The Ligandable Human Proteome

Tyrosine-protein phosphatase non-receptor type 11

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	5od	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP504	6bmw	90.86
2	5od	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP244	6bmu	90.64
3	5od	Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor	6cms	90.62
4	5od	Closed structure of active SHP2 mutant E76D bound to SHP099 inhibitor	6cmr	90.57
5	5od	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP099	5ehr	90.51
6	5od	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP844	6bmy	89.97
7	je1	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrimidinone 7	6md7	88.47
8	5oa	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP836	5ehp	88.24
9	5od	Crystal Structure of Shp2 E76K GOF Mutant in complex with SHP099	6crg	88.06
10	je4	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 5	6mdb	86
11	je7	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Imidazo-pyridine 24	6mdd	84.05
12	jea	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 1 SHP389	6mdc	83.29
13	dzj	Non-receptor Protein Tyrosine Phosphatase SHP2 F285S in Complex with Allosteric Inhibitor JLR-2	6bn5	72.6
14	3lu	Co-crystal structure of SHP2 in complex with a Cefsulodin derivative	4rdd	55.82
15	jzg	Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor	3o5x	49.08
16	2wt	Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79	4pvg	37.56