| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | RHEB | GTP-binding protein Rheb | Stomach | -2.408 | 14 |
| 1 | RHEB | GTP-binding protein Rheb | Head and Neck | -2.378 | 34 |
| 1 | RHEB | GTP-binding protein Rheb | Large Intestine | -2.337 | 30 |
| 1 | RHEB | GTP-binding protein Rheb | Bone | -2.325 | 12 |
| 1 | RHEB | GTP-binding protein Rheb | Kidney | -2.166 | 3 |
| 1 | RHEB | GTP-binding protein Rheb | Esophagus | -1.969 | 26 |
| 1 | RHEB | GTP-binding protein Rheb | Breast | -1.967 | 25 |
| 1 | RHEB | GTP-binding protein Rheb | Pancreas | -1.836 | 23 |
| 1 | RHEB | GTP-binding protein Rheb | Central Nervous System | -1.76 | 33 |
| 1 | RHEB | GTP-binding protein Rheb | Skin | -1.74 | 4 |
| 1 | RHEB | GTP-binding protein Rheb | Lung | -1.609 | 42 |
| 1 | RHEB | GTP-binding protein Rheb | Ovary | -1.584 | 31 |
| 1 | RHEB | GTP-binding protein Rheb | Prostate | -1.267 | 3 |
| 1 | RHEB | GTP-binding protein Rheb | Endometrium | -1.081 | 8 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Skin | -2.568 | 4 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Kidney | -2.555 | 3 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Esophagus | -1.555 | 26 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Head and Neck | -1.415 | 34 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Stomach | -1.407 | 14 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Large Intestine | -1.405 | 30 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Central Nervous System | -1.402 | 33 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Peripheral Nervous System | -1.303 | 17 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Pancreas | -1.265 | 23 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Bone | -1.238 | 12 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Prostate | -1.168 | 3 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Breast | -1.067 | 25 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Ovary | -1.04 | 31 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Endometrium | -1.026 | 8 |
| 2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | Lung | -1.003 | 42 |
| 3 | RAN | GTP-binding nuclear protein Ran | Skin | -6.146 | 4 |
| 3 | RAN | GTP-binding nuclear protein Ran | Esophagus | -5.632 | 26 |
| 3 | RAN | GTP-binding nuclear protein Ran | Large Intestine | -5.526 | 30 |
| 3 | RAN | GTP-binding nuclear protein Ran | Head and Neck | -5.426 | 34 |
| 3 | RAN | GTP-binding nuclear protein Ran | Bone | -5.295 | 12 |
| 3 | RAN | GTP-binding nuclear protein Ran | Endometrium | -5.098 | 8 |
| 3 | RAN | GTP-binding nuclear protein Ran | Kidney | -5.034 | 3 |
| 3 | RAN | GTP-binding nuclear protein Ran | Breast | -4.991 | 25 |
| 3 | RAN | GTP-binding nuclear protein Ran | Central Nervous System | -4.937 | 33 |
| 3 | RAN | GTP-binding nuclear protein Ran | Lung | -4.873 | 42 |
| 3 | RAN | GTP-binding nuclear protein Ran | Pancreas | -4.757 | 23 |
| 3 | RAN | GTP-binding nuclear protein Ran | Haematopoietic and Lymphoid | -4.567 | 14 |
| 3 | RAN | GTP-binding nuclear protein Ran | Stomach | -4.557 | 14 |
| 3 | RAN | GTP-binding nuclear protein Ran | Ovary | -4.362 | 31 |
| 3 | RAN | GTP-binding nuclear protein Ran | Prostate | -4.245 | 3 |
| 3 | RAN | GTP-binding nuclear protein Ran | Peripheral Nervous System | -4.09 | 17 |
| 4 | CDC42 | Cell division control protein 42 homolog | Skin | -2.544 | 4 |
| 4 | CDC42 | Cell division control protein 42 homolog | Kidney | -2.092 | 3 |
| 4 | CDC42 | Cell division control protein 42 homolog | Stomach | -1.978 | 14 |
| 4 | CDC42 | Cell division control protein 42 homolog | Bone | -1.866 | 12 |
| 4 | CDC42 | Cell division control protein 42 homolog | Head and Neck | -1.641 | 34 |
| 4 | CDC42 | Cell division control protein 42 homolog | Haematopoietic and Lymphoid | -1.526 | 14 |
| 4 | CDC42 | Cell division control protein 42 homolog | Central Nervous System | -1.498 | 33 |
| 4 | CDC42 | Cell division control protein 42 homolog | Esophagus | -1.487 | 26 |
| 4 | CDC42 | Cell division control protein 42 homolog | Ovary | -1.299 | 31 |
| 4 | CDC42 | Cell division control protein 42 homolog | Peripheral Nervous System | -1.266 | 17 |
| 4 | CDC42 | Cell division control protein 42 homolog | Prostate | -1.236 | 3 |
| 4 | CDC42 | Cell division control protein 42 homolog | Pancreas | -1.193 | 23 |
| 4 | CDC42 | Cell division control protein 42 homolog | Endometrium | -1.055 | 8 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Prostate | -1.786 | 3 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Haematopoietic and Lymphoid | -1.56 | 14 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Bone | -1.451 | 12 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Large Intestine | -1.394 | 30 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Breast | -1.368 | 25 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Head and Neck | -1.296 | 34 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Endometrium | -1.267 | 8 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Peripheral Nervous System | -1.209 | 17 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Ovary | -1.13 | 31 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Lung | -1.12 | 42 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Pancreas | -1.1 | 23 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Kidney | -1.069 | 3 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Central Nervous System | -1.062 | 33 |
| 5 | RHOQ | Rho-related GTP-binding protein RhoQ | Esophagus | -1.013 | 26 |