| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | 4e2 | Crystal structure of DYRK1A in complex with 10-Chloro-substituted 11H-indolo[3,2-c]quinolone-6-carboxylic acid inhibitor 5s | 4ylk | 89.42 |
| 2 | d15 | Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A | 2vx3 | 88.67 |
| 3 | ehb | human DYRK1A/inhibitor complex | 3anq | 86.95 |
| 4 | 2c4 | The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor | 4mq2 | 86.66 |
| 5 | 4e1 | Crystal structure of DYRK1A in complex with 10-Iodo-substituted 11H-indolo[3,2-c]quinoline-6-carboxylic acid inhibitor 5j | 4ylj | 85.87 |
| 6 | 2c3 | The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor | 4mq1 | 85.16 |
| 7 | b7b | DYRK1A in complex with XMD8-62e | 6eip | 82.53 |
| 8 | b6b | DYRK1A in complex with XMD8-49 | 6eil | 80.98 |
| 9 | d15 | Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in complex with a consensus substrate peptide | 2wo6 | 78.4 |
| 10 | 9ol | Crystal structure of human DYRK1A in complex with compound 32 | 6a1g | 75.82 |
| 11 | b5t | DYRK1A in complex with XMD7-117 | 6eif | 75.43 |
| 12 | b6q | DYRK1A in complex with JWD-065 | 6eiv | 74.67 |
| 13 | b5z | DYRK1A in complex with HG-8-60-1 | 6eij | 73.35 |
| 14 | b6z | DYRK1A in complex with XMD14-124 | 6eiq | 71.16 |
| 15 | b6h | DYRK1A in complex with XMD15-27-2 | 6eir | 64.33 |