The Ligandable Human Proteome

Aurora kinase A

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	ak6	Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 823.	3dj6	94.91
2	ak5	Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290.	3dj5	94.37
3	ak7	Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 130.	3dj7	94.32
4	ak1	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]- thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea	3d14	93.34
5	cj5	Aurora A in complex with CD532	4j8m	93.29
6	0c4	Aurora A in complex with RPM1722	3uoh	93.23
7	0bz	Aurora A in Complex with RPM1679	3unz	92.7
8	ak3	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylamino)-ethyl]-thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea	3d2i	92.23
9	ak2	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-(3-chloro-phenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)- ethyl]-thiazol-2-yl}-urea [SNS-314]	3d15	92.19
10	0c6	Aurora A in complex with YL5-81-1	3uok	90.81
11	ak4	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with [7-(2-{2-[3-(3-chloro-phenyl)-ureido]-thiazol-5-yl}-ethylamino)-pyrazolo[4,3-d]pyrimidin-1-yl]-acetic acid	3d2k	90.76
12	f8z	Human AURKA bound to BRD-7880	6gra	90.17
13	0c8	Aurora A in complex with RPM1686	3up2	88.39
14	0by	Aurora A in complex with YL5-083	3uo6	87.92
15	4rj	Human Aurora A catalytic domain bound to FK1141	4ztr	87.68
16	zzl	Aurora-A Inhibitor Structure	2wtv	87.64
17	adn	Crystal structures of human kinase Aurora A	4o0s	87.58
18	0c5	Aurora A in complex with RPM1715	3uoj	87.44
19	g7w	Crystal Structure of Aurora-A L210C catalytic domain in complex with ASDO2	6hjk	87.02
20	5vc	Crystal Structure of Aurora A Kinase Domain Bound to MK-5108	5ew9	86.68
21	ak8	Structure of AuroraA with pyridyl-pyrimidine urea inhibitor	3efw	86.26
22	y3m	SAR156497 an exquisitely selective inhibitor of Aurora kinases	4uyn	85.97
23	0c0	Aurora A in complex with RPM1680	3uo4	85.56
24	n15	Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XV	3w2c	85.3
25	0c3	Aurora A in complex with RPM1693	3uod	85.28
26	0c7	Aurora A in complex with SO2-162	3uol	85.15
27	aki	Crystal Structure of Aurora A Kinase complexed with inhibitor	3m11	85.1
28	vek	Complex of Aurora-A bound to an Imidazopyridine-based inhibitor	4b0g	84.76
29	9qk	Aurora A kinase in complex with 2-(3-fluorophenyl)quinoline-4-carboxylic acid and ATP	5obj	84.5
30	g7t	Crystal structure of Aurora-A L210C catalytic domain in complex with ASDO6 ligand	6hjj	84.44
31	4rm	Human Aurora A catalytic domain bound to FK932	4ztq	84.33
32	ske	Aurora A Kinase in Complex with JNJ-7706621 in Space Group P6122	5dt0	84.05
33	lje	Crystal structure of benzamide 9 bound to AuroraA	3o50	83.81
34	4rk	Human Aurora A catalytic domain bound to FK1142	4zts	83.78
35	5dn	Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122	5dpv	82.61
36	fh5	Aurora A kinase bound to a highly selective imidazopyridine inhibitor	4byj	82.31
37	vx6	Crystal structure of Aurora A in complex with VX-680 and TPX2	3e5a	82.04
38	adn	CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE	1muo	81.99
39	0bx	Aurora A in complex with YL1-038-31	3uo5	81.98
40	wph	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	4jbo	81.98
41	ske	Aurora A Kinase in Complex with AA29 and JNJ-7706621 in Space Group P6122	5dr9	81.74
42	jve	SAR156497 an exquisitely selective inhibitor of Aurora kinases	4uzh	81.67
43	ske	Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122	5dr6	81.67
44	ske	Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122	5dpv	81.5
45	5e1	Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122	5dr6	81.49
46	5e1	Aurora A Kinase in Complex with AA30 and ATP in Space Group P6122	5dr2	81.43
47	a4w	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5orl	81.16
48	pfq	Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor	3k5u	80.92
49	yph	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	4jbp	80.38
50	adn	Crystal structures of human kinase Aurora A	4o0w	79.94
