| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | 939 | CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 5-(2-AMINO- PYRIMIDIN-4-YL)-1H-PYRROLE INHIBITOR | 4a4l | 87.16 |
| 2 | 3ta | Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor | 3thb | 86.56 |
| 3 | 664 | CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 2-(2-AMINO- PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLOPYRIDIN-4-ONE INHIBITOR | 4a4o | 86.27 |
| 4 | 937 | Crystal structure of Polo-like kinase 1 in complex with NMS-P937 | 2yac | 85.89 |
| 5 | 071 | Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor | 3kb7 | 84.19 |
| 6 | 626 | Structure of the Catalytic Domain of Human Polo-like Kinase 1 | 2owb | 81.23 |
| 7 | r78 | Structure of PLK1 in complex with BI2536 | 2rku | 73.23 |
| 8 | 79d | Crystal structure of PLK1 in complex with a novel 5,6-dihydroimidazolo[1,5-f]pteridine inhibitor. | 5ta6 | 72.11 |
| 9 | 79c | Crystal structure of PLK1 in complex with a novel 5,6-dihydroimidazolo[1,5-f]pteridine inhibitor | 5ta8 | 70.83 |
| 10 | 1j3 | Crystal structure of PLK1 in complex with a pyrimidodiazepinone inhibitor | 4j52 | 70.75 |
| 11 | 1j4 | Crystal structure of PLK1 in complex with TAK-960 | 4j53 | 70.65 |