB3	Proteasome subunit beta type-3	Large Intestine	-4.13	30
4	PSMB3	Proteasome subunit beta type-3	Head and Neck	-4.112	34
4	PSMB3	Proteasome subunit beta type-3	Bone	-3.89	12
4	PSMB3	Proteasome subunit beta type-3	Esophagus	-3.86	26
4	PSMB3	Proteasome subunit beta type-3	Pancreas	-3.844	23
4	PSMB3	Proteasome subunit beta type-3	Central Nervous System	-3.639	33
4	PSMB3	Proteasome subunit beta type-3	Ovary	-3.54	31
4	PSMB3	Proteasome subunit beta type-3	Breast	-3.526	25
4	PSMB3	Proteasome subunit beta type-3	Haematopoietic and Lymphoid	-3.385	14
4	PSMB3	Proteasome subunit beta type-3	Lung	-3.336	42
4	PSMB3	Proteasome subunit beta type-3	Kidney	-3.321	3
4	PSMB3	Proteasome subunit beta type-3	Endometrium	-3.295	8
4	PSMB3	Proteasome subunit beta type-3	Stomach	-3.157	14
4	PSMB3	Proteasome subunit beta type-3	Peripheral Nervous System	-2.997	17
4	PSMB3	Proteasome subunit beta type-3	Prostate	-2.537	3
5	PSMB5	Proteasome subunit beta type-5	Skin	-3.678	4
5	PSMB5	Proteasome subunit beta type-5	Bone	-3.555	12
5	PSMB5	Proteasome subunit beta type-5	Large Intestine	-3.259	30
5	PSMB5	Proteasome subunit beta type-5	Esophagus	-3.161	26
5	PSMB5	Proteasome subunit beta type-5	Head and Neck	-3.08	34
5	PSMB5	Proteasome subunit beta type-5	Kidney	-2.835	3
5	PSMB5	Proteasome subunit beta type-5	Lung	-2.729	42
5	PSMB5	Proteasome subunit beta type-5	Peripheral Nervous System	-2.727	17
5	PSMB5	Proteasome subunit beta type-5	Prostate	-2.72	3
5	PSMB5	Proteasome subunit beta type-5	Ovary	-2.687	31
5	PSMB5	Proteasome subunit beta type-5	Endometrium	-2.676	8
5	PSMB5	Proteasome subunit beta type-5	Stomach	-2.662	14
5	PSMB5	Proteasome subunit beta type-5	Central Nervous System	-2.605	33
5	PSMB5	Proteasome subunit beta type-5	Breast	-2.421	25
5	PSMB5	Proteasome subunit beta type-5	Pancreas	-2.202	23
5	PSMB5	Proteasome subunit beta type-5	Haematopoietic and Lymphoid	-1.528	14
6	PSMB6	Proteasome subunit beta type-6	Skin	-3.738	4
6	PSMB6	Proteasome subunit beta type-6	Large Intestine	-3.364	30
6	PSMB6	Proteasome subunit beta type-6	Bone	-3.257	12
6	PSMB6	Proteasome subunit beta type-6	Kidney	-3.132	3
6	PSMB6	Proteasome subunit beta type-6	Stomach	-2.649	14
6	PSMB6	Proteasome subunit beta type-6	Lung	-2.614	42
6	PSMB6	Proteasome subunit beta type-6	Esophagus	-2.609	26
6	PSMB6	Proteasome subunit beta type-6	Head and Neck	-2.554	34
6	PSMB6	Proteasome subunit beta type-6	Peripheral Nervous System	-2.387	17
6	PSMB6	Proteasome subunit beta type-6	Ovary	-2.334	31
6	PSMB6	Proteasome subunit beta type-6	Breast	-2.299	25
6	PSMB6	Proteasome subunit beta type-6	Haematopoietic and Lymphoid	-2.247	14
6	PSMB6	Proteasome subunit beta type-6	Pancreas	-2.214	23
