| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | fpu | Crystal structure of SYK kinase domain with 1-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-3-((1R,2S)-2-phenylcyclopropyl)urea | 3tub | 93.21 |
| 2 | 3yx | SYK Catalytic Domain Complexed with a Potent Triazine Inhibitor2 | 4rx8 | 90.45 |
| 3 | 1b6 | Crystal structure of spleen tyrosine kinase complexed with 2-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide | 4i0t | 90.13 |
| 4 | fpx | Crystal structure of SYK kinase domain with N-(4-methyl-3-(8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide | 3tud | 89.99 |
| 5 | 0vh | Crystal structure of spleen tyrosine kinase complexed with 6-((1R,2S)-2-Amino-cyclohexylamino)-4-(6-ethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide | 4fz7 | 88.96 |
| 6 | 3yv | SYK Catalytic Domain Complexed with a Potent Triazine Inhibitor | 4rx7 | 87.9 |
| 7 | 55y | SYK catalytic domain complexed with a potent and orally bioavailable benzisothiazole inhibitor | 5cy3 | 87.82 |
| 8 | p5c | Crystal structure of spleen tyrosine kinase complexed with YM193306 | 3fqe | 87.54 |
| 9 | fpw | Crystal structure of SYK kinase domain with 1-benzyl-N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide | 3tuc | 87.23 |
| 10 | 4dk | SYK kinase domain in complex with inhibitor GTC000224 | 4yjq | 86.99 |
| 11 | 7kg | Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK) | 5tr6 | 86.53 |
| 12 | 55m | SYK catalytic domain complexed with a potent orally bioavailable thiazole inhibitor | 5cxh | 86.17 |
| 13 | 0k1 | Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor | 4dfn | 86.06 |
| 14 | s19 | Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor | 3srv | 85.75 |
| 15 | x8g | Crystal structure of an inhibitor-bound Syk | 4xg8 | 85.3 |
| 16 | 1b5 | Crystal structure of spleen tyrosine kinase complexed with 2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide | 4i0s | 85.03 |
| 17 | 2x6 | SYK catalytic domain in complex with a potent pyridopyrimidinone inhibitor | 4px6 | 84.75 |
| 18 | x6g | Crystal structure of an inhibitor-bound Syk | 4xg6 | 83.95 |
| 19 | 4dt | THE KINASE DOMAIN OF HUMAN SPLEEN TYROSINE (SYK) IN COMPLEX WITH GTC000250 | 4yjv | 83.75 |
| 20 | 7cu | Crystal structure of SYK kinase domain with inhibitor | 5tiu | 83.08 |
| 21 | 0xf | Crystal structure of spleen tyrosine kinase complexed with r9021 | 4gfg | 82.94 |
| 22 | 7kf | Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK) | 5tt7 | 82.84 |
| 23 | x9g | Crystal structure of an inhibitor-bound Syk | 4xg9 | 82.32 |
| 24 | gdh | CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE (SYK) IN COMPLEX WITH A 2-(PHENOXYMETHYL)PYRIDINE INHIBITOR | 6hm7 | 81.04 |
| 25 | 6zg | HUMAN SPLEEN TYROSINE KINASE KINASE DOMAIN IN COMPLEX WITH AZANAPHTHYRIDINE INHIBITOR | 5lma | 80.91 |
| 26 | 0k0 | Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor | 4dfl | 80.78 |
| 27 | 685 | Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK) | 3emg | 79.85 |
| 28 | 3yt | SYK Catalytic Domain Complexed with a Potent Pyrimidine Inhibitor | 4rx9 | 79.77 |
| 29 | 8ou | Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor | 5y5u | 79.67 |
| 30 | 6zf | HUMAN SPLEEN TYROSINE KINASE KINASE DOMAIN IN COMPLEX WITH AZANAPHTHYRIDINE INHIBITOR | 5lmb | 79.35 |
| 31 | 4mg | Crystal structure of tyrosine-protein kinase SYK with an inhibitor | 4rss | 78.57 |
| 32 | x7g | Crystal structure of an inhibitor-bound Syk | 4xg7 | 78.13 |
| 33 | x3g | Crystal structure of an inhibitor-bound Syk | 4xg3 | 77.24 |
| 34 | 50h | Crystal structure of SYK in complex with compound 1 | 5c26 | 77.15 |
| 35 | 8or | Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor | 5y5t | 75.3 |
| 36 | 1b4 | Crystal structure of spleen tyrosine kinase complexed with 2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide | 4i0r | 75.25 |
| 37 | 77v | Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine | 5t68 | 74.87 |
| 38 | 55u | SYK catalytic domain complexed with naphthyridine inhibitor | 5cxz | 74.83 |
| 39 | 0je | Crystal Structure of Spleen Tyrosine Kinase Syk Catalytic Domain with Pyrazolylbenzimidazole Inhibitor 416 | 3vf8 | 74.23 |
| 40 | 0vf | Crystal structure of spleen tyrosine kinase complexed with N-{(S)-1-[7-(3,4-Dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-pyrrolidin-3-yl}-terephthalamic acid | 4fyo | 74.1 |
| 41 | 50j | Crystal structure of SYK in complex with compound 2 | 5c27 | 73.92 |
| 42 | 057 | Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole | 3fqh | 72.58 |
| 43 | 3rt | SYK catalytic domain in complex with a potent triazolopyridine inhibitor | 4wnm | 72.56 |
| 44 | cg4 | Crystal structure of spleen tyrosine kinase (Syk) in complex with an imidazopyrazine inhibitor | 4pv0 | 72.11 |
| 45 | 0vg | Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2-Methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2-b]pyridazin-8-yl)-amine | 4fz6 | 72.04 |
| 46 | x4g | Crystal structure of an inhibitor-bound Syk | 4xg4 | 72.02 |
| 47 | 0ve | Crystal structure of spleen tyrosine kinase complexed with 3-(8-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-phenylamino}-imidazo[1,2-a]pyrazin-5-yl)-phenol | 4fyn | 69.81 |
| 48 | x5g | Crystal structure of an inhibitor-bound Syk | 5ghv | 69.13 |
| 49 | 585 | Crystal structure of spleen tyrosine kinase complexed with R406 | 3fqs | 66.02 |
| 50 | sti | Crystal structure of the syk tyrosine kinase domain with Gleevec | 1xbb | 60.69 |