The Ligandable Human Proteome

Fibroblast growth factor receptor 1

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	c4f	FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole	3c4f	97.15
2	lev	FGFR-1 in complex with ligand lenvatinib	5zv2	94.69
3	0li	FGFR1 in complex with ponatinib.	4v04	92.57
4	2k5	Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 1	4nk9	90.41
5	3rh	Crystal structure of the catalytic domain of FGFR1 kinase in complex with ARQ 069	3rhx	89.87
6	0li	FGFR1 in complex with ponatinib (co-crystallisation).	4v01	89.84
7	0s9	Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 8	4f65	88.6
8	tz0	TAS-120 covalent complex with FGFR1	6mzw	87.14
9	xl6	FGFR1 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide	6nvl	86.8
10	su1	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR	1fgi	85.18
11	tz0	TAS-120 in reversible binding mode with FGFR1	6mzq	83.6
12	2m2	Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 3	4nks	82.46
13	0s8	Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 6	4f64	82.1
14	gql	Crystal Structure of activated receptor tyrosine kinase in complex with substrates	3gql	81.5
15	2k7	Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 2	4nka	81.1
16	o1y	Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 22.	6p68	80.27
17	66t	FGFR1 in complex with AZD4547.	4v05	79.61
18	xoj	FGFR1 ligand complex	5a4c	78.57
19	yy7	FGFR1 kinase complex with inhibitor SN36985	6c19	77.88
20	o21	Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 11.	6p69	76.94
21	yy4	FGFR1 kinase complex with inhibitor SN37118	6c1b	76.85
22	66t	Structure of FGFR1 in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE) at 1.65 angstrom	4wun	76.81
23	66t	Crystal Structure of FGFR1 (C488A, C584S) in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE)	4rwj	76.18
24	yy5	FGFR1 kinase complex with inhibitor SN37115	6c18	75.85
25	0s7	Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 1	4f63	75.79
26	9k5	Human FGF in complex with a covalent inhibitor	5o49	74.86
27	07j	Co-structure of Fibroblast Growth Factor Receptor 1 kinase domain with 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (BGJ398)	3tt0	73.13
28	4ut	Crystal structure of FGFR1 kinase domain in complex with 7n	4zsa	72.9
29	9es	Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527	5vnd	72.89
30	9k8	Human FGF in complex with a covalent inhibitor	5o4a	70.19
31	pd1	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074	2fgi	69.2
32	66t	Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M) in complex with N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE (AZD4547)	4rwk	67.81
33	38o	Native FGFR1 with an inhibitor	5am6	65.09
34	38o	FGFR1 in complex with dovitinib	5a46	64.85
35	38o	FGFR1 mutant with an inhibitor	5am7	64.62
36	su2	CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR	1agw	64.34
37	jvt	Fibroblast growth factor receptor 1 kinase in complex with JK-P5	4uwb	61.45