| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | PPIL1 | Peptidyl-prolyl cis-trans isomerase-like 1 | Bone | -1.691 | 12 |
| 1 | PPIL1 | Peptidyl-prolyl cis-trans isomerase-like 1 | Peripheral Nervous System | -1.384 | 17 |
| 1 | PPIL1 | Peptidyl-prolyl cis-trans isomerase-like 1 | Prostate | -1.252 | 3 |
| 1 | PPIL1 | Peptidyl-prolyl cis-trans isomerase-like 1 | Haematopoietic and Lymphoid | -1.021 | 14 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Head and Neck | -3.982 | 34 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Bone | -3.878 | 12 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Haematopoietic and Lymphoid | -3.536 | 14 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Esophagus | -3.312 | 26 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Stomach | -3.101 | 14 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Large Intestine | -2.93 | 30 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Central Nervous System | -2.828 | 33 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Ovary | -2.704 | 31 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Skin | -2.632 | 4 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Endometrium | -2.618 | 8 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Breast | -2.602 | 25 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Kidney | -2.462 | 3 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Lung | -2.442 | 42 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Pancreas | -2.283 | 23 |
| 2 | PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | Peripheral Nervous System | -1.653 | 17 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Large Intestine | -1.881 | 30 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Skin | -1.828 | 4 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Head and Neck | -1.694 | 34 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Esophagus | -1.624 | 26 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Breast | -1.531 | 25 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Pancreas | -1.497 | 23 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Ovary | -1.423 | 31 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Kidney | -1.41 | 3 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Peripheral Nervous System | -1.395 | 17 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Haematopoietic and Lymphoid | -1.334 | 14 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Bone | -1.265 | 12 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Stomach | -1.077 | 14 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Lung | -1.066 | 42 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Endometrium | -1.028 | 8 |
| 3 | PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 | Central Nervous System | -1.004 | 33 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Skin | -3.703 | 4 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Head and Neck | -3.295 | 34 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Bone | -3.074 | 12 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Large Intestine | -2.917 | 30 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Breast | -2.581 | 25 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Haematopoietic and Lymphoid | -2.558 | 14 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Stomach | -2.538 | 14 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Kidney | -2.464 | 3 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Central Nervous System | -2.444 | 33 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Esophagus | -2.436 | 26 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Lung | -2.342 | 42 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Ovary | -2.259 | 31 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Pancreas | -2.236 | 23 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Peripheral Nervous System | -2.22 | 17 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Prostate | -1.719 | 3 |
| 4 | PPIL2 | RING-type E3 ubiquitin-protein ligase PPIL2 | Endometrium | -1.511 | 8 |
| 5 | PPIA | Peptidyl-prolyl cis-trans isomerase A | Kidney | -1.803 | 3 |
| 5 | PPIA | Peptidyl-prolyl cis-trans isomerase A | Haematopoietic and Lymphoid | -1.781 | 14 |
| 5 | PPIA | Peptidyl-prolyl cis-trans isomerase A | Head and Neck | -1.609 | 34 |
| 5 | PPIA | Peptidyl-prolyl cis-trans isomerase A | Skin | -1.58 | 4 |
| 5 | PPIA | Peptidyl-prolyl cis-trans isomerase A | Large Intestine | -1.539 | 30 |
| 5 | PPIA | Peptidyl-prolyl cis-trans isomerase A | Prostate | -1.481 | 3 |
| 5 | PPIA | Peptidyl-prolyl cis-trans isomerase A | Endometrium | -1.163 | 8 |
| 5 | PPIA | Peptidyl-prolyl cis-trans isomerase A | Esophagus | -1.12 | 26 |
| 5 | PPIA | Peptidyl-prolyl cis-trans isomerase A | Stomach | -1.034 | 14 |
| 6 | PPIAL4G | Peptidyl-prolyl cis-trans isomerase A-like 4G | Large Intestine | -1.488 | 30 |
| 6 | PPIAL4G | Peptidyl-prolyl cis-trans isomerase A-like 4G | Kidney | -1.348 | 3 |
| 6 | PPIAL4G | Peptidyl-prolyl cis-trans isomerase A-like 4G | Breast | -1.218 | 25 |
| 6 | PPIAL4G | Peptidyl-prolyl cis-trans isomerase A-like 4G | Head and Neck | -1.21 | 34 |