| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | 0jg | Rsk2 C-terminal Kinase Domain with inhibitor (E)-methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate | 4d9t | 79.94 |
| 2 | 584 | Rsk2 N-terminal Kinase in Complex with BI-D1870 | 5d9k | 78.73 |
| 3 | 2ns | Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27 | 4nw6 | 78.34 |
| 4 | 2nr | Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8 | 4nw5 | 77.72 |
| 5 | 2nk | Rsk2 N-terminal kinase in complex with LJH685 | 4nus | 75.57 |