| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | 2hw | Pim1 Complexed with a pyridylcarboxamide | 4n6z | 95 |
| 2 | q17 | Crystal structure of Pim1 in complex with 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol (resulting from displacement of SKF86002) | 4lm5 | 94.1 |
| 3 | 3t9 | Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution | 3t9i | 92.65 |
| 4 | myu | Crystal structure of Pim1 with Quercetagetin | 2o64 | 92.26 |
| 5 | xj1 | Protein kinase Pim-1 in complex with small molecule inibitor | 2xj1 | 91.43 |
| 6 | que | Crystal structure of Pim1 with Quercetin | 2o3p | 90.91 |
| 7 | q17 | Crystal structure of Pim1 kinase in complex with small molecule inhibitor | 3uix | 90.75 |
| 8 | 985 | Crystal structure of human Pim-1 in complex with DAPPA | 3f2a | 90.61 |
| 9 | c2j | Pim1 complexed with N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide | 6ayd | 90.56 |
| 10 | unm | The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors | 3r02 | 90.28 |
| 11 | 0f5 | Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design | 3vbq | 90.16 |
| 12 | 985 | Protein kinase Pim-1 in complex with small molecule inhibitor | 2xj2 | 89.85 |
| 13 | mvg | Human PIM1 kinase in complex with compound 12b | 6bsk | 89.61 |
| 14 | 7li | Novel and selective pan-PIM kinase inhibitor | 4dtk | 88.99 |
| 15 | li7 | Crystal Structure of Kinase Pim1 in complex with (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE | 1yxx | 88.95 |
| 16 | 6yn | Crystal structure of human Pim-1 kinase in complex with an imidazopyridazine inhibitor. | 5kzi | 88.92 |
| 17 | 5h7 | Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies | 5dwr | 88.62 |
| 18 | 2hx | Pim1 Complexed with a pyridylcarboxamide | 4n70 | 88.62 |
| 19 | 1ob | Structure of PIM-1 kinase bound to 5-(4-cyanobenzyl)-N-(4-fluorophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamide | 4k18 | 88.61 |
| 20 | 6cb | Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl-amide scaffold | 5iis | 88.44 |
| 21 | 5e6 | PIM1 in complex with Cpd36 ((1S,3S)-N1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)cyclohexane-1,3-diamine) | 5dia | 88.32 |
| 22 | 26k | Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors | 4mbi | 88.16 |
| 23 | kuv | PIM1 in complex with Cpd16 (5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide) | 6no9 | 88.16 |
| 24 | rtx | Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine derivatives | 4med | 88.05 |
| 25 | ugx | Crystal structure of PIM1 in complex with a Pyrrolo(1,2-a)Pyrazinone inhibitor | 4bzn | 88.04 |
| 26 | 3u6 | Crystal structure of human Pim-1 kinase in complex with a thiadiazolamine-indole inhibitor. | 4wt6 | 88.03 |
| 27 | que | Crystal structure of Pim1 in complex with the inhibitor Quercetin (resulting from displacement of SKF86002) | 4lmu | 87.84 |
| 28 | 26l | Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors | 4mbl | 87.59 |
| 29 | 3ng | Crystal structure of PIM1 kinase in complex with small-molecule inhibitor | 5o11 | 87.5 |
| 30 | jn5 | Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V | 3cy3 | 87.46 |
| 31 | 1oa | Structure of PIM-1 kinase bound to N-(4-fluorophenyl)-7-hydroxy-5-(piperidin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | 4k0y | 87.19 |
| 32 | 3yr | PIM1 kinase in complex with Compound 1s | 4xhk | 86.98 |
| 33 | vx2 | Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2 | 3bgq | 86.62 |
| 34 | 3ok | Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | 4rc4 | 86.48 |
| 35 | hy7 | Benzofuropyrimidinone Inhibitors of Pim-1 | 4alw | 86.19 |
| 36 | sk8 | Crystal Structure of Pim-1 in complex with the fluorescent compound SKF86002 | 4ll5 | 86.05 |
| 37 | hul | Crystal structure of proto-oncogene kinase Pim1 bound to hispidulin | 4xh6 | 85.67 |
| 38 | 3u1 | Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor. | 4wrs | 85.64 |
| 39 | 2hv | Pim1 Complexed with a phenylcarboxamide | 4n6y | 85.51 |
| 40 | 55e | Crystal structure of human Pim1 kinase complexed with 4-(4-hydroxy-3-methyl-phenyl)-6-phenylpyrimidin-2(1H)-one | 3dcv | 85.43 |
| 41 | 79o | Benzofuropyrimidinone Inhibitors of Pim-1 | 4alu | 84.87 |
| 42 | l20 | Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors | 5dgz | 84.4 |
| 43 | 676 | Crystal structure of PIM1 in complex with a Pyrrolo-Pyrazinone inhibitor | 4bzo | 84.37 |
| 44 | 8gx | Pim1 Kinase in complex with a benzofuranone inhibitor | 5vua | 83.71 |
| 45 | r9p | Benzofuropyrimidinone Inhibitors of Pim-1 | 4alv | 83.01 |
| 46 | 8gu | Pim1 Kinase in complex with a benzofuranone inhibitor | 5vub | 82.89 |
| 47 | 596 | Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one | 3umw | 82.65 |
| 48 | rtz | Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine | 4iaa | 81.94 |
| 49 | lxg | Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors | 3jxw | 81.47 |
| 50 | unq | The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors | 3r04 | 80.62 |
| 51 | 3o8 | Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | 4rc2 | 79.64 |
| 52 | 1oc | Structure of PIM-1 kinase bound to N-(5-(2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-((((3R,4R)-3-fluoropiperidin-4-yl)methyl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | 4k1b | 79.51 |
| 53 | 8et | Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and fragment like molekule N-quinolin-5-ylpyridine-3-carboxamide | 5mzl | 79.28 |
| 54 | 1n6 | Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one | 4jx7 | 78.83 |
| 55 | ocj | Human PIM1 bound to benzothiophene inhibitor 224 | 6pdi | 78.77 |
| 56 | adn | Structure of Pim-1 bound to adenosine | 1yi4 | 78.65 |
| 57 | 7au | Pim-1 kinase in complex with a 7-azaindole | 5tex | 78.65 |
| 58 | lyg | Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors | 3jy0 | 77.29 |
| 59 | o97 | Human PIM1 bound to benzothiophene inhibitor 213 | 6pcw | 75.34 |
| 60 | od4 | Human PIM1 bound to benzothiophene inhibitor 292 | 6pdn | 74.9 |
| 61 | 3oa | Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives | 4rc3 | 74.46 |
| 62 | 7aj | Pim-1 kinase in complex with a 7-azaindole | 5tel | 73 |
| 63 | od1 | Human PIM1 bound to benzothiophene inhibitor 354 | 6pdo | 70.8 |
| 64 | oby | Human PIM1 bound to benzothiophene inhibitor 379 | 6pdp | 70.73 |
| 65 | 9g5 | Crystal structure of PIM1 kinase in complex with small-molecule inhibitor | 5o13 | 70.35 |
| 66 | 6s3 | Pim-1 kinase in Complex with a Selective N-substituted 7-azaindole Inhibitor | 5kcx | 65.48 |