The Ligandable Human Proteome

cAMP-dependent protein kinase catalytic subunit alpha

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	adn	CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE	1fmo	96.73
2	xfe	Human cyclic AMP-dependent protein kinase PKA inhibitor complex	3mvj	95.49
3	l9n	crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27	3l9n	94.54
4	m05	Structure of PKA-PKB chimera complexed with 4-(4-Chlorobenzyl)-1-(7H- pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-ylamine	2vo6	94.49
5	l9l	Crystal structure of pka with compound 36	3l9l	94.19
6	4l7	Protein Kinase A in complex with an Inhibitor	4uja	93.99
7	m04	Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorophenyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine	2vo3	93.89
8	l9m	Crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 18	3l9m	93.71
9	s69	human cAMP-dependent protein kinase in complex with an inhibitor	3poo	93.66
10	s3n	Protein Kinase A in complex with an Inhibitor	4uj9	93.52
11	r69	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh4	93.51
12	r69	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh9	93.49
13	gvn	Structure of PKA-PKB chimera complexed with (R)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine	2uw5	93.15
14	nu3	PKA-S6K1 Chimera with compound 1 (NU1085) bound	4c35	92.92
15	m01	Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)methanamine	2vnw	92.82
16	gvk	Structure of PKA-PKB chimera complexed with 6-(4-(4-(4-Chloro-phenyl) -piperidin-4-yl)-phenyl)-9H-purine	2uw0	92.61
17	796	Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies	2gu8	92.26
18	nvx	PKAB3 in complex with pyrrolidine inhibitor 34a	4z84	91.6
19	bd2	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2	1re8	91.5
20	r55	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh8	91.44
21	r94	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh6	91.43
22	3sb	Human cAMP-dependent protein kinase in complex with an inhibitor	3oxt	91.42
23	r68	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xha	91.38
24	r96	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh7	91.25
25	47v	cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 2,5-dimethyl-N-pyridin-4-ylfuran-3-carboxamide	5n1l	91.25
26	r68	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants	1xh5	91.21
27	ptv	Bovine PKA C-alpha in complex with 2-[[5-(4-pyridyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-1-(2-thiophenyl)ethanone	4ij9	91.1
28	gvj	Structure of PKA-PKB chimera complexed with C-Phenyl-C-(4-(9H-purin-6- yl)-phenyl)-methylamine	2uvz	90.86
29	9nt	cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule N-(1,3-benzodioxol-5-yl)-2-piperidin-1-ylacetamide	5n1e	90.51
30	8bq	Protein Kinase A in complex with an Inhibitor	4ujb	90.29
31	b1l	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1	1rej	90.02
32	35r	Protein kinase A mutants as surrogate model for Aurora B with AT9283 inhibitor	5n23	89.63
33	pzx	Bovine PKA C-alpha in complex with 3-pyridylmethyl-5-methyl-1H-pyrazole-3-carboxylate	4ie9	89.55
34	nvx	Protein Kinase A in complex with an Inhibitor	4uj1	89.5
35	nvv	Protein Kinase A in complex with an Inhibitor	4uj2	89.32
36	ee4	Crystal structure of cAMP-dependent protein kinase Calpha subunit bound with N46	6c0u	89.18
37	ske	Protein kinase A sixfold mutant model of Aurora B with inhibitor JNJ-7706621	3ama	88.79
38	gvq	Structure of PKA-PKB chimera complexed with 2-(4-chloro-phenyl)-2- phenyl-ethylamine	2uw8	88.53
39	b8l	Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 8	1rek	88.44
40	2sb	Human cAMP-dependent protein kinase in complex with an inhibitor	3owp	88.32
41	gvo	Structure of PKA-PKB chimera complexed with (S)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine	2uw6	88.02
42	y27	The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632	1q8t	87.89
43	9cy	Crystal structure of Protein Kinase A in complex with the PKI peptide and Aminobenzothiazole based inhibitor	5vhb	86.42
44	l20	Structure of cAMP-dependent protein kinase complexed with A-443654	2jds	86.19
45	4sb	Human cAMP-dependent protein kinase in complex with an inhibitor	3p0m	85.82
46	b99	Structure of PKA with a protein Kinase B-selective inhibitor.	3kkv	85.76
47	8et	cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule N-quinolin-5-ylpyridine-3-carboxamide	5n1f	85.45
48	j0p	Crystal structure of Protein Kinase A in complex with the PKI peptide and a pyridinylbenzamide based inhibitor	6e9l	85.26
49	2ea	PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine	2f7e	84.98
50	l20	PKA structures of indazole-pyridine series of AKT inhibitors	2uzu	84.92
51	vx6	Protein kinase A sixfold mutant model of Aurora B with inhibitor VX-680	3amb	80.98
52	9d4	Crystal structure of Protein Kinase A in complex with the PKI peptide and Aminobenzothiazole based inhibitors	5vi9	78.65
53	ss5	PKA structures of indazole-pyridine series of AKT inhibitors	2uzv	78.08