The Ligandable Human Proteome

Adenosine receptor A2a

G protein-coupled receptor, rhodopsin-like

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	t4e	Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 1.86A obtained from in meso soaking experiments (24 hour soak).	5om4	96.38
2	t4e	Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 1.9A obtained from bespoke co-crystallisation experiments.	5olz	96.22
3	t4e	Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 2.1A obtained from in meso soaking experiments (1 hour soak).	5om1	96.13
4	nec	Thermostabilised HUMAN A2a Receptor with NECA bound	2ydv	94.64
5	adn	Thermostabilised HUMAN A2a Receptor with adenosine bound	2ydo	92.74
6	8jn	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with PSB36 at 2.8A resolution	5n2r	92.7
7	9y2	Structure of the A2A-StaR2-bRIL562-LUAA47070 complex at 2.0A obtained from in meso soaking experiments.	5olv	88.76
8	zma	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with ZM241385 at 1.7A resolution	5iu4	83.76
9	zma	A2A Adenosine receptor cryo structure	5nm2	82.79
10	zma	2.5 angstrom A2a adenosine receptor structure with sulfur SAD phasing using XFEL data	5k2a	82
11	zma	The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.	3eml	81.93
12	zma	Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris	6aqf	81.85
13	zma	Structure of human A2A adenosine receptor in complex with ZM241385 obtained from SFX experiments under atmospheric pressure	6jzh	81.79
14	zma	Structure of the A2A-StaR2-bRIL562-ZM241385 complex at 1.86A obtained from in meso soaking experiments.	5olg	81.56
15	zma	2.5 angstrom A2a adenosine receptor structure with MR phasing using XFEL data	5k2b	81.54
16	zma	Crystal structure of the chimeric protein of A2aAR-BRIL with bound iodide ions	5jtb	81.22
17	zma	Crystal structure of the chimeric protein of A2aAR-BRIL in complex with ZM241385 at 1.8A resolution	4eiy	81.12
18	zma	2.35-Angstrom In situ Mylar structure of human A2A adenosine receptor at 100 K	5vra	80.8
19	zma	1.9A angstrom A2a adenosine receptor structure with MR phasing using XFEL data	5k2d	80.34
20	zma	1.9 angstrom A2a adenosine receptor structure with sulfur SAD phasing and phase extension using XFEL data	5k2c	80.07
21	6dz	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12f at 2.0A resolution	5iu8	78.56
22	6dx	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12b at 2.2A resolution	5iua	77.39
23	zma	Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 2.7 A resolution	3vg9	76.28
24	6dv	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12x at 2.1A resolution	5iub	75.83
25	6dy	Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12c at 1.9A resolution	5iu7	75.81
26	clr	A2A Adenosine receptor room-temperature structure determined by serial millisecond crystallography	5nlx	71.91