The Ligandable Human Proteome

Histidine kinase/HSP90-like ATPase

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	HSP90B1	Endoplasmin	Skin	-1.688	4
1	HSP90B1	Endoplasmin	Haematopoietic and Lymphoid	-1.279	14
1	HSP90B1	Endoplasmin	Pancreas	-1.228	23
1	HSP90B1	Endoplasmin	Large Intestine	-1.12	30
2	TOP2A	DNA topoisomerase 2-alpha	Head and Neck	-4.156	34
2	TOP2A	DNA topoisomerase 2-alpha	Skin	-4.148	4
2	TOP2A	DNA topoisomerase 2-alpha	Esophagus	-3.608	26
2	TOP2A	DNA topoisomerase 2-alpha	Kidney	-3.581	3
2	TOP2A	DNA topoisomerase 2-alpha	Large Intestine	-3.527	30
2	TOP2A	DNA topoisomerase 2-alpha	Bone	-3.309	12
2	TOP2A	DNA topoisomerase 2-alpha	Central Nervous System	-3.206	33
2	TOP2A	DNA topoisomerase 2-alpha	Lung	-2.985	42
2	TOP2A	DNA topoisomerase 2-alpha	Haematopoietic and Lymphoid	-2.717	14
2	TOP2A	DNA topoisomerase 2-alpha	Stomach	-2.712	14
2	TOP2A	DNA topoisomerase 2-alpha	Ovary	-2.605	31
2	TOP2A	DNA topoisomerase 2-alpha	Peripheral Nervous System	-2.389	17
2	TOP2A	DNA topoisomerase 2-alpha	Endometrium	-2.375	8
2	TOP2A	DNA topoisomerase 2-alpha	Pancreas	-2.351	23
2	TOP2A	DNA topoisomerase 2-alpha	Prostate	-2.252	3
2	TOP2A	DNA topoisomerase 2-alpha	Breast	-2.088	25