6	PSMB6	Proteasome subunit beta type-6	Prostate	-2.096	3
6	PSMB6	Proteasome subunit beta type-6	Endometrium	-1.866	8
6	PSMB6	Proteasome subunit beta type-6	Central Nervous System	-1.811	33
7	PSMB4	Proteasome subunit beta type-4	Head and Neck	-3.62	34
7	PSMB4	Proteasome subunit beta type-4	Esophagus	-3.384	26
7	PSMB4	Proteasome subunit beta type-4	Stomach	-3.379	14
7	PSMB4	Proteasome subunit beta type-4	Large Intestine	-3.3	30
7	PSMB4	Proteasome subunit beta type-4	Central Nervous System	-3.236	33
7	PSMB4	Proteasome subunit beta type-4	Haematopoietic and Lymphoid	-3.175	14
7	PSMB4	Proteasome subunit beta type-4	Kidney	-3.147	3
7	PSMB4	Proteasome subunit beta type-4	Skin	-2.97	4
7	PSMB4	Proteasome subunit beta type-4	Endometrium	-2.955	8
7	PSMB4	Proteasome subunit beta type-4	Lung	-2.907	42
7	PSMB4	Proteasome subunit beta type-4	Pancreas	-2.886	23
7	PSMB4	Proteasome subunit beta type-4	Ovary	-2.861	31
7	PSMB4	Proteasome subunit beta type-4	Breast	-2.691	25
7	PSMB4	Proteasome subunit beta type-4	Bone	-2.593	12
7	PSMB4	Proteasome subunit beta type-4	Peripheral Nervous System	-2.441	17
7	PSMB4	Proteasome subunit beta type-4	Prostate	-2.253	3
8	PSMA5	Proteasome subunit alpha type-5	Skin	-3.984	4
8	PSMA5	Proteasome subunit alpha type-5	Head and Neck	-3.298	34
8	PSMA5	Proteasome subunit alpha type-5	Esophagus	-3.129	26
8	PSMA5	Proteasome subunit alpha type-5	Haematopoietic and Lymphoid	-3.016	14
8	PSMA5	Proteasome subunit alpha type-5	Large Intestine	-2.89	30
8	PSMA5	Proteasome subunit alpha type-5	Stomach	-2.853	14
8	PSMA5	Proteasome subunit alpha type-5	Breast	-2.689	25
8	PSMA5	Proteasome subunit alpha type-5	Pancreas	-2.629	23
8	PSMA5	Proteasome subunit alpha type-5	Bone	-2.62	12
8	PSMA5	Proteasome subunit alpha type-5	Endometrium	-2.578	8
8	PSMA5	Proteasome subunit alpha type-5	Central Nervous System	-2.545	33
8	PSMA5	Proteasome subunit alpha type-5	Kidney	-2.538	3
8	PSMA5	Proteasome subunit alpha type-5	Peripheral Nervous System	-2.48	17
8	PSMA5	Proteasome subunit alpha type-5	Lung	-2.437	42
8	PSMA5	Proteasome subunit alpha type-5	Ovary	-2.162	31
8	PSMA5	Proteasome subunit alpha type-5	Prostate	-2.043	3
9	PSMA4	Proteasome subunit alpha type-4	Head and Neck	-3.008	34
9	PSMA4	Proteasome subunit alpha type-4	Central Nervous System	-2.632	33
9	PSMA4	Proteasome subunit alpha type-4	Esophagus	-2.604	26
9	PSMA4	Proteasome subunit alpha type-4	Large Intestine	-2.54	30
9	PSMA4	Proteasome subunit alpha type-4	Pancreas	-2.537	23
9	PSMA4	Proteasome subunit alpha type-4	Skin	-2.462	4
9	PSMA4	Proteasome subunit alpha type-4	Kidney	-2.334	3
9	PSMA4	Proteasome subunit alpha type-4	Ovary	-2.259	31
9	PSMA4	Proteasome subunit alpha type-4	Breast	-2.245	25
