| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | PYROXD1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 | Head and Neck | -1.445 | 34 |
| 1 | PYROXD1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 | Large Intestine | -1.371 | 30 |
| 1 | PYROXD1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 | Esophagus | -1.354 | 26 |
| 1 | PYROXD1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 | Skin | -1.273 | 4 |
| 1 | PYROXD1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 | Stomach | -1.267 | 14 |
| 1 | PYROXD1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 | Bone | -1.012 | 12 |