51	hpm	Aurora A kinase activated mutant (T287D) in complex with a 5- aminopyrimidinyl quinazoline inhibitor	2c6e	79.76
52	l0f	Structure determination of Aurora Kinase in complex with inhibitor	2w1f	79.47
53	adn	Crystal structures of human kinase Aurora A	4o0u	79.16
54	5dn	Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122	5dos	79.11
55	2vu	Aurora A kinase domain with compound 2 (N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide)	4prj	78.81
56	vx6	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	4jbq	78.65
57	a8h	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5os4	78.49
58	ofi	Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor	3lau	78.43
59	eg7	Aurora A ligand complex	6c2r	78.34
60	l0e	Structure determination of Aurora Kinase in complex with inhibitor	2w1e	78.21
61	x6d	Aurora-A bound to an inhibitor	2x6d	77.9
62	ske	Aurora A kinase in complex with 2-(3-chloro-5-fluorophenyl)quinoline-4-carboxylic acid and JNJ-7706621	5obr	77.65
63	0fy	Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity	3vap	77.55
64	97b	Aurora A inhibitor complex	3h10	77.28
65	d37	Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)	3r22	76.97
66	5dn	Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122	5dt4	76.88
67	nhi	Aurora A in complex with YL1-038-18	4dea	76.77
68	n13	Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XIII	3w18	76.38
69	cc3	Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors	2np8	76.32
70	p9j	Aurora A kinase domain with phthalazinone pyrazole inhibitor	3p9j	75.98
71	fxg	Crystal structure of Aurora A complexed with an inhibitor discovered through site-directed dynamic tethering	3daj	75.66
72	400	AURORA-A T288E COMPLEXED WITH PHA-828300	2xru	75.58
73	fh3	Aurora A kinase bound to a highly selective imidazopyridine inhibitor	4byi	75.08
74	zzl	STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054	2x81	75.04
75	eml	Aurora A Kinase complexed with SCH 1473759	3myg	74.68
76	nl4	Aurora A kinase bound to an imidazopyridine inhibitor (14a)	5aaf	74.6
77	d36	Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)	3r21	74.48
78	626	Structure of Aurora-2 in complex with PHA-680626	2j4z	74.31
79	jrw	Aurora-A in complex with shape-diverse fragment 58	6r4d	73.44
80	p9j	Structure of Aurora kinase A complexed to pyrazole-aminoquinoline inhibitor III	3w16	73.32
81	a5w	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5ors	72.77
82	45b	Aurora A in complex with a bisanilinopyrimidine	3h0z	72
83	48b	Aurora A in complex with a bisanilinopyrimidine	3h0y	71.98
84	mmh	Structure-based drug design of novel Aurora kinase A inhibitors: Structure basis for potency and specificity	3fdn	71.39
85	0k6	Structure of Aurora A mutant bound to Biogenidec cpd 15	4dhf	71.02
86	2jz	Crystal structure of aurora A in complex with TPX2 and compound 10	3ha6	70.21
87	627	Structure of Aurora-2 in complex with PHA-739358	2j50	69.64
88	9yq	Crystal structure of Aurora-A in complex with FMF-03-145-1 (compound 2)	5one	69.44
89	35r	Structure of dephosphorylated Aurora A (122-403) in complex with inhibiting monobody and AT9283 in an inactive conformation	6cpg	68.67
90	l0g	Structure determination of Aurora Kinase in complex with inhibitor	2w1g	68.29
91	jsb	Aurora-A in complex with shape-diverse fragment 39	6r49	67.51
92	egj	Aurora A ligand complex	6c2t	67.46
93	6f2	Aurora A kinase bound to an imidazopyridine inhibitor (14b)	5aag	67.38
94	5dn	Aurora A in complex with ATP and AA35.	5dn3	66.79
95	9a6	Crystal Structure of Aurora-A in complex with a new Quinazoline inhibitor	5zan	66.66
96	jsn	Aurora-A in complex with shape-diverse fragment 56	6r4b	66.29
97	a0h	Structure of Aurora-A bound to a selective imidazopyrazine inhibitor	2xng	65.49
98	mpy	Aurora-2 T287D T288D complexed with PHA-680632	2bmc	63.69
99	a5h	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5oro	59.98
100	a9e	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5osf	53.01