9	PSMA4	Proteasome subunit alpha type-4	Bone	-2.23	12
9	PSMA4	Proteasome subunit alpha type-4	Stomach	-2.22	14
9	PSMA4	Proteasome subunit alpha type-4	Endometrium	-2.145	8
9	PSMA4	Proteasome subunit alpha type-4	Lung	-2.125	42
9	PSMA4	Proteasome subunit alpha type-4	Haematopoietic and Lymphoid	-1.982	14
9	PSMA4	Proteasome subunit alpha type-4	Peripheral Nervous System	-1.825	17
9	PSMA4	Proteasome subunit alpha type-4	Prostate	-1.226	3
10	PSMA3	Proteasome subunit alpha type-3	Large Intestine	-4.204	30
10	PSMA3	Proteasome subunit alpha type-3	Skin	-4.166	4
10	PSMA3	Proteasome subunit alpha type-3	Breast	-3.983	25
10	PSMA3	Proteasome subunit alpha type-3	Head and Neck	-3.977	34
10	PSMA3	Proteasome subunit alpha type-3	Esophagus	-3.776	26
10	PSMA3	Proteasome subunit alpha type-3	Central Nervous System	-3.703	33
10	PSMA3	Proteasome subunit alpha type-3	Pancreas	-3.646	23
10	PSMA3	Proteasome subunit alpha type-3	Kidney	-3.435	3
10	PSMA3	Proteasome subunit alpha type-3	Lung	-3.39	42
10	PSMA3	Proteasome subunit alpha type-3	Bone	-3.386	12
10	PSMA3	Proteasome subunit alpha type-3	Endometrium	-3.246	8
10	PSMA3	Proteasome subunit alpha type-3	Stomach	-3.109	14
10	PSMA3	Proteasome subunit alpha type-3	Haematopoietic and Lymphoid	-3.039	14
10	PSMA3	Proteasome subunit alpha type-3	Ovary	-2.944	31
10	PSMA3	Proteasome subunit alpha type-3	Peripheral Nervous System	-2.781	17
10	PSMA3	Proteasome subunit alpha type-3	Prostate	-2.178	3
11	PSMA2	Proteasome subunit alpha type-2	Skin	-4.928	4
11	PSMA2	Proteasome subunit alpha type-2	Head and Neck	-4.198	34
11	PSMA2	Proteasome subunit alpha type-2	Esophagus	-3.996	26
11	PSMA2	Proteasome subunit alpha type-2	Large Intestine	-3.939	30
11	PSMA2	Proteasome subunit alpha type-2	Kidney	-3.836	3
11	PSMA2	Proteasome subunit alpha type-2	Central Nervous System	-3.761	33
11	PSMA2	Proteasome subunit alpha type-2	Breast	-3.731	25
11	PSMA2	Proteasome subunit alpha type-2	Haematopoietic and Lymphoid	-3.598	14
11	PSMA2	Proteasome subunit alpha type-2	Pancreas	-3.493	23
11	PSMA2	Proteasome subunit alpha type-2	Endometrium	-3.465	8
11	PSMA2	Proteasome subunit alpha type-2	Lung	-3.354	42
11	PSMA2	Proteasome subunit alpha type-2	Bone	-3.282	12
11	PSMA2	Proteasome subunit alpha type-2	Ovary	-3.179	31
11	PSMA2	Proteasome subunit alpha type-2	Stomach	-3.166	14
11	PSMA2	Proteasome subunit alpha type-2	Prostate	-2.835	3
11	PSMA2	Proteasome subunit alpha type-2	Peripheral Nervous System	-2.506	17
12	PSMA1	Proteasome subunit alpha type-1	Head and Neck	-4.066	34
12	PSMA1	Proteasome subunit alpha type-1	Central Nervous System	-3.991	33
12	PSMA1	Proteasome subunit alpha type-1	Esophagus	-3.932	26
12	PSMA1	Proteasome subunit alpha type-1	Kidney	-3.712	3
12	PSMA1	Proteasome subunit alpha type-1	Bone	-3.6	12
12	PSMA1	Proteasome subunit alpha type-1	Lung	-3.525	42
12	PSMA1	Proteasome subunit alpha type-1	Endometrium	-3.419	8
12	PSMA1	Proteasome subunit alpha type-1	Stomach	-3.356	14
12	PSMA1	Proteasome subunit alpha type-1	Skin	-3.336	4
12	PSMA1	Proteasome subunit alpha type-1	Haematopoietic and Lymphoid	-3.297	14
12	PSMA1	Proteasome subunit alpha type-1	Ovary	-3.095	31
12	PSMA1	Proteasome subunit alpha type-1	Peripheral Nervous System	-3.065	17
12	PSMA1	Proteasome subunit alpha type-1	Breast	-2.676	25
12	PSMA1	Proteasome subunit alpha type-1	Prostate	-2.647	3
12	PSMA1	Proteasome subunit alpha type-1	Large Intestine	-2.631	30
12	PSMA1	Proteasome subunit alpha type-1	Pancreas	-2.496	23
13	PSMB1	Proteasome subunit beta type-1	Esophagus	-3.306	26
13	PSMB1	Proteasome subunit beta type-1	Large Intestine	-3.208	30
13	PSMB1	Proteasome subunit beta type-1	Pancreas	-3.116	23
13	PSMB1	Proteasome subunit beta type-1	Lung	-2.914	42
13	PSMB1	Proteasome subunit beta type-1	Head and Neck	-2.734	34
13	PSMB1	Proteasome subunit beta type-1	Skin	-2.505	4
13	PSMB1	Proteasome subunit beta type-1	Breast	-2.302	25
13	PSMB1	Proteasome subunit beta type-1	Endometrium	-2.277	8
13	PSMB1	Proteasome subunit beta type-1	Stomach	-1.77	14
13	PSMB1	Proteasome subunit beta type-1	Ovary	-1.613	31
13	PSMB1	Proteasome subunit beta type-1	Central Nervous System	-1.594	33
13	PSMB1	Proteasome subunit beta type-1	Bone	-1.531	12
13	PSMB1	Proteasome subunit beta type-1	Kidney	-1.305	3
13	PSMB1	Proteasome subunit beta type-1	Haematopoietic and Lymphoid	-1.279	14
14	PSMA7	Proteasome subunit alpha type-7	Skin	-4.633	4
14	PSMA7	Proteasome subunit alpha type-7	Kidney	-3.662	3
14	PSMA7	Proteasome subunit alpha type-7	Esophagus	-3.578	26
14	PSMA7	Proteasome subunit alpha type-7	Head and Neck	-3.516	34
14	PSMA7	Proteasome subunit alpha type-7	Bone	-3.506	12
14	PSMA7	Proteasome subunit alpha type-7	Haematopoietic and Lymphoid	-3.435	14
14	PSMA7	Proteasome subunit alpha type-7	Large Intestine	-3.395	30
14	PSMA7	Proteasome subunit alpha type-7	Central Nervous System	-3.366	33
14	PSMA7	Proteasome subunit alpha type-7	Pancreas	-3.104	23
14	PSMA7	Proteasome subunit alpha type-7	Lung	-3.068	42
14	PSMA7	Proteasome subunit alpha type-7	Breast	-2.789	25
14	PSMA7	Proteasome subunit alpha type-7	Ovary	-2.682	31
14	PSMA7	Proteasome subunit alpha type-7	Peripheral Nervous System	-2.504	17
14	PSMA7	Proteasome subunit alpha type-7	Endometrium	-2.463	8
14	PSMA7	Proteasome subunit alpha type-7	Stomach	-2.461	14
14	PSMA7	Proteasome subunit alpha type-7	Prostate	-2.